| Title : Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives - Nadri_2010_Bioorg.Med.Chem_18_6360 |
| Author(s) : Nadri H , Pirali-Hamedani M , Shekarchi M , Abdollahi M , Sheibani V , Amanlou M , Shafiee A , Foroumadi A |
| Ref : Bioorganic & Medicinal Chemistry , 18 :6360 , 2010 |
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Abstract :
A novel series of benzofuranone-ylidene-methyl benzylpyridinium derivatives (6a-u) were synthesized as acetylcholinesterase inhibitors. The anticholinesterase activity of synthesized compounds was measured using colorimetric Ellman's method. It was revealed that some synthesized compounds exhibited high anticholinesterase activity, among them compound 6b was the most active compound (IC(50)=10 + or - 6.87 nM). |
| PubMedSearch : Nadri_2010_Bioorg.Med.Chem_18_6360 |
| PubMedID: 20673725 |
| Inhibitor | Aurone-Donepezil-Cpd6b |
Nadri H, Pirali-Hamedani M, Shekarchi M, Abdollahi M, Sheibani V, Amanlou M, Shafiee A, Foroumadi A (2010)
Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives
Bioorganic & Medicinal Chemistry
18 :6360
Nadri H, Pirali-Hamedani M, Shekarchi M, Abdollahi M, Sheibani V, Amanlou M, Shafiee A, Foroumadi A (2010)
Bioorganic & Medicinal Chemistry
18 :6360