Olazaran_2012_Dement.Geriatr.Cogn.Dis.Extra_2_400

BACKGROUND Longitudinal reports on the clinical features of patients with Alzheimer's disease AD and concomitant cerebrovascular disease are scarce METHODS We elaborated a working definition of AD with vascular component ADVC and this definition was retrospectively investigated in a cohort of patients with cognitive deterioration who were prescribed a cholinesterase inhibitor during usual practice RESULTS A total of 137 patients with probable AD and 66 patients with ADVC were studied during a mean follow-up period of 2.8 years Univariate analyses demonstrated worse functional evolution and anticipation of psychotic symptoms and agitation in the ADVC group CONCLUSIONS The present results are consistent with an additive model of predominantly frontal-subcortical vascular damage in AD.