| Title : First enzymatic hydrolysis\/thio-Michael addition cascade route to synthesis of AChE inhibitors - Oueis_2014_Chem.Commun.(Camb)_50_2043 |
| Author(s) : Oueis E , Nachon F , Sabot C , Renard PY |
| Ref : Chem Commun (Camb) , 50 :2043 , 2014 |
|
Abstract :
The irreversible Michael addition of thiols to acrylamides is reported as a new tool for the kinetic target-guided synthesis. In an unprecedented enzymatic hydrolysis/thio-Michael addition procedure, potent and selective acetylcholinesterase inhibitors are assembled by the enzyme using both its esterasic and templating ability. |
| PubMedSearch : Oueis_2014_Chem.Commun.(Camb)_50_2043 |
| PubMedID: 24418813 |
Oueis E, Nachon F, Sabot C, Renard PY (2014)
First enzymatic hydrolysis\/thio-Michael addition cascade route to synthesis of AChE inhibitors
Chem Commun (Camb)
50 :2043
Oueis E, Nachon F, Sabot C, Renard PY (2014)
Chem Commun (Camb)
50 :2043