Mather_2013_Science_341_1514

Reference

Title : Distinguishable epidemics of multidrug-resistant Salmonella Typhimurium DT104 in different hosts - Mather_2013_Science_341_1514
Author(s) : Mather AE , Reid SW , Maskell DJ , Parkhill J , Fookes MC , Harris SR , Brown DJ , Coia JE , Mulvey MR , Gilmour MW , Petrovska L , de Pinna E , Kuroda M , Akiba M , Izumiya H , Connor TR , Suchard MA , Lemey P , Mellor DJ , Haydon DT , Thomson NR
Ref : Science , 341 :1514 , 2013
Abstract :

The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance.

PubMedSearch : Mather_2013_Science_341_1514
PubMedID: 24030491

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Citations formats

Mather AE, Reid SW, Maskell DJ, Parkhill J, Fookes MC, Harris SR, Brown DJ, Coia JE, Mulvey MR, Gilmour MW, Petrovska L, de Pinna E, Kuroda M, Akiba M, Izumiya H, Connor TR, Suchard MA, Lemey P, Mellor DJ, Haydon DT, Thomson NR (2013)
Distinguishable epidemics of multidrug-resistant Salmonella Typhimurium DT104 in different hosts
Science 341 :1514

Mather AE, Reid SW, Maskell DJ, Parkhill J, Fookes MC, Harris SR, Brown DJ, Coia JE, Mulvey MR, Gilmour MW, Petrovska L, de Pinna E, Kuroda M, Akiba M, Izumiya H, Connor TR, Suchard MA, Lemey P, Mellor DJ, Haydon DT, Thomson NR (2013)
Science 341 :1514