| Title : An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis - Meunier_2015_Nat.Commun_6_7889 |
| Author(s) : Meunier S , Shvedunova M , Van Nguyen N , Avila L , Vernos I , Akhtar A |
| Ref : Nat Commun , 6 :7889 , 2015 |
|
Abstract :
The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle. |
| PubMedSearch : Meunier_2015_Nat.Commun_6_7889 |
| PubMedID: 26243146 |
| Gene_locus related to this paper: human-KANSL3 |
| Gene_locus | human-KANSL3 |
| Family | NLS3-Tex30 |
Meunier S, Shvedunova M, Van Nguyen N, Avila L, Vernos I, Akhtar A (2015)
An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
Nat Commun
6 :7889
Meunier S, Shvedunova M, Van Nguyen N, Avila L, Vernos I, Akhtar A (2015)
Nat Commun
6 :7889