Zhu HJ

References (44)

Title : Regulation of human hydrolases and its implications in pharmacokinetics and pharmacodynamics - Jung_2024_Drug.Metab.Dispos__
Author(s) : Jung SM , Zhu HJ
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2024
Abstract :
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Title : Regulation of carboxylesterases and its impact on pharmacokinetics and pharmacodynamics: an up-to-date review - Liu_2024_Expert.Opin.Drug.Metab.Toxicol__1
Author(s) : Liu Y , Li J , Zhu HJ
Ref : Expert Opin Drug Metab Toxicol , :1 , 2024
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PubMedID: 38706437

Title : Targeted Absolute Protein Quantification Using SILAC Internal Standard and Full-Length Protein Calibrators (TAQSI) - Wang_2023_Methods.Mol.Biol_2603_269
Author(s) : Wang X , Shi J , Zhu HJ
Ref : Methods Mol Biol , 2603 :269 , 2023
Abstract :
PubMedSearch : Wang_2023_Methods.Mol.Biol_2603_269
PubMedID: 36370287

Title : Cell-Dependent Activation of ProTide Prodrugs and Its Implications in Antiviral Studies - Liu_2023_ACS.Pharmacol.Transl.Sci_6_1340
Author(s) : Liu Y , Sun S , Li J , Wang W , Zhu HJ
Ref : ACS Pharmacol Transl Sci , 6 :1340 , 2023
Abstract :
PubMedSearch : Liu_2023_ACS.Pharmacol.Transl.Sci_6_1340
PubMedID: 37854623

Title : Physiologically-based pharmacokinetic modeling to predict methylphenidate exposure affected by interplay among carboxylesterase 1 pharmacogenetics, drug-drug interactions, and sex - Xiao_2022_J.Pharm.Sci__
Author(s) : Xiao J , Shi J , Thompson BR , Smith DE , Zhang T , Zhu HJ
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PubMedSearch : Xiao_2022_J.Pharm.Sci__
PubMedID: 35526575

Title : Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms - Her_2022_Proteomics__e2200176
Author(s) : Her L , Shi J , Wang X , He B , Smith L , Jiang H , Zhu HJ
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PubMedSearch : Her_2022_Proteomics__e2200176
PubMedID: 36413357
Gene_locus related to this paper: human-CES1

Title : Activation of Tenofovir Alafenamide and Sofosbuvir in the Human Lung and Its Implications in the Development of Nucleoside\/Nucleotide Prodrugs for Treating SARS-CoV-2 Pulmonary Infection - Li_2021_Pharmaceutics_13_
Author(s) : Li J , Liu S , Shi J , Zhu HJ
Ref : Pharmaceutics , 13 : , 2021
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PubMedSearch : Li_2021_Pharmaceutics_13_
PubMedID: 34683949
Gene_locus related to this paper: human-CTSA

Title : Transcriptional regulation of carboxylesterase 1 (CES1) in human liver: role of the nuclear receptor NR1H3 (LXRalpha) and its splice isoforms - Collins_2021_Drug.Metab.Dispos__
Author(s) : Collins JM , Lu R , Wang X , Zhu HJ , Wang D
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2021
Abstract :
PubMedSearch : Collins_2021_Drug.Metab.Dispos__
PubMedID: 34697082
Gene_locus related to this paper: human-CES1

Title : Contributions of Cathepsin A and Carboxylesterase 1 to the hydrolysis of Tenofovir Alafenamide in the Human Liver, and the Effect of CES1 Genetic Variation on Tenofovir Alafenamide Hydrolysis - Li_2021_Drug.Metab.Dispos__
Author(s) : Li J , Shi J , Xiao J , Tran L , Wang X , Zhu HJ
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2021
Abstract :
PubMedSearch : Li_2021_Drug.Metab.Dispos__
PubMedID: 34933885
Gene_locus related to this paper: human-CES1 , human-CTSA

Title : Plasma carboxylesterase 1 predicts methylphenidate exposure: a proof-of-concept study using plasma protein biomarker for hepatic drug metabolism - Shi_2021_Clin.Pharmacol.Ther__
Author(s) : Shi J , Xiao J , Wang X , Jung SM , Bleske BE , Markowitz JS , Patrick KS , Zhu HJ
Ref : Clinical Pharmacology & Therapeutics , : , 2021
Abstract :
PubMedSearch : Shi_2021_Clin.Pharmacol.Ther__
PubMedID: 34743324

Title : Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects - Her_2021_Br.J.Clin.Pharmacol__
Author(s) : Her LH , Wang X , Shi J , Choi HJ , Jung SM , Smith LS , Wu AH , Bleske BE , Zhu HJ
Ref : British Journal of Clinical Pharmacology , : , 2021
Abstract :
PubMedSearch : Her_2021_Br.J.Clin.Pharmacol__
PubMedID: 33963573

Title : Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers - Wang_2021_Clin.Transl.Sci__
Author(s) : Wang X , Her L , Xiao J , Shi J , Wu AH , Bleske BE , Zhu HJ
Ref : Clin Transl Sci , : , 2021
Abstract :
PubMedSearch : Wang_2021_Clin.Transl.Sci__
PubMedID: 33660934

Title : Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators - Her_2020_Drug.Metab.Dispos_48_230
Author(s) : Her L , Zhu HJ
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 48 :230 , 2020
Abstract :
PubMedSearch : Her_2020_Drug.Metab.Dispos_48_230
PubMedID: 31871135
Gene_locus related to this paper: human-CES1

Title : Chemoproteomic Identification of Serine Hydrolase RBBP9 as a Valacyclovir-Activating Enzyme - Shenoy_2020_Mol.Pharm_17_1706
Author(s) : Shenoy VM , Thompson BR , Shi J , Zhu HJ , Smith DE , Amidon GL
Ref : Mol Pharm , 17 :1706 , 2020
Abstract :
PubMedSearch : Shenoy_2020_Mol.Pharm_17_1706
PubMedID: 32196348
Gene_locus related to this paper: human-RBBP9

Title : FRACPRED-2D-PRM: A fraction prediction algorithm-assisted two-dimensional liquid chromatography-based parallel reaction monitoring-mass spectrometry approach for measuring low-abundance proteins in human plasma - Shi_2020_Proteomics__e2000175
Author(s) : Shi J , Xiao J , Li J , Wang X , Her L , Sorensen MJ , Zhu HJ
Ref : Proteomics , :e2000175 , 2020
Abstract :
PubMedSearch : Shi_2020_Proteomics__e2000175
PubMedID: 33085175

Title : Label-free absolute protein quantification with data-independent acquisition - He_2019_J.Proteomics_200_51
Author(s) : He B , Shi J , Wang X , Jiang H , Zhu HJ
Ref : J Proteomics , 200 :51 , 2019
Abstract :
PubMedSearch : He_2019_J.Proteomics_200_51
PubMedID: 30880166

Title : Functional study of Carboxylesterase 1 protein isoforms - Wang_2018_Proteomics__e1800288
Author(s) : Wang X , Shi J , Zhu HJ
Ref : Proteomics , :e1800288 , 2018
Abstract :
PubMedSearch : Wang_2018_Proteomics__e1800288
PubMedID: 30520264

Title : Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice - Hu_2018_Biochem.Pharmacol_156_147
Author(s) : Hu Y , Epling D , Shi J , Song F , Tsume Y , Zhu HJ , Amidon GL , Smith DE
Ref : Biochemical Pharmacology , 156 :147 , 2018
Abstract :
PubMedSearch : Hu_2018_Biochem.Pharmacol_156_147
PubMedID: 30121252
Gene_locus related to this paper: human-BPHL

Title : Ethanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers - Zhu_2017_J.Clin.Psychopharmacol_37_419
Author(s) : Zhu HJ , Patrick KS , Straughn AB , Reeves OT, 3rd , Bernstein H , Shi J , Johnson HJ , Knight JM , Smith AT , Malcolm RJ , Markowitz JS
Ref : J Clin Psychopharmacol , 37 :419 , 2017
Abstract :
PubMedSearch : Zhu_2017_J.Clin.Psychopharmacol_37_419
PubMedID: 28590363

Title : A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms - Wang_2017_Drug.Metab.Dispos_45_1149
Author(s) : Wang X , Rida N , Shi J , Wu AH , Bleske BE , Zhu HJ
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 45 :1149 , 2017
Abstract :
PubMedSearch : Wang_2017_Drug.Metab.Dispos_45_1149
PubMedID: 28838926
Gene_locus related to this paper: human-CES1

Title : Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender - Shi_2016_Biochem.Pharmacol_119_76
Author(s) : Shi J , Wang X , Nguyen JH , Bleske BE , Liang Y , Liu L , Zhu HJ
Ref : Biochemical Pharmacology , 119 :76 , 2016
Abstract :
PubMedSearch : Shi_2016_Biochem.Pharmacol_119_76
PubMedID: 27614009
Gene_locus related to this paper: human-CES1

Title : Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms - Shi_2016_Basic.Clin.Pharmacol.Toxicol_119_555
Author(s) : Shi J , Wang X , Eyler RF , Liang Y , Liu L , Mueller BA , Zhu HJ
Ref : Basic Clin Pharmacol Toxicol , 119 :555 , 2016
Abstract :
PubMedSearch : Shi_2016_Basic.Clin.Pharmacol.Toxicol_119_555
PubMedID: 27228223
Gene_locus related to this paper: human-CES1

Title : CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors - Wang_2016_Pharmacogenomics.J_16_220
Author(s) : Wang X , Wang G , Shi J , Aa JY , Comas R , Liang Y , Zhu HJ
Ref : Pharmacogenomics J , 16 :220 , 2016
Abstract :
PubMedSearch : Wang_2016_Pharmacogenomics.J_16_220
PubMedID: 26076923
Gene_locus related to this paper: human-CES1

Title : Targeted absolute quantitative proteomics with SILAC internal standards and unlabeled full-length protein calibrators (TAQSI) - Wang_2016_Rapid.Commun.Mass.Spectrom_30_553
Author(s) : Wang X , Liang Y , Liu L , Shi J , Zhu HJ
Ref : Rapid Commun Mass Spectrom , 30 :553 , 2016
Abstract :
PubMedSearch : Wang_2016_Rapid.Commun.Mass.Spectrom_30_553
PubMedID: 26842578

Title : CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril - Zhu_2016_Eur.J.Clin.Pharmacol_72_681
Author(s) : Zhu HJ , Langaee TY , Gong Y , Wang X , Pepine CJ , Cooper-DeHoff RM , Johnson JA , Markowitz JS
Ref : European Journal of Clinical Pharmacology , 72 :681 , 2016
Abstract :
PubMedSearch : Zhu_2016_Eur.J.Clin.Pharmacol_72_681
PubMedID: 26915813
Gene_locus related to this paper: human-CES1

Title : Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus - Sanford_2016_Pharmacogenet.Genomics_26_197
Author(s) : Sanford JC , Wang X , Shi J , Barrie ES , Wang D , Zhu HJ , Sadee W
Ref : Pharmacogenet Genomics , 26 :197 , 2016
Abstract :
PubMedSearch : Sanford_2016_Pharmacogenet.Genomics_26_197
PubMedID: 26871237
Gene_locus related to this paper: human-CES1

Title : Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation - Shi_2016_Drug.Metab.Dispos_44_554
Author(s) : Shi J , Wang X , Nguyen J , Wu AH , Bleske BE , Zhu HJ
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :554 , 2016
Abstract :
PubMedSearch : Shi_2016_Drug.Metab.Dispos_44_554
PubMedID: 26817948
Gene_locus related to this paper: human-CES1

Title : Carboxylesterase 1-Mediated Drug-Drug Interactions between Clopidogrel and Simvastatin - Wang_2015_Biol.Pharm.Bull_38_292
Author(s) : Wang X , Zhu HJ , Markowitz JS
Ref : Biol Pharm Bull , 38 :292 , 2015
Abstract :
PubMedSearch : Wang_2015_Biol.Pharm.Bull_38_292
PubMedID: 25747989

Title : Clopidogrel Bioactivation and Risk of Bleeding in Patients Cotreated With Angiotensin-Converting Enzyme Inhibitors After Myocardial Infarction: A Proof-of-Concept Study - Kristensen_2014_Clin.Pharmacol.Ther_96_713
Author(s) : Kristensen KE , Zhu HJ , Wang X , Gislason GH , Torp-Pedersen C , Rasmussen HB , Markowitz JS , Hansen PR
Ref : Clinical Pharmacology & Therapeutics , 96 :713 , 2014
Abstract :
PubMedSearch : Kristensen_2014_Clin.Pharmacol.Ther_96_713
PubMedID: 25222620

Title : Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction liability - Markowitz_2013_J.Child.Adolesc.Psychopharmacol_23_648
Author(s) : Markowitz JS , Zhu HJ , Patrick KS
Ref : J Child Adolesc Psychopharmacol , 23 :648 , 2013
Abstract :
PubMedSearch : Markowitz_2013_J.Child.Adolesc.Psychopharmacol_23_648
PubMedID: 24261661

Title : Carboxylesterase 1 (CES1) genetic polymorphisms and oseltamivir activation -
Author(s) : Zhu HJ , Markowitz JS
Ref : European Journal of Clinical Pharmacology , 69 :733 , 2013
PubMedID: 22847618

Title : Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation - Zhu_2013_J.Pharmacol.Exp.Ther_344_665
Author(s) : Zhu HJ , Wang X , Gawronski BE , Brinda BJ , Angiolillo DJ , Markowitz JS
Ref : Journal of Pharmacology & Experimental Therapeutics , 344 :665 , 2013
Abstract :
PubMedSearch : Zhu_2013_J.Pharmacol.Exp.Ther_344_665
PubMedID: 23275066
Gene_locus related to this paper: human-CES1

Title : A discriminative analytical method for detection of CES1A1 and CES1A2\/CES1A3 genetic variants - Zhu_2012_Pharmacogenet.Genomics_22_215
Author(s) : Zhu HJ , Brinda B , Froehlich TE , Markowitz JS
Ref : Pharmacogenet Genomics , 22 :215 , 2012
Abstract :
PubMedSearch : Zhu_2012_Pharmacogenet.Genomics_22_215
PubMedID: 22237548
Gene_locus related to this paper: human-CES1

Title : Prediction and in vitro evaluation of selected protease inhibitor antiviral drugs as inhibitors of carboxylesterase 1: a potential source of drug-drug interactions - Rhoades_2012_Pharm.Res_29_972
Author(s) : Rhoades JA , Peterson YK , Zhu HJ , Appel DI , Peloquin CA , Markowitz JS
Ref : Pharm Res , 29 :972 , 2012
Abstract :
PubMedSearch : Rhoades_2012_Pharm.Res_29_972
PubMedID: 22161308

Title : Enantiospecific determination of dl-methylphenidate and dl-ethylphenidate in plasma by liquid chromatography-tandem mass spectrometry: Application to human ethanol interactions - Zhu_2011_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_879_783
Author(s) : Zhu HJ , Patrick KS , Markowitz JS
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 879 :783 , 2011
Abstract :
PubMedSearch : Zhu_2011_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_879_783
PubMedID: 21402502

Title : Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: potential sources of metabolic drug interactions - Zhu_2010_Toxicology_270_59
Author(s) : Zhu HJ , Appel DI , Peterson YK , Wang Z , Markowitz JS
Ref : Toxicology , 270 :59 , 2010
Abstract :
PubMedSearch : Zhu_2010_Toxicology_270_59
PubMedID: 20097249

Title : Age- and sex-related expression and activity of carboxylesterase 1 and 2 in mouse and human liver - Zhu_2009_Drug.Metab.Dispos_37_1819
Author(s) : Zhu HJ , Appel DI , Jiang Y , Markowitz JS
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 37 :1819 , 2009
Abstract :
PubMedSearch : Zhu_2009_Drug.Metab.Dispos_37_1819
PubMedID: 19487248

Title : Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants - Zhu_2009_Drug.Metab.Dispos_37_264
Author(s) : Zhu HJ , Markowitz JS
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 37 :264 , 2009
Abstract :
PubMedSearch : Zhu_2009_Drug.Metab.Dispos_37_264
PubMedID: 19022936
Gene_locus related to this paper: human-CES1

Title : Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril - Zhu_2009_Biochem.Pharmacol_77_1266
Author(s) : Zhu HJ , Appel DI , Johnson JA , Chavin KD , Markowitz JS
Ref : Biochemical Pharmacology , 77 :1266 , 2009
Abstract :
PubMedSearch : Zhu_2009_Biochem.Pharmacol_77_1266
PubMedID: 19185566
Gene_locus related to this paper: human-CES1

Title : Enantiospecific gas chromatographic-mass spectrometric analysis of urinary methylphenidate: implications for phenotyping - LeVasseur_2008_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_862_140
Author(s) : LeVasseur NL , Zhu HJ , Markowitz JS , DeVane CL , Patrick KS
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 862 :140 , 2008
Abstract :
PubMedSearch : LeVasseur_2008_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_862_140
PubMedID: 18155648

Title : Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population - Tang_2008_J.Lipid.Res_49_369
Author(s) : Tang NP , Wang LS , Yang L , Zhou B , Gu HJ , Sun QM , Cong RH , Zhu HJ , Wang B
Ref : J Lipid Res , 49 :369 , 2008
Abstract :
PubMedSearch : Tang_2008_J.Lipid.Res_49_369
PubMedID: 17986713
Gene_locus related to this paper: human-LIPG

Title : Derivatives of vibralactone from cultures of the basidiomycete Boreostereum vibrans - Jiang_2008_Chem.Pharm.Bull.(Tokyo)_56_1286
Author(s) : Jiang MY , Wang F , Yang XL , Fang LZ , Dong ZJ , Zhu HJ , Liu JK
Ref : Chem Pharm Bull (Tokyo) , 56 :1286 , 2008
Abstract :
PubMedSearch : Jiang_2008_Chem.Pharm.Bull.(Tokyo)_56_1286
PubMedID: 18758102

Title : Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis - Zhu_2008_Am.J.Hum.Genet_82_1241
Author(s) : Zhu HJ , Patrick KS , Yuan HJ , Wang JS , Donovan JL , DeVane CL , Malcolm R , Johnson JA , Youngblood GL , Sweet DH , Langaee TY , Markowitz JS
Ref : American Journal of Human Genetics , 82 :1241 , 2008
Abstract :
PubMedSearch : Zhu_2008_Am.J.Hum.Genet_82_1241
PubMedID: 18485328
Gene_locus related to this paper: human-CES1

Title : Vibralactone: a lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans - Liu_2006_Org.Lett_8_5749
Author(s) : Liu DZ , Wang F , Liao TG , Tang JG , Steglich W , Zhu HJ , Liu JK
Ref : Org Lett , 8 :5749 , 2006
Abstract :
PubMedSearch : Liu_2006_Org.Lett_8_5749
PubMedID: 17134263