| Title : Characterization of hemolytic activity of 3-alkylpyridinium polymers from the marine sponge Reniera sarai - Malovrh_1999_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_124_221 |
| Author(s) : Malovrh P , Sepcic K , Turk T , Macek P |
| Ref : Comparative Biochemistry & Physiology C Pharmacol Toxicol Endocrinol , 124 :221 , 1999 |
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Abstract :
Polymeric alkylpyridinium salts (poly-APS) isolated from the marine sponge Reniera sarai act as potent anticholinesterase agents; in addition they show moderate hemolytic and cytotoxic activities. The hemolytic activity of poly-APS is due to their detergent-like structure and behavior in aqueous solutions. In this work, the hemolytic activity of poly-APS is analyzed and compared to that of structurally-related monomeric cationic surfactants. The influence of different divalent cations and lipids on poly-APS induced hemolysis is discussed. The dimensions of lesions caused by poly-APS in erythrocyte membranes are determined by the use of osmotic protectants. Finally, the possible role of poly-APS in their natural environment is proposed. |
| PubMedSearch : Malovrh_1999_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_124_221 |
| PubMedID: 10622439 |
| Inhibitor | 3-Alkylpyridinium-Polymers |
Malovrh P, Sepcic K, Turk T, Macek P (1999)
Characterization of hemolytic activity of 3-alkylpyridinium polymers from the marine sponge Reniera sarai
Comparative Biochemistry & Physiology C Pharmacol Toxicol Endocrinol
124 :221
Malovrh P, Sepcic K, Turk T, Macek P (1999)
Comparative Biochemistry & Physiology C Pharmacol Toxicol Endocrinol
124 :221