Meirer_2013_J.Med.Chem_56_1777

Reference

Title : Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase - Meirer_2013_J.Med.Chem_56_1777
Author(s) : Meirer K , Rodl CB , Wisniewska JM , George S , Hafner AK , Buscato EL , Klingler FM , Hahn S , Berressem D , Wittmann SK , Steinhilber D , Hofmann B , Proschak E
Ref : Journal of Medicinal Chemistry , 56 :1777 , 2013
Abstract :

Current research leads to the assumption that drugs affecting more than one target could result in a more efficient treatment of diseases and fewer safety concerns. Administration of drugs inhibiting only one branch of the arachidonic acid cascade is usually accompanied by side effects. We therefore designed and synthesized a library of hybrid molecules incorporating an imidazo[1,2-a]pyridine and an urea moiety as novel soluble epoxide hydrolase (sEH)/5-lipoxygenase (5-LO) dual inhibitors. Evaluation of the compounds was accomplished by in vitro testing using recombinant enzyme assays.

PubMedSearch : Meirer_2013_J.Med.Chem_56_1777
PubMedID: 23356879

Related information

Citations formats

Meirer K, Rodl CB, Wisniewska JM, George S, Hafner AK, Buscato EL, Klingler FM, Hahn S, Berressem D, Wittmann SK, Steinhilber D, Hofmann B, Proschak E (2013)
Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase
Journal of Medicinal Chemistry 56 :1777

Meirer K, Rodl CB, Wisniewska JM, George S, Hafner AK, Buscato EL, Klingler FM, Hahn S, Berressem D, Wittmann SK, Steinhilber D, Hofmann B, Proschak E (2013)
Journal of Medicinal Chemistry 56 :1777