| Title : Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator - Dotsch_2024_J.Med.Chem__ |
| Author(s) : Dotsch L , Davies C , Hennes E , Schonfeld J , Kumar A , Guita C , Ehrler JHM , Hiesinger K , Thavam S , Janning P , Sievers S , Knapp S , Proschak E , Ziegler S , Waldmann H |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Dotsch_2024_J.Med.Chem__ |
| PubMedID: 38470246 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Photosensitization enables Pauson-Khand-type reactions with nitrenes - Li_2024_Science_383_498 |
| Author(s) : Li F , Zhu WF , Empel C , Datsenko O , Kumar A , Xu Y , Ehrler JHM , Atodiresei I , Knapp S , Mykhailiuk PK , Proschak E , Koenigs RM |
| Ref : Science , 383 :498 , 2024 |
| Abstract : |
| PubMedSearch : Li_2024_Science_383_498 |
| PubMedID: 38301027 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells - Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| Author(s) : Brunst S , Schonfeld J , Breunig P , Burgers LD , DeMeglio M , Ehrler JHM , Lillich FF , Weizel L , Hefendehl JK , Furst R , Proschak E , Hiesinger K |
| Ref : ACS Med Chem Lett , 13 :1062 , 2022 |
| Abstract : |
| PubMedSearch : Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| PubMedID: 35859883 |
| Title : Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH\/PPARgamma Modulator - Hartmann_2021_J.Med.Chem_64_2815 |
| Author(s) : Hartmann M , Bibli SI , Tews D , Ni X , Kircher T , Kramer JS , Kilu W , Heering J , Hernandez-Olmos V , Weizel L , Scriba GKE , Krait S , Knapp S , Chaikuad A , Merk D , Fleming I , Fischer-Posovszky P , Proschak E |
| Ref : Journal of Medicinal Chemistry , 64 :2815 , 2021 |
| Abstract : |
| PubMedSearch : Hartmann_2021_J.Med.Chem_64_2815 |
| PubMedID: 33620196 |
| Title : Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor gamma Agonists\/Soluble Epoxide Hydrolase Inhibitors - Lillich_2021_J.Med.Chem_64_17259 |
| Author(s) : Lillich FF , Willems S , Ni X , Kilu W , Borkowsky C , Brodsky M , Kramer JS , Brunst S , Hernandez-Olmos V , Heering J , Schierle S , Kestner RI , Mayser FM , Helmstadter M , Gobel T , Weizel L , Namgaladze D , Kaiser A , Steinhilber D , Pfeilschifter W , Kahnt AS , Proschak A , Chaikuad A , Knapp S , Merk D , Proschak E |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Lillich_2021_J.Med.Chem_64_17259 |
| PubMedID: 34818007 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Dual Soluble Epoxide Hydrolase Inhibitor\/PPAR-gamma Agonist Attenuates Renal Fibrosis - Stavniichuk_2020_Prostaglandins.Other.Lipid.Mediat__106472 |
| Author(s) : Stavniichuk A , Hye Khan MA , Yeboah MM , Chesnik MA , Jankiewicz WK , Hartmann M , Blocher R , Kircher T , Savchuk O , Proschak E , Imig JD |
| Ref : Prostaglandins Other Lipid Mediat , :106472 , 2020 |
| Abstract : |
| PubMedSearch : Stavniichuk_2020_Prostaglandins.Other.Lipid.Mediat__106472 |
| PubMedID: 32569747 |
| Title : Soluble epoxide hydrolase inhibitors with carboranes as non-natural 3-D pharmacophores - Scholz_2020_Eur.J.Med.Chem_185_111766 |
| Author(s) : Scholz MS , Wingen LM , Brunst S , Wittmann SK , Cardoso ILA , Weizel L , Proschak E |
| Ref : Eur Journal of Medicinal Chemistry , 185 :111766 , 2020 |
| Abstract : |
| PubMedSearch : Scholz_2020_Eur.J.Med.Chem_185_111766 |
| PubMedID: 31677445 |
| Title : Multi-Target Approaches in Metabolic Syndrome - Lillich_2020_Front.Pharmacol_11_554961 |
| Author(s) : Lillich FF , Imig JD , Proschak E |
| Ref : Front Pharmacol , 11 :554961 , 2020 |
| Abstract : |
| PubMedSearch : Lillich_2020_Front.Pharmacol_11_554961 |
| PubMedID: 33776749 |
| Title : Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase - Hefke_2020_ACS.Med.Chem.Lett_11_1244 |
| Author(s) : Hefke L , Hiesinger K , Zhu WF , Kramer JS , Proschak E |
| Ref : ACS Med Chem Lett , 11 :1244 , 2020 |
| Abstract : |
| PubMedSearch : Hefke_2020_ACS.Med.Chem.Lett_11_1244 |
| PubMedID: 32551007 |
| Title : Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase - Hiesinger_2020_J.Med.Chem_63_11498 |
| Author(s) : Hiesinger K , Kramer JS , Beyer S , Eckes T , Brunst S , Flauaus C , Wittmann SK , Weizel L , Kaiser A , Kretschmer SBM , George S , Angioni C , Heering J , Geisslinger G , Schubert-Zsilavecz M , Schmidtko A , Pogoryelov D , Pfeilschifter J , Hofmann B , Steinhilber D , Schwalm S , Proschak E |
| Ref : Journal of Medicinal Chemistry , 63 :11498 , 2020 |
| Abstract : |
| PubMedSearch : Hiesinger_2020_J.Med.Chem_63_11498 |
| PubMedID: 33044073 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase - Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| Author(s) : Hiesinger K , Schott A , Kramer JS , Blocher R , Witt F , Wittmann SK , Steinhilber D , Pogoryelov D , Gerstmeier J , Werz O , Proschak E |
| Ref : ACS Med Chem Lett , 11 :298 , 2020 |
| Abstract : |
| PubMedSearch : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| PubMedID: 32184960 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity - Hiesinger_2019_Prostaglandins.Other.Lipid.Mediat_140_31 |
| Author(s) : Hiesinger K , Wagner KM , Hammock BD , Proschak E , Hwang SH |
| Ref : Prostaglandins Other Lipid Mediat , 140 :31 , 2019 |
| Abstract : |
| PubMedSearch : Hiesinger_2019_Prostaglandins.Other.Lipid.Mediat_140_31 |
| PubMedID: 30593866 |
| Title : Computer-Aided Selective Optimization of Side Activities of Talinolol - Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| Author(s) : Hiesinger K , Kramer JS , Achenbach J , Moser D , Weber J , Wittmann SK , Morisseau C , Angioni C , Geisslinger G , Kahnt AS , Kaiser A , Proschak A , Steinhilber D , Pogoryelov D , Wagner K , Hammock BD , Proschak E |
| Ref : ACS Med Chem Lett , 10 :899 , 2019 |
| Abstract : |
| PubMedSearch : Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| PubMedID: 31223445 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor gamma - Gobel_2019_Front.Pharmacol_10_263 |
| Author(s) : Gobel T , Diehl O , Heering J , Merk D , Angioni C , Wittmann SK , Buscato E , Kottke R , Weizel L , Schader T , Maier TJ , Geisslinger G , Schubert-Zsilavecz M , Steinhilber D , Proschak E , Kahnt AS |
| Ref : Front Pharmacol , 10 :263 , 2019 |
| Abstract : |
| PubMedSearch : Gobel_2019_Front.Pharmacol_10_263 |
| PubMedID: 30949053 |
| Title : Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain - Kramer_2019_J.Med.Chem_62_8443 |
| Author(s) : Kramer JS , Woltersdorf S , Duflot T , Hiesinger K , Lillich FF , Knoll F , Wittmann SK , Klingler FM , Brunst S , Chaikuad A , Morisseau C , Hammock BD , Buccellati C , Sala A , Rovati GE , Leuillier M , Fraineau S , Rondeaux J , Hernandez-Olmos V , Heering J , Merk D , Pogoryelov D , Steinhilber D , Knapp S , Bellien J , Proschak E |
| Ref : Journal of Medicinal Chemistry , 62 :8443 , 2019 |
| Abstract : |
| PubMedSearch : Kramer_2019_J.Med.Chem_62_8443 |
| PubMedID: 31436984 |
| Title : Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase - Lukin_2018_Bioorg.Chem_80_655 |
| Author(s) : Lukin A , Kramer J , Hartmann M , Weizel L , Hernandez-Olmos V , Falahati K , Burghardt I , Kalinchenkova N , Bagnyukova D , Zhurilo N , Rautio J , Forsberg M , Ihalainen J , Auriola S , Leppanen J , Konstantinov I , Pogoryelov D , Proschak E , Dar'in D , Krasavin M |
| Ref : Bioorg Chem , 80 :655 , 2018 |
| Abstract : |
| PubMedSearch : Lukin_2018_Bioorg.Chem_80_655 |
| PubMedID: 30059891 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Orally Available Soluble Epoxide Hydrolase\/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain - Blocher_2018_J.Med.Chem_61_3541 |
| Author(s) : Blocher R , Wagner KM , Gopireddy RR , Harris TR , Wu H , Barnych B , Hwang SH , Xiang YK , Proschak E , Morisseau C , Hammock BD |
| Ref : Journal of Medicinal Chemistry , 61 :3541 , 2018 |
| Abstract : |
| PubMedSearch : Blocher_2018_J.Med.Chem_61_3541 |
| PubMedID: 29614224 |
| Title : Phosphatase activity of soluble epoxide hydrolase - Kramer_2017_Prostaglandins.Other.Lipid.Mediat_133_88 |
| Author(s) : Kramer J , Proschak E |
| Ref : Prostaglandins Other Lipid Mediat , 133 :88 , 2017 |
| Abstract : |
| PubMedSearch : Kramer_2017_Prostaglandins.Other.Lipid.Mediat_133_88 |
| PubMedID: 28729091 |
| Title : Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases - Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| Author(s) : Bautista-Aguilera OM , Hagenow S , Palomino-Antolin A , Farre-Alins V , Ismaili L , Joffrin PL , Jimeno ML , Soukup O , Janockova J , Kalinowsky L , Proschak E , Iriepa I , Moraleda I , Schwed JS , Romero Martinez A , Lopez-Munoz F , Chioua M , Egea J , Ramsay RR , Marco-Contelles J , Stark H |
| Ref : Angew Chem Int Ed Engl , 56 :12765 , 2017 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedID: 28861918 |
| Title : A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis - Schmidt_2017_J.Med.Chem_60_7703 |
| Author(s) : Schmidt J , Rotter M , Weiser T , Wittmann S , Weizel L , Kaiser A , Heering J , Goebel T , Angioni C , Wurglics M , Paulke A , Geisslinger G , Kahnt A , Steinhilber D , Proschak E , Merk D |
| Ref : Journal of Medicinal Chemistry , 60 :7703 , 2017 |
| Abstract : |
| PubMedSearch : Schmidt_2017_J.Med.Chem_60_7703 |
| PubMedID: 28845983 |
| Title : N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase\/Peroxisome Proliferator-Activated Receptor gamma Modulators - Blocher_2016_J.Med.Chem_59_61 |
| Author(s) : Blocher R , Lamers C , Wittmann SK , Merk D , Hartmann M , Weizel L , Diehl O , Bruggerhoff A , Boss M , Kaiser A , Schader T , Gobel T , Grundmann M , Angioni C , Heering J , Geisslinger G , Wurglics M , Kostenis E , Brune B , Steinhilber D , Schubert-Zsilavecz M , Kahnt AS , Proschak E |
| Ref : Journal of Medicinal Chemistry , 59 :61 , 2016 |
| Abstract : |
| PubMedSearch : Blocher_2016_J.Med.Chem_59_61 |
| PubMedID: 26595749 |
| Title : Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase - Meirer_2016_Molecules_22_ |
| Author(s) : Meirer K , Glatzel D , Kretschmer S , Wittmann SK , Hartmann M , Blocher R , Angioni C , Geisslinger G , Steinhilber D , Hofmann B , Furst R , Proschak E |
| Ref : Molecules , 22 : , 2016 |
| Abstract : |
| PubMedSearch : Meirer_2016_Molecules_22_ |
| PubMedID: 28036068 |
| Title : Exploring the chemical space of multitarget ligands using aligned self-organizing maps - Achenbach_2013_ACS.Med.Chem.Lett_4_1169 |
| Author(s) : Achenbach J , Klingler FM , Blocher R , Moser D , Hafner AK , Rodl CB , Kretschmer S , Kruger B , Lohr F , Stark H , Hofmann B , Steinhilber D , Proschak E |
| Ref : ACS Med Chem Lett , 4 :1169 , 2013 |
| Abstract : |
| PubMedSearch : Achenbach_2013_ACS.Med.Chem.Lett_4_1169 |
| PubMedID: 24900624 |
| Title : Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase - Meirer_2013_J.Med.Chem_56_1777 |
| Author(s) : Meirer K , Rodl CB , Wisniewska JM , George S , Hafner AK , Buscato EL , Klingler FM , Hahn S , Berressem D , Wittmann SK , Steinhilber D , Hofmann B , Proschak E |
| Ref : Journal of Medicinal Chemistry , 56 :1777 , 2013 |
| Abstract : |
| PubMedSearch : Meirer_2013_J.Med.Chem_56_1777 |
| PubMedID: 23356879 |
| Title : Evaluation of structure-derived pharmacophore of soluble epoxide hydrolase inhibitors by virtual screening - Moser_2012_Bioorg.Med.Chem.Lett_22_6762 |
| Author(s) : Moser D , Achenbach J , Klingler FM , Estel la B , Hahn S , Proschak E |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :6762 , 2012 |
| Abstract : |
| PubMedSearch : Moser_2012_Bioorg.Med.Chem.Lett_22_6762 |
| PubMedID: 23017883 |