| Title : Activation Mechanisms for Pseudomonas species Lipase by Cardiovascular Drugs in Vitro - Lin_2007_J.Chin.Chem.Soc_54_1601 |
| Author(s) : Lin MC , Lai GW , Lin CS , Lin G |
| Ref : Journal of the Chinese Chemical Society , 54 :1601 , 2007 |
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Abstract :
The goal of this work was to determine the reaction mechanism for Pseudomonas species lipase activation by cardiovascular drugs such as lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride based on the results from enzyme kinetics. These drugs are the essential activators of Pseudomonas species lipase in the presence of triton-X 100 or taurochloate in vitro. Moreover, QSAR studies show that the pKA values are correlated with the molecular weights of these drugs. |
| PubMedSearch : Lin_2007_J.Chin.Chem.Soc_54_1601 |
| PubMedID: |
| Gene_locus related to this paper: pseae-llipa |
| Gene_locus | pseae-llipa |
Lin MC, Lai GW, Lin CS, Lin G (2007)
Activation Mechanisms for Pseudomonas species Lipase by Cardiovascular Drugs in Vitro
Journal of the Chinese Chemical Society
54 :1601
Lin MC, Lai GW, Lin CS, Lin G (2007)
Journal of the Chinese Chemical Society
54 :1601