| Title : Vibralactone: a lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans - Liu_2006_Org.Lett_8_5749 |
| Author(s) : Liu DZ , Wang F , Liao TG , Tang JG , Steglich W , Zhu HJ , Liu JK |
| Ref : Org Lett , 8 :5749 , 2006 |
|
Abstract :
The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 microg/mL. [structure: see text] |
| PubMedSearch : Liu_2006_Org.Lett_8_5749 |
| PubMedID: 17134263 |
| Gene_locus related to this paper: human-PNLIP |
| Inhibitor | Vibralactone |
| Gene_locus | human-PNLIP |
Liu DZ, Wang F, Liao TG, Tang JG, Steglich W, Zhu HJ, Liu JK (2006)
Vibralactone: a lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans
Org Lett
8 :5749
Liu DZ, Wang F, Liao TG, Tang JG, Steglich W, Zhu HJ, Liu JK (2006)
Org Lett
8 :5749