| Title : Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella - Ohta_1998_Chem.Pharm.Bull.(Tokyo)_46_684 |
| Author(s) : Ohta K , Mizushina Y , Hirata N , Takemura M , Sugawara F , Matsukage A , Yoshida S , Sakaguchi K |
| Ref : Chem Pharm Bull (Tokyo) , 46 :684 , 1998 |
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Abstract :
A new sulfolipid, KM043, which belongs to the 6-sulfo-alpha-D-quinovopyranosyl-(1-->3')-1',2'-diacylglycerol (SQDG) class of compounds, has been isolated from a marine red alga, Gigartina tenella, as a potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1. Its structure was determined on the basis of spectroscopic and gas chromatographic analyses. The inhibition was dose-dependent, and complete (more than 90%) inhibition of DNA polymerase alpha (pol. alpha), DNA polymerase beta (pol. beta) and HIV-reverse transcriptase type 1 (HIV-RT) was observed at concentrations of 5, 10, and 30 microM, respectively. |
| PubMedSearch : Ohta_1998_Chem.Pharm.Bull.(Tokyo)_46_684 |
| PubMedID: 9579044 |
| Substrate | KM043 |
Ohta K, Mizushina Y, Hirata N, Takemura M, Sugawara F, Matsukage A, Yoshida S, Sakaguchi K (1998)
Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella
Chem Pharm Bull (Tokyo)
46 :684
Ohta K, Mizushina Y, Hirata N, Takemura M, Sugawara F, Matsukage A, Yoshida S, Sakaguchi K (1998)
Chem Pharm Bull (Tokyo)
46 :684