| Title : Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis - Minami_2011_Org.Lett_13_1638 |
| Author(s) : Minami A , Migita A , Inada D , Hotta K , Watanabe K , Oguri H , Oikawa H |
| Ref : Org Lett , 13 :1638 , 2011 |
|
Abstract :
Our recent findings of the first epoxide hydrolase Lsd19, involved in lasalocid A biosynthesis, led us to investigate a long-standing controversial issue on the mechanism of enzymatic epoxide-opening cascades. The site-directed mutagenesis and domain dissection analysis to reveal the mechanism of the reaction catalyzed by Lsd19 is examined, especially in the role of acidic amino acid pair and catalytic domains. |
| PubMedSearch : Minami_2011_Org.Lett_13_1638 |
| PubMedID: 21375229 |
Minami A, Migita A, Inada D, Hotta K, Watanabe K, Oguri H, Oikawa H (2011)
Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis
Org Lett
13 :1638
Minami A, Migita A, Inada D, Hotta K, Watanabe K, Oguri H, Oikawa H (2011)
Org Lett
13 :1638