| Title : New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates - Mewshaw_1998_Bioorg.Med.Chem.Lett_8_295 |
| Author(s) : Mewshaw RE , Husbands MG , Gildersleeve ES , Webb MB , Shi X , Mazandarani H , Cockett MI , Ochalski R , Brennan JA , Abou-Gharbia M , Marquis K , McGaughey GB , Coupet J , Andree TH |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :295 , 1998 |
|
Abstract :
Described in this report is a systematic study which led to the identification of two new dopamine D2 partial agonists (5 and 17). Phenols 5 and 17 represent prototypes of two new classes of D2 partial agonists as well as templates for the future design of novel dopaminergic agents. |
| PubMedSearch : Mewshaw_1998_Bioorg.Med.Chem.Lett_8_295 |
| PubMedID: 9871673 |
Mewshaw RE, Husbands MG, Gildersleeve ES, Webb MB, Shi X, Mazandarani H, Cockett MI, Ochalski R, Brennan JA, Abou-Gharbia M, Marquis K, McGaughey GB, Coupet J, Andree TH (1998)
New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates
Bioorganic & Medicinal Chemistry Lett
8 :295
Mewshaw RE, Husbands MG, Gildersleeve ES, Webb MB, Shi X, Mazandarani H, Cockett MI, Ochalski R, Brennan JA, Abou-Gharbia M, Marquis K, McGaughey GB, Coupet J, Andree TH (1998)
Bioorganic & Medicinal Chemistry Lett
8 :295