Lummis_1988_Neurosci.Lett_87_145

Reference

Title : The cross-linking reagent dimethyl suberimate modifies the target size of an insect nervous system nicotinic acetylcholine receptor - Lummis_1988_Neurosci.Lett_87_145
Author(s) : Lummis SC , Ellory JC , Sattelle DB
Ref : Neuroscience Letters , 87 :145 , 1988
Abstract :

Radiation inactivation and simple target theory were employed to determine the molecular weight of an insect CNS alpha-bungarotoxin binding component in the presence and absence of a cross-linking reagent, dimethyl suberimate. In the presence of the cross-linker, the number of binding sites decreased, and the apparent molecular weight (236,000) was approximately double the control value (112,000). This, together with sedimentation data, suggests that the lower value represents only a portion of the insect nicotinic receptor molecule. A model is presented to account for the increase in target size and reduction in the number of alpha-[3H]bungarotoxin binding sites in the presence of dimethyl suberimate.

PubMedSearch : Lummis_1988_Neurosci.Lett_87_145
PubMedID: 3380333

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Citations formats

Lummis SC, Ellory JC, Sattelle DB (1988)
The cross-linking reagent dimethyl suberimate modifies the target size of an insect nervous system nicotinic acetylcholine receptor
Neuroscience Letters 87 :145

Lummis SC, Ellory JC, Sattelle DB (1988)
Neuroscience Letters 87 :145