Title : Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients - Nakajima_2005_Eur.J.Clin.Pharmacol_61_25 |
Author(s) : Nakajima Y , Saito Y , Shiseki K , Fukushima-Uesaka H , Hasegawa R , Ozawa S , Sugai K , Katoh M , Saitoh O , Ohnuma T , Kawai M , Ohtsuki T , Suzuki C , Minami N , Kimura H , Goto Y , Kamatani N , Kaniwa N , Sawada J |
Ref : European Journal of Clinical Pharmacology , 61 :25 , 2005 |
Abstract :
OBJECTIVE: Microsomal epoxide hydrolase (mEH) is an enzyme that detoxifies reactive epoxides and catalyzes the biotransformation of carbamazepine-10,11-epoxide (CBZ-epoxide) to carbamazepine-10,11-diol (CBZ-diol). Utilizing single nucleotide polymorphisms (SNPs) of the EPHX1 gene encoding mEH, we identified the haplotypes of EPHX1 blocks and investigated the association between the block haplotypes and CBZ-epoxide metabolism. |
PubMedSearch : Nakajima_2005_Eur.J.Clin.Pharmacol_61_25 |
PubMedID: 15692831 |
Substrate | Carbamazepine-10,11-epoxide |
Nakajima Y, Saito Y, Shiseki K, Fukushima-Uesaka H, Hasegawa R, Ozawa S, Sugai K, Katoh M, Saitoh O, Ohnuma T, Kawai M, Ohtsuki T, Suzuki C, Minami N, Kimura H, Goto Y, Kamatani N, Kaniwa N, Sawada J (2005)
Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients
European Journal of Clinical Pharmacology
61 :25
Nakajima Y, Saito Y, Shiseki K, Fukushima-Uesaka H, Hasegawa R, Ozawa S, Sugai K, Katoh M, Saitoh O, Ohnuma T, Kawai M, Ohtsuki T, Suzuki C, Minami N, Kimura H, Goto Y, Kamatani N, Kaniwa N, Sawada J (2005)
European Journal of Clinical Pharmacology
61 :25