BIMP

BIMP has the same phosphonate group as sarin and similar anti-acetylcholinesterase (AChE) activity to that of sarin (IC50 = 3.9 nM in bovine erythrocyte AChE

General

Type : Derivative of Sarin, Organophosphate, Surrogate OP, Nerve Agent G-series

Chemical_Nomenclature : 2-[methyl-[methyl(propan-2-yloxy)phosphoryl]oxyphosphoryl]oxypropane

Canonical SMILES : CC(C)OP(=O)(C)OP(=O)(C)OC(C)C

InChI : InChI=1S\/C8H20O5P2\/c1-7(2)11-14(5,9)13-15(6,10)12-8(3)4\/h7-8H,1-6H3

InChIKey : SAVYTRKCUVDEFC-UHFFFAOYSA-N

Other name(s) : Diisopropyl dimethylpyrophosphonate  ||  AC1LCHGR  ||  SCHEMBL12705386  ||  Methylphosphonic acid, anhydride, bis(isopropyl) ester


MW : 258.18

Formula : C8H20O5P2

CAS_number :

PubChem : 600301

UniChem : SAVYTRKCUVDEFC-UHFFFAOYSA-N

Target

Families : BIMP ligand of proteins in family
ACHE BCHE

References (5)

Title : BIMP affects tubulin structure and causes abnormalities in cell division - Murata_2021_Leg.Med.(Tokyo)_53_101929
Author(s) : Murata K , Yoshikawa N , Yoshimoto K , Namera A , Takeshita H , Nagao M
Ref : Leg Med (Tokyo) , 53 :101929 , 2021
Abstract :
PubMedSearch : Murata_2021_Leg.Med.(Tokyo)_53_101929
PubMedID: 34225093

Title : The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells - Arima_2016_J.Toxicol.Sci_41_617
Author(s) : Arima Y , Shiraishi H , Saito A , Yoshimoto K , Namera A , Makita R , Murata K , Imaizumi K , Nagao M
Ref : Journal of Toxicological Sciences , 41 :617 , 2016
Abstract :
PubMedSearch : Arima_2016_J.Toxicol.Sci_41_617
PubMedID: 27665771

Title : Acute effects of a sarin-like organophosphorus agent, bis(isopropyl methyl)phosphonate, on cardiovascular parameters in anaesthetized, artificially ventilated rats - Watanabe_2013_Toxicol.Appl.Pharmacol_272_61
Author(s) : Watanabe Y , Itoh T , Shiraishi H , Maeno Y , Arima Y , Torikoshi A , Namera A , Makita R , Yoshizumi M , Nagao M
Ref : Toxicol Appl Pharmacol , 272 :61 , 2013
Abstract :
PubMedSearch : Watanabe_2013_Toxicol.Appl.Pharmacol_272_61
PubMedID: 23769715

Title : Sarin-like and soman-like organophosphorous agents activate PLCgamma in rat brains - Niijima_1999_Toxicol.Appl.Pharmacol_156_64
Author(s) : Niijima H , Nagao M , Nakajima M , Takatori T , Matsuda Y , Iwase H , Kobayashi M
Ref : Toxicol Appl Pharmacol , 156 :64 , 1999
Abstract :
PubMedSearch : Niijima_1999_Toxicol.Appl.Pharmacol_156_64
PubMedID: 10101100

Title : Detection of sarin hydrolysis products from sarin-like organophosphorus agent-exposed human erythrocytes - Nagao_1997_J.Chromatogr.B.Biomed.Sci.Appl_701_9
Author(s) : Nagao M , Takatori T , Matsuda Y , Nakajima M , Niijima H , Iwase H , Iwadate K , Amano T
Ref : Journal of Chromatography B Biomed Sci Appl , 701 :9 , 1997
Abstract :
PubMedSearch : Nagao_1997_J.Chromatogr.B.Biomed.Sci.Appl_701_9
PubMedID: 9389333