| Title : Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus - Niemi_1995_J.Bacteriol_177_2942 |
| Author(s) : Niemi J , Mantsala P |
| Ref : Journal of Bacteriology , 177 :2942 , 1995 |
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Abstract :
Six open reading frames, rdmA to rdmF, in a 6,077-bp segment of Streptomyces purpurascens DNA which caused the production of hybrid anthracyclines were identified. The minimal fragment that produced anthracyclines modified at the 10th position contained rdmB to rdmD; rdmE is the gene for aklavinone-11-hydroxylase. RdmC is similar to a putative open reading frame in the daunorubicin biosynthetic cluster of Streptomyces peucetius and is likely to participate in the removal of the side chain at the 10th position. |
| PubMedSearch : Niemi_1995_J.Bacteriol_177_2942 |
| PubMedID: 7751313 |
| Gene_locus related to this paper: strpu-rdmC |
| Gene_locus | strpu-rdmC |
Niemi J, Mantsala P (1995)
Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus
Journal of Bacteriology
177 :2942
Niemi J, Mantsala P (1995)
Journal of Bacteriology
177 :2942