| Title : Detection of target site mutations in the acetylcholinesterase and voltage-gated sodium channel in field populations of Culex quinquefasciatus and Cx. tritaeniorhynchus from southern Sichuan region of China - Liu_2023_J.Am.Mosq.Control.Assoc__ |
| Author(s) : Liu J , Wang Y , Liu P , Yu X , Tan AI , Zeng J , Li L , Qiu X |
| Ref : J Am Mosq Control Assoc , : , 2023 |
| Abstract : Culex quinquefasciatus and Cx. tritaeniorhynchus are 2 dominant disease vectors in Neijiang City, Sichuan Province, China. Although there is evidence of confirmed resistance against insecticides in mosquito vectors, nothing is known about the existing insecticide resistance-conferring mutations in Cx. quinquefasciatus and Cx. tritaeniorhynchu in this region so far. In this study, the G119S mutation in the acetylcholinesterase (AChE) was detected in Cx. quinquefasciatus at a very low frequency (0.9%) with no resistant homozygotes being observed. Two resistance mutations in the voltage-gated sodium channel (VGSC) (L1014F and L1014S) were found in Cx. quinquefasciatus with frequencies of 88.7% and 8.3%, respectively. By contrast, the AChE F455W mutation was found to be fixed (with a frequency of 100%) in 3 of the 5 studied populations, with an overall frequency being 98.1%. In addition, 1 resistance-conferring VGSC mutation (L1014F) was detected with an overall frequency of 15.2% in Cx. tritaeniorhynchus. These results indicate that the well-recognized insecticide resistance-conferring mutations in both AChE and VGSC are present in the 2 Culex species in Neijiang. The contrasting patterns in the frequency of resistance alleles indicate that species-customized strategies of insecticide resistance management should be considered for the 2 species. |
| ESTHER : Liu_2023_J.Am.Mosq.Control.Assoc__ |
| PubMedSearch : Liu_2023_J.Am.Mosq.Control.Assoc__ |
| PubMedID: 36752737 |
Liu J, Wang Y, Liu P, Yu X, Tan AI, Zeng J, Li L, Qiu X (2023)
Detection of target site mutations in the acetylcholinesterase and voltage-gated sodium channel in field populations of Culex quinquefasciatus and Cx. tritaeniorhynchus from southern Sichuan region of China
J Am Mosq Control Assoc
:
Liu J, Wang Y, Liu P, Yu X, Tan AI, Zeng J, Li L, Qiu X (2023)
J Am Mosq Control Assoc
: