Aurone-Donepezil-Cpd6b
6b was the most active compound IC50 = 10 +/- 6.87 nM
General
Type : Flavonoid, Benzofuran, Multitarget, Derivative of Donepezil
Chemical_Nomenclature :
Canonical SMILES :
InChI :
InChIKey :
Other name(s) : (2Z)-2-[[1-[(2-fluorophenyl)methyl]pyridin-1-ium-4-yl]methylidene]-6-methoxy-1-benzofuran-3-one\;chloride || Compound 6b || CHEMBL1223029 || CHEMBL1229113 || BDBM50325191 || (Z)-1-(2-Fluorobenzyl)-4-((6-methoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride
Target
References (1)
| Title : Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives - Nadri_2010_Bioorg.Med.Chem_18_6360 |
| Author(s) : Nadri H , Pirali-Hamedani M , Shekarchi M , Abdollahi M , Sheibani V , Amanlou M , Shafiee A , Foroumadi A |
| Ref : Bioorganic & Medicinal Chemistry , 18 :6360 , 2010 |
| Abstract : |
| PubMedSearch : Nadri_2010_Bioorg.Med.Chem_18_6360 |
| PubMedID: 20673725 |