Title : Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase - Meirer_2013_J.Med.Chem_56_1777 |
Author(s) : Meirer K , Rodl CB , Wisniewska JM , George S , Hafner AK , Buscato EL , Klingler FM , Hahn S , Berressem D , Wittmann SK , Steinhilber D , Hofmann B , Proschak E |
Ref : Journal of Medicinal Chemistry , 56 :1777 , 2013 |
Abstract :
Current research leads to the assumption that drugs affecting more than one target could result in a more efficient treatment of diseases and fewer safety concerns. Administration of drugs inhibiting only one branch of the arachidonic acid cascade is usually accompanied by side effects. We therefore designed and synthesized a library of hybrid molecules incorporating an imidazo[1,2-a]pyridine and an urea moiety as novel soluble epoxide hydrolase (sEH)/5-lipoxygenase (5-LO) dual inhibitors. Evaluation of the compounds was accomplished by in vitro testing using recombinant enzyme assays. |
PubMedSearch : Meirer_2013_J.Med.Chem_56_1777 |
PubMedID: 23356879 |
Meirer K, Rodl CB, Wisniewska JM, George S, Hafner AK, Buscato EL, Klingler FM, Hahn S, Berressem D, Wittmann SK, Steinhilber D, Hofmann B, Proschak E (2013)
Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase
Journal of Medicinal Chemistry
56 :1777
Meirer K, Rodl CB, Wisniewska JM, George S, Hafner AK, Buscato EL, Klingler FM, Hahn S, Berressem D, Wittmann SK, Steinhilber D, Hofmann B, Proschak E (2013)
Journal of Medicinal Chemistry
56 :1777