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Macan_2015_Pharmacol.Rep_67_907

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Title : Effects of simvastatin on malondialdehyde level and esterase activity in plasma and tissue of normolipidemic rats - Macan_2015_Pharmacol.Rep_67_907
Author(s) : Macan M , Vuksic A , Zunec S , Konjevoda P , Lovric J , Kelava M , Stambuk N , Vrkic N , Bradamante V
Ref : Pharmacol Rep , 67 :907 , 2015
Abstract :

BACKGROUND: We investigated the possible non-lipid effects of simvastatin (SIMV) on paraoxonase 1 (PON1) and butyrylcholinesterase (BuChE) activity, as well as on malondialdehyde (MDA) levels in normolipidemic rats.
METHODS: Two experimental groups of Wistar rats (10mg/kg/day of SIMV) and two control groups (saline) underwent a 21-day treatment period (TP). On the 22nd day one experimental and one control group of rats were sacrificed. Remaining groups of animals were sacrificied on the 32nd day of the study (10-day after-treatment period (AT)). Blood samples and slices of liver, heart, kidney, and brain tissue were obtained for the measurement of PON1 and BuChE activity and levels of MDA. Data were analyzed by means of t-test for independent samples. p valuesRESULTS: SIMV caused a significant decrease of serum and liver PON1 activity (18-24%, p

PubMedSearch : Macan_2015_Pharmacol.Rep_67_907
PubMedID: 26398384

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Macan M, Vuksic A, Zunec S, Konjevoda P, Lovric J, Kelava M, Stambuk N, Vrkic N, Bradamante V (2015)
Effects of simvastatin on malondialdehyde level and esterase activity in plasma and tissue of normolipidemic rats
Pharmacol Rep 67 :907

Macan M, Vuksic A, Zunec S, Konjevoda P, Lovric J, Kelava M, Stambuk N, Vrkic N, Bradamante V (2015)
Pharmacol Rep 67 :907