Title : Lipoprotein-associated phospholipase A2 activity predicts cardiovascular events in high risk coronary artery disease patients - Maiolino_2012_PLoS.One_7_e48171 |
Author(s) : Maiolino G , Pedon L , Cesari M , Frigo AC , Wolfert RL , Barisa M , Pagliani L , Rossitto G , Seccia TM , Zanchetta M , Rossi GP |
Ref : PLoS ONE , 7 :e48171 , 2012 |
Abstract :
OBJECTIVE: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is deemed to play a role in atherosclerosis and plaque destabilization as demonstrated in animal models and in prospective clinical studies. However, most of the literature is either focused on high-risk, apparently healthy patients, or is based on cross sectional studies. Therefore, we tested the hypothesis that serum Lp-PLA2 mass and activity are useful for predicting cardiovascular (CV) events over the coronary atherosclerotic burden and conventional risk factors in high-risk coronary artery disease patients. METHODS AND RESULTS: In a prospective cohort study of 712 Caucasian patients, who underwent coronary angiography and measurement of both Lp-PLA2 mass and activity at baseline, we determined incident CV events at follow-up after splitting the patients into a high and a low Lp-PLA2 mass and activity groups based on ROC analysis and Youden index. Kaplan-Meier and propensity score matching analysis were used to compare CV event-free survival between groups. Follow-up data were obtained in 75% of the cohort after a median of 7.2 years (range 1-12.7 years) during which 129 (25.5%) CV events were observed. The high Lp-PLA2 activity patients showed worse CV event-free survival (66.7% vs. 79.5%, p=0.023) and acute coronary syndrome-free survival (75.4% vs. 85.6%, p=0.04) than those in low Lp-PLA2 group. CONCLUSIONS: A high Lp-PLA2 activity implies a worse CV prognosis at long term follow up in high-risk Caucasian patients referred for coronary angiography. |
PubMedSearch : Maiolino_2012_PLoS.One_7_e48171 |
PubMedID: 23118945 |
Gene_locus related to this paper: human-PLA2G7 |
Gene_locus | human-PLA2G7 |
Maiolino G, Pedon L, Cesari M, Frigo AC, Wolfert RL, Barisa M, Pagliani L, Rossitto G, Seccia TM, Zanchetta M, Rossi GP (2012)
Lipoprotein-associated phospholipase A2 activity predicts cardiovascular events in high risk coronary artery disease patients
PLoS ONE
7 :e48171
Maiolino G, Pedon L, Cesari M, Frigo AC, Wolfert RL, Barisa M, Pagliani L, Rossitto G, Seccia TM, Zanchetta M, Rossi GP (2012)
PLoS ONE
7 :e48171