| Title : Sarin-like and soman-like organophosphorous agents activate PLCgamma in rat brains - Niijima_1999_Toxicol.Appl.Pharmacol_156_64 |
| Author(s) : Niijima H , Nagao M , Nakajima M , Takatori T , Matsuda Y , Iwase H , Kobayashi M |
| Ref : Toxicol Appl Pharmacol , 156 :64 , 1999 |
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Abstract :
We report that there is a time-related change in the phospholipase C (PLC) activities of rat brain cytosol and membrane fractions after iv injection of a soman-like or a sarin-like organophosphorous agent (bis(isopropyl methyl)phosphonate [BIMP] and bis(pinacolyl methyl)phosphonate [BPMP]). PLCgamma was activated in the brain cytosol fraction from BPMP-injected rats. The phosphorylating activity of rat brain membrane fractions were enhanced by BPMP treatment. The brain membrane fractions from BPMP-treated rats phosphorylated several proteins, including supposedly PLCgamma in the brain cytosol fraction from control rats in vitro. These results suggest that soman and sarin may stimulate a membrane tyrosine kinase, including growth factor receptors, directly or indirectly. |
| PubMedSearch : Niijima_1999_Toxicol.Appl.Pharmacol_156_64 |
| PubMedID: 10101100 |
Niijima H, Nagao M, Nakajima M, Takatori T, Matsuda Y, Iwase H, Kobayashi M (1999)
Sarin-like and soman-like organophosphorous agents activate PLCgamma in rat brains
Toxicol Appl Pharmacol
156 :64
Niijima H, Nagao M, Nakajima M, Takatori T, Matsuda Y, Iwase H, Kobayashi M (1999)
Toxicol Appl Pharmacol
156 :64