Ma_2012_Zhonghua.Nei.Ke.Za.Zhi_51_618

OBJECTIVE To verify and assess diagnostic value of noninvasive diagnostic model of liver fibrosis in primary biliary cirrhosis PBC based on conventional laboratory markers METHODS Seventy-three patients with PBC diagnosed by liver biopsy between January 2003 and June 2011 in Beijing Friendship Hospital Capital Medical University were recruited in this study Correlation analysis and logistic regression analysis between the conventional laboratory markers and histology stages were assessed A liver fibrosis diagnostic model was established based upon aforementioned biomarkers and verified by its sensitivity and specificity for predicting the liver fibrosis RESULTS The predictive model H index consisting of five conventional laboratory markers i.e platelet count serum cholinesterase albumin HDL-C and prothrombin time activity could predict advanced fibrosis stages III-IV with an AUC(ROC of 0.861 The sensitivity of predicting the absence of advanced fibrosis using H index 2.20 was 96.6 and the specificity of predicting the presence of advanced fibrosis using H index 0.41 was 93.2 CONCLUSION The established noninvasive diagnostic model consisting of five laboratory markers could accurately distinguish pathological changes of early stage PBC stages I-II from advanced stage PBC stages III-IV).