| Title : Deciphering the venomic transcriptome of killer-wasp Vespa velutina - Liu_2015_Sci.Rep_5_9454 |
| Author(s) : Liu Z , Chen S , Zhou Y , Xie C , Zhu B , Zhu H , Liu S , Wang W , Chen H , Ji Y |
| Ref : Sci Rep , 5 :9454 , 2015 |
| Abstract : Wasp stings have been arising to be a severe public health problem in China in recent years. However, molecular information about lethal or toxic factors in wasp venom is extremely lacking. In this study, we used two pyrosequencing platforms to analyze the transcriptome of Vespa velutina, the most common wasp species native in China. Besides the substantial amount of transcripts encoding for allergens usually regarded as the major lethal factor of wasp sting, a greater abundance of hemostasis-impairing toxins and neurotoxins in the venom of V. velutina were identified, implying that toxic reactions and allergic effects are envenoming strategy for the dangerous outcomes. The pattern of differentially expressed genes before and after venom extraction clearly indicates that the manifestation of V. velutina stings depends on subtle regulations in the metabolic pathway required for toxin recruitment. This comparative analysis offers timely clues for developing clinical treatments for wasp envenoming in China and around the world. |
| ESTHER : Liu_2015_Sci.Rep_5_9454 |
| PubMedSearch : Liu_2015_Sci.Rep_5_9454 |
| PubMedID: 25896434 |
| Gene_locus related to this paper: vesve-pa1 |
| Gene_locus related to this paper: vesve-pa1 |
Liu Z, Chen S, Zhou Y, Xie C, Zhu B, Zhu H, Liu S, Wang W, Chen H, Ji Y (2015)
Deciphering the venomic transcriptome of killer-wasp Vespa velutina
Sci Rep
5 :9454
Liu Z, Chen S, Zhou Y, Xie C, Zhu B, Zhu H, Liu S, Wang W, Chen H, Ji Y (2015)
Sci Rep
5 :9454