Morris_2014_ACS.Chem.Biol_9_1097

Reference

Title : Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia - Morris_2014_ACS.Chem.Biol_9_1097
Author(s) : Morris PJ , Medina-Cleghorn D , Heslin A , King SM , Orr J , Mulvihill MM , Krauss RM , Nomura DK
Ref : ACS Chemical Biology , 9 :1097 , 2014
Abstract :

Humans are prevalently exposed to organophosphorus flame retardants (OPFRs) contained in consumer products and electronics, though their toxicological effects and mechanisms remain poorly understood. We show here that OPFRs inhibit specific liver carboxylesterases (Ces) and cause altered hepatic lipid metabolism. Ablation of the OPFR target Ces1g has been previously linked to dyslipidemia in mice. Consistent with OPFR inhibition of Ces1g, we also observe OPFR-induced serum hypertriglyceridemia in mice. Our findings suggest novel toxicities that may arise from OPFR exposure and highlight the utility of chemoproteomic and metabolomic platforms in the toxicological characterization of environmental chemicals.

PubMedSearch : Morris_2014_ACS.Chem.Biol_9_1097
PubMedID: 24597639

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Citations formats

Morris PJ, Medina-Cleghorn D, Heslin A, King SM, Orr J, Mulvihill MM, Krauss RM, Nomura DK (2014)
Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia
ACS Chemical Biology 9 :1097

Morris PJ, Medina-Cleghorn D, Heslin A, King SM, Orr J, Mulvihill MM, Krauss RM, Nomura DK (2014)
ACS Chemical Biology 9 :1097