Lou_2014_JAMA.Ophthalmol_132_1226

Reference

Title : The Relationship Between Hepatic Lipase Gene Variant and Advanced Age-Related Macular Degeneration: A Meta-analysis - Lou_2014_JAMA.Ophthalmol_132_1226
Author(s) : Lou LX , Hu KM , Jin K , Zhang SZ , Ye J
Ref : JAMA Ophthalmol , 132 :1226 , 2014
Abstract :

IMPORTANCE: To date, no consistency exists across studies that have evaluated the relationship between hepatic lipase gene (LIPC) rs10468017 variant and advanced age-related macular degeneration (AMD). OBJECTIVE: To summarize all relevant evidence for a relationship between LIPC variant and advanced AMD. DATA SOURCES: The PubMed and Embase databases were searched for studies potentially eligible in any language published up to September 15, 2013. STUDY SELECTION: Case-control studies of 2 or more comparison groups that included patients with advanced AMD (choroidal neovascularization or geographic atrophy). DATA EXTRACTION AND SYNTHESIS: Allele frequencies and genotype distributions of rs10468017 variant. MAIN OUTCOMES AND MEASURES: Summary odds ratios (ORs) and 95% CIs were estimated under different genetic models using meta-analytic methods. A stratified analysis by advanced AMD subtypes and race/ethnicity was performed, as well as a sensitivity analysis.
RESULTS: Data from 10 case-control studies were included in the meta-analysis. The rs10468017 variant (C-->T) showed significant summary ORs of 0.81 (95% CI, 0.75-0.88), 0.83 (95% CI, 0.70-0.98), and 0.60 (95% CI, 0.44-0.81) under the allelic (T vs C), heterozygous (TC vs CC), and homozygous (TT vs CC) models, respectively. Carrying at least 1 copy of the T allele decreased the risk of choroidal neovascularization and geographic atrophy by 20% (OR, 0.80; 95% CI, 0.74-0.87) and 29% (OR, 0.71; 95% CI, 0.59-0.86), respectively. The pooled OR for white race/ethnicity under an allelic model was 0.80 (95% CI, 0.74-0.87). The sensitivity analysis indicated the robustness of our findings, and no evidence of publication bias was observed in our meta-analysis. CONCLUSIONS AND RELEVANCE: Our meta-analysis indicates that LIPC rs10468017 variant is associated with a reduced risk of advanced AMD. This finding may lead to insights regarding the pathogenesis, prevention, and treatment of AMD.

PubMedSearch : Lou_2014_JAMA.Ophthalmol_132_1226
PubMedID: 25010633

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Citations formats

Lou LX, Hu KM, Jin K, Zhang SZ, Ye J (2014)
The Relationship Between Hepatic Lipase Gene Variant and Advanced Age-Related Macular Degeneration: A Meta-analysis
JAMA Ophthalmol 132 :1226

Lou LX, Hu KM, Jin K, Zhang SZ, Ye J (2014)
JAMA Ophthalmol 132 :1226