| Title : In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase - Lowe_2004_Bioorg.Med.Chem.Lett_14_3155 |
| Author(s) : Lowe DB , Magnuson S , Qi N , Campbell AM , Cook J , Hong Z , Wang M , Rodriguez M , Achebe F , Kluender H , Wong WC , Bullock WH , Salhanick AI , Witman-Jones T , Bowling ME , Keiper C , Clairmont KB |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :3155 , 2004 |
|
Abstract :
A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes. |
| PubMedSearch : Lowe_2004_Bioorg.Med.Chem.Lett_14_3155 |
| PubMedID: 15149665 |
| Gene_locus related to this paper: human-LIPE |
| Inhibitor | BAY-59-9435 CHEMBL106375 |
| Gene_locus | human-LIPE |
Lowe DB, Magnuson S, Qi N, Campbell AM, Cook J, Hong Z, Wang M, Rodriguez M, Achebe F, Kluender H, Wong WC, Bullock WH, Salhanick AI, Witman-Jones T, Bowling ME, Keiper C, Clairmont KB (2004)
In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase
Bioorganic & Medicinal Chemistry Lett
14 :3155
Lowe DB, Magnuson S, Qi N, Campbell AM, Cook J, Hong Z, Wang M, Rodriguez M, Achebe F, Kluender H, Wong WC, Bullock WH, Salhanick AI, Witman-Jones T, Bowling ME, Keiper C, Clairmont KB (2004)
Bioorganic & Medicinal Chemistry Lett
14 :3155