Title : The Relationship Between Hepatic Lipase Gene Variant and Advanced Age-Related Macular Degeneration: A Meta-analysis - Lou_2014_JAMA.Ophthalmol_132_1226 |
Author(s) : Lou LX , Hu KM , Jin K , Zhang SZ , Ye J |
Ref : JAMA Ophthalmol , 132 :1226 , 2014 |
Abstract :
IMPORTANCE: To date, no consistency exists across studies that have evaluated the relationship between hepatic lipase gene (LIPC) rs10468017 variant and advanced age-related macular degeneration (AMD). OBJECTIVE: To summarize all relevant evidence for a relationship between LIPC variant and advanced AMD. DATA SOURCES: The PubMed and Embase databases were searched for studies potentially eligible in any language published up to September 15, 2013. STUDY SELECTION: Case-control studies of 2 or more comparison groups that included patients with advanced AMD (choroidal neovascularization or geographic atrophy). DATA EXTRACTION AND SYNTHESIS: Allele frequencies and genotype distributions of rs10468017 variant. MAIN OUTCOMES AND MEASURES: Summary odds ratios (ORs) and 95% CIs were estimated under different genetic models using meta-analytic methods. A stratified analysis by advanced AMD subtypes and race/ethnicity was performed, as well as a sensitivity analysis. |
PubMedSearch : Lou_2014_JAMA.Ophthalmol_132_1226 |
PubMedID: 25010633 |
Lou LX, Hu KM, Jin K, Zhang SZ, Ye J (2014)
The Relationship Between Hepatic Lipase Gene Variant and Advanced Age-Related Macular Degeneration: A Meta-analysis
JAMA Ophthalmol
132 :1226
Lou LX, Hu KM, Jin K, Zhang SZ, Ye J (2014)
JAMA Ophthalmol
132 :1226