BIMP
BIMP has the same phosphonate group as sarin and similar anti-acetylcholinesterase (AChE) activity to that of sarin (IC50 = 3.9 nM in bovine erythrocyte AChE
General
Type : Derivative of Sarin, Organophosphate, Surrogate OP, Nerve Agent G-series
Chemical_Nomenclature : 2-[methyl-[methyl(propan-2-yloxy)phosphoryl]oxyphosphoryl]oxypropane
Canonical SMILES : CC(C)OP(=O)(C)OP(=O)(C)OC(C)C
InChI : InChI=1S\/C8H20O5P2\/c1-7(2)11-14(5,9)13-15(6,10)12-8(3)4\/h7-8H,1-6H3
InChIKey : SAVYTRKCUVDEFC-UHFFFAOYSA-N
Other name(s) : Diisopropyl dimethylpyrophosphonate || AC1LCHGR || SCHEMBL12705386 || Methylphosphonic acid, anhydride, bis(isopropyl) ester
References (5)
| Title : BIMP affects tubulin structure and causes abnormalities in cell division - Murata_2021_Leg.Med.(Tokyo)_53_101929 |
| Author(s) : Murata K , Yoshikawa N , Yoshimoto K , Namera A , Takeshita H , Nagao M |
| Ref : Leg Med (Tokyo) , 53 :101929 , 2021 |
| Abstract : |
| PubMedSearch : Murata_2021_Leg.Med.(Tokyo)_53_101929 |
| PubMedID: 34225093 |
| Title : The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells - Arima_2016_J.Toxicol.Sci_41_617 |
| Author(s) : Arima Y , Shiraishi H , Saito A , Yoshimoto K , Namera A , Makita R , Murata K , Imaizumi K , Nagao M |
| Ref : Journal of Toxicological Sciences , 41 :617 , 2016 |
| Abstract : |
| PubMedSearch : Arima_2016_J.Toxicol.Sci_41_617 |
| PubMedID: 27665771 |
| Title : Acute effects of a sarin-like organophosphorus agent, bis(isopropyl methyl)phosphonate, on cardiovascular parameters in anaesthetized, artificially ventilated rats - Watanabe_2013_Toxicol.Appl.Pharmacol_272_61 |
| Author(s) : Watanabe Y , Itoh T , Shiraishi H , Maeno Y , Arima Y , Torikoshi A , Namera A , Makita R , Yoshizumi M , Nagao M |
| Ref : Toxicol Appl Pharmacol , 272 :61 , 2013 |
| Abstract : |
| PubMedSearch : Watanabe_2013_Toxicol.Appl.Pharmacol_272_61 |
| PubMedID: 23769715 |
| Title : Sarin-like and soman-like organophosphorous agents activate PLCgamma in rat brains - Niijima_1999_Toxicol.Appl.Pharmacol_156_64 |
| Author(s) : Niijima H , Nagao M , Nakajima M , Takatori T , Matsuda Y , Iwase H , Kobayashi M |
| Ref : Toxicol Appl Pharmacol , 156 :64 , 1999 |
| Abstract : |
| PubMedSearch : Niijima_1999_Toxicol.Appl.Pharmacol_156_64 |
| PubMedID: 10101100 |
| Title : Detection of sarin hydrolysis products from sarin-like organophosphorus agent-exposed human erythrocytes - Nagao_1997_J.Chromatogr.B.Biomed.Sci.Appl_701_9 |
| Author(s) : Nagao M , Takatori T , Matsuda Y , Nakajima M , Niijima H , Iwase H , Iwadate K , Amano T |
| Ref : Journal of Chromatography B Biomed Sci Appl , 701 :9 , 1997 |
| Abstract : |
| PubMedSearch : Nagao_1997_J.Chromatogr.B.Biomed.Sci.Appl_701_9 |
| PubMedID: 9389333 |