Title : Neuromuscular blocking actions of the aminoglycoside antibiotics sisomicin and micronomicin in the rabbit - Matsukawa_1997_Tohoku.J.Exp.Med_181_471 |
Author(s) : Matsukawa S , Suh JH , Hashimoto Y , Kato M , Satoh D , Saito S , Endo K , Saishu T |
Ref : Tohoku J Exp Med , 181 :471 , 1997 |
Abstract :
The neuromuscular blocking actions of sisomicin sulfate (SISO), micronomicin sulfate (MCR) and d-tubocurarine (dTc) were studied in 20 rabbits anesthetized with halothane. The i.v. administration of SISO 20-40 mg/kg, MCR 40-80 mg/kg or dTc 0.1-0.3 mg/kg resulted in dose-dependent decreases in twitch tension. The ED50s for SISO, MCR and dTc were 23.5, 58.2 and 0.2 mg/kg, respectively. SISO- and MCR-induced neuromuscular blockade was partially antagonized by neostigmine or by calcium. |
PubMedSearch : Matsukawa_1997_Tohoku.J.Exp.Med_181_471 |
PubMedID: 9210254 |
Matsukawa S, Suh JH, Hashimoto Y, Kato M, Satoh D, Saito S, Endo K, Saishu T (1997)
Neuromuscular blocking actions of the aminoglycoside antibiotics sisomicin and micronomicin in the rabbit
Tohoku J Exp Med
181 :471
Matsukawa S, Suh JH, Hashimoto Y, Kato M, Satoh D, Saito S, Endo K, Saishu T (1997)
Tohoku J Exp Med
181 :471