Title : High-resolution structure of human apo dipeptidyl peptidase IV\/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine - Oefner_2003_Acta.Crystallogr.D.Biol.Crystallogr_59_1206 |
Author(s) : Oefner C , D'Arcy A , Mac Sweeney A , Pierau S , Gardiner R , Dale GE |
Ref : Acta Crystallographica D Biol Crystallogr , 59 :1206 , 2003 |
Abstract :
Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine protease glycoprotein. The high-resolution crystal structure of the homodimeric human apo dipeptidyl peptidase IV has been determined at 1.9 A resolution. In addition, the structure of the binary complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine has been solved, revealing the nature of the covalent interaction with the active-site serine. |
PubMedSearch : Oefner_2003_Acta.Crystallogr.D.Biol.Crystallogr_59_1206 |
PubMedID: 12832764 |
Gene_locus related to this paper: human-DPP4 |
Gene_locus | human-DPP4 |
Structure | 1PFQ |
Oefner C, D'Arcy A, Mac Sweeney A, Pierau S, Gardiner R, Dale GE (2003)
High-resolution structure of human apo dipeptidyl peptidase IV\/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine
Acta Crystallographica D Biol Crystallogr
59 :1206
Oefner C, D'Arcy A, Mac Sweeney A, Pierau S, Gardiner R, Dale GE (2003)
Acta Crystallographica D Biol Crystallogr
59 :1206