| Title : Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors - O'Connor_2010_Bioorg.Med.Chem.Lett_20_6273 |
| Author(s) : O'Connor SP , Wang Y , Simpkins LM , Brigance RP , Meng W , Wang A , Kirby MS , Weigelt CA , Hamann LG |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :6273 , 2010 |
|
Abstract :
The synthesis and SAR of aminomethyl-substituted imidazolopyrimidine DPP4 inhibitors bearing varied pendant aryl groups is described. Compound 1, which exists as a separable mixture of non-interconvertible atropisomers was used as the starting point for investigation. The effects of substituent pattern and type as well as stereochemical effects on inhibitor potency are discussed. |
| PubMedSearch : O'Connor_2010_Bioorg.Med.Chem.Lett_20_6273 |
| PubMedID: 20833042 |
O'Connor SP, Wang Y, Simpkins LM, Brigance RP, Meng W, Wang A, Kirby MS, Weigelt CA, Hamann LG (2010)
Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors
Bioorganic & Medicinal Chemistry Lett
20 :6273
O'Connor SP, Wang Y, Simpkins LM, Brigance RP, Meng W, Wang A, Kirby MS, Weigelt CA, Hamann LG (2010)
Bioorganic & Medicinal Chemistry Lett
20 :6273