Nachon F

General

Full name : Nachon Florian

First name : Florian

Mail : Departement de Toxicologie, Institut de Recherche Biomedicale des Armees, Bretigny-sur-Orge, F-91223

Zip Code :

City :

Country : France

Email : florian@nachon.net

Phone : +33476636959

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Website :

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References (141)

Title : Unveiling the Full Dynamical and Reactivity Profiles of Acetylcholinesterase: A Comprehensive All-Atom Investigation}, - Celerse_2024_ACS.Catal_14_1785
Author(s) : Celerse F , Lagardre L , Bouchibti Y , Nachon F , Verdier L , Piquemal JP , Derat E
Ref : ACS Catal , 14 :1785 , 2024
Abstract :
PubMedSearch : Celerse_2024_ACS.Catal_14_1785
PubMedID:

Title : The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives - Voros_2024_Chem.Biol.Interact__110973
Author(s) : Voros C , Dias J , Timperley CM , Nachon F , Brown RCD , Baati R
Ref : Chemico-Biological Interactions , :110973 , 2024
Abstract :
PubMedSearch : Voros_2024_Chem.Biol.Interact__110973
PubMedID: 38574837

Title : Warfare Nerve Agents and Paraoxonase-1 as a Potential Prophylactic Therapy against Intoxication - Iyengar_2024_Protein.Pept.Lett__
Author(s) : Iyengar ARS , Khandave PY , Bzdrenga J , Nachon F , Brazzolotto X , Pande AH
Ref : Protein Pept Lett , : , 2024
Abstract :
PubMedSearch : Iyengar_2024_Protein.Pept.Lett__
PubMedID: 38706353

Title : Baseline physiological data from anesthetized pigs in a VX intoxication model - Goulay_2024_Toxicol.Lett__
Author(s) : Goulay R , Femy F , Nervo A , Valentino S , Madi M , Joly AL , Servonnet A , Nachon F , Reymond C , Jaffre N
Ref : Toxicol Lett , : , 2024
Abstract :
PubMedSearch : Goulay_2024_Toxicol.Lett__
PubMedID: 38768837

Title : Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation - Pidany_2023_Eur.J.Med.Chem_252_115301
Author(s) : Pidany F , Kroustkova J , Al Mamun A , Suchankova D , Brazzolotto X , Nachon F , Chantegreil F , Dolezal R , Pulkrabkova L , Muckova L , Hrabinova M , Finger V , Kufa M , Soukup O , Jun D , Jenco J , Kunes J , Novakova L , Korabecny J , Cahlikova L
Ref : Eur Journal of Medicinal Chemistry , 252 :115301 , 2023
Abstract :
PubMedSearch : Pidany_2023_Eur.J.Med.Chem_252_115301
PubMedID: 36996715
Gene_locus related to this paper: human-BCHE

Title : Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies - Jing_2023_Bioorg.Chem_134_106465
Author(s) : Jing L , Wei W , Meng B , Chantegreil F , Nachon F , Martinez A , Wu G , Zhao H , Song Y , Kang D , Brazzolotto X , Zhan P , Liu X
Ref : Bioorg Chem , 134 :106465 , 2023
Abstract :
PubMedSearch : Jing_2023_Bioorg.Chem_134_106465
PubMedID: 36933339
Gene_locus related to this paper: human-BCHE

Title : 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases - Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152
Author(s) : Knez D , Diez-Iriepa D , Chioua M , Gottinger A , Denic M , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Meden A , Pislar A , Kos J , Zakelj S , Stojan J , Salat K , Serrano J , Patricia Fernandez AP , Sanchez-Garcia A , Martinez-Murillo R , Binda C , Lopez-Munoz F , Gobec S , Marco-Contelle J
Ref : Acta Pharmaceutica Sinica B , 13 :2152 , 2023
Abstract :
PubMedSearch : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152
PubMedID: 37250172
Gene_locus related to this paper: human-BCHE

Title : Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies - Panek_2023_Eur.J.Med.Chem_249_115135
Author(s) : Panek D , Pasieka A , Latacz G , Zareba P , Szczech M , Godyn J , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Walczak M , Smolik M , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B
Ref : Eur Journal of Medicinal Chemistry , 249 :115135 , 2023
Abstract :
PubMedSearch : Panek_2023_Eur.J.Med.Chem_249_115135
PubMedID: 36696766
Gene_locus related to this paper: human-BCHE

Title : Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead - Meden_2023_Eur.J.Med.Chem_247_115048
Author(s) : Meden A , Knez D , Brazzolotto X , Modeste F , Perdih A , Pislar A , Zorman M , Zorovic M , Denic M , Pajk S , Zivin M , Nachon F , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 247 :115048 , 2023
Abstract :
PubMedSearch : Meden_2023_Eur.J.Med.Chem_247_115048
PubMedID: 36586299
Gene_locus related to this paper: human-BCHE

Title : From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series - Meden_2022_Eur.J.Med.Chem_230_114248
Author(s) : Meden A , Knez D , Brazzolotto X , Nachon F , Dias J , Svete J , Stojan J , Groselj U , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 230 :114248 , 2022
Abstract :
PubMedSearch : Meden_2022_Eur.J.Med.Chem_230_114248
PubMedID: 35299116

Title : Toxicokinetics of plasmatic VX in a swine model: comparison of a simple enzymatic titration method with a mass spectrometry method - Femy_2022_Arch.Toxicol__
Author(s) : Femy F , Meesemaecker G , Belverge N , Courageux C , Nervo A , Goulay R , Reymond C , Chantegreil F , Madi M , Nachon F , Taudon N , Jaffre N
Ref : Archives of Toxicology , : , 2022
Abstract :
PubMedSearch : Femy_2022_Arch.Toxicol__
PubMedID: 36326899

Title : Grid-type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions - Nachon_2022_Chembiochem_23_e202200456
Author(s) : Nachon F , Brazzolotto X , Dias J , Courageux C , Drozdz W , Cao XY , Stefankiewicz AR , Lehn JM
Ref : Chembiochem , 23 :e202200456 , 2022
Abstract :
PubMedSearch : Nachon_2022_Chembiochem_23_e202200456
PubMedID: 36193860
Gene_locus related to this paper: human-BCHE

Title : Pseudo-irreversible butyrylcholinesterase inhibitors: SAR, kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate warhead - Meden_2022_Chemrxiv__
Author(s) : Meden A , Knez D , Brazzolotto X , Modeste F , Perdih A , Pislar A , Zorman M , Denic M , Pajk S , Nachon F , Gobec S
Ref : Chemrxiv , : , 2022
Abstract :
PubMedSearch : Meden_2022_Chemrxiv__
PubMedID:
Gene_locus related to this paper: human-BCHE

Title : A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning - Da Silva_2022_J.Med.Chem_65_4649
Author(s) : Da Silva O , Probst N , Landry C , Hanak AS , Warnault P , Coisne C , Calas AG , Gosselet F , Courageux C , Gastellier AJ , Trancart M , Baati R , Dehouck MP , Jean L , Nachon F , Renard PY , Dias J
Ref : Journal of Medicinal Chemistry , 65 :4649 , 2022
Abstract :
PubMedSearch : Da Silva_2022_J.Med.Chem_65_4649
PubMedID: 35255209
Gene_locus related to this paper: human-ACHE

Title : Diisopropylfluorophosphate-induced status epilepticus drives complex glial cell phenotypes in adult male mice - Maupu_2021_Neurobiol.Dis__105276
Author(s) : Maupu C , Enderlin J , Igert A , Oger M , Auvin S , Hassan-Abdi R , Soussi-Yanicostas N , Brazzolotto X , Nachon F , Bo GD , Dupuis N
Ref : Neurobiol Dis , :105276 , 2021
Abstract :
PubMedSearch : Maupu_2021_Neurobiol.Dis__105276
PubMedID: 33529768

Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812
Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D
Ref : Journal of Medicinal Chemistry , 64 :812 , 2021
Abstract :
PubMedSearch : Viayna_2021_J.Med.Chem_64_812
PubMedID: 33356266
Gene_locus related to this paper: human-ACHE

Title : Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease - Rossi_2021_J.Med.Chem_64_4972
Author(s) : Rossi M , Freschi M , de Camargo Nascente L , Salerno A , de Melo Viana Teixeira S , Nachon F , Chantegreil F , Soukup O , Prchal L , Malaguti M , Bergamini C , Bartolini M , Angeloni C , Hrelia S , Soares Romeiro LA , Bolognesi ML
Ref : Journal of Medicinal Chemistry , 64 :4972 , 2021
Abstract :
PubMedSearch : Rossi_2021_J.Med.Chem_64_4972
PubMedID: 33829779
Gene_locus related to this paper: human-BCHE

Title : A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study - Bzdrenga_2021_Molecules_26_657
Author(s) : Bzdrenga J , Trenet E , Chantegreil F , Bernal K , Nachon F , Brazzolotto X
Ref : Molecules , 26 :657 , 2021
Abstract :
PubMedSearch : Bzdrenga_2021_Molecules_26_657
PubMedID: 33513869
Gene_locus related to this paper: 9bact-TtEst2

Title : Characterization of four BCHE mutations associated with prolonged effect of suxamethonium - Brazzolotto_2021_Pharmacogenomics.J_21_165
Author(s) : Brazzolotto X , Courcelle S , Sauvanet C , Guillon V , Igert A , Kononchik J , Nachon F , Ceppa F , Delacour H
Ref : Pharmacogenomics J , 21(2):165-173 : , 2021
Abstract :
PubMedSearch : Brazzolotto_2021_Pharmacogenomics.J_21_165
PubMedID: 33024248

Title : Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases - Chavarria_2021_Antioxidants.(Basel)_10_329
Author(s) : Chavarria D , Da Silva O , Benfeito S , Barreiro S , Garrido J , Cagide F , Soares P , Remiao F , Brazzolotto X , Nachon F , Oliveira PJ , Dias J , Borges F
Ref : Antioxidants (Basel) , 10 :329 , 2021
Abstract :
PubMedSearch : Chavarria_2021_Antioxidants.(Basel)_10_329
PubMedID: 33672269
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Development of versatile and potent monoquaternary reactivators of acetylcholinesterase - Gorecki_2021_Arch.Toxicol__
Author(s) : Gorecki L , Hepnarova V , Karasova JZ , Hrabinova M , Courageux C , Dias J , Kucera T , Kobrlova T , Muckova L , Prchal L , Malinak D , Jun D , Musilek K , Worek F , Nachon F , Soukup O , Korabecny J
Ref : Archives of Toxicology , : , 2021
Abstract :
PubMedSearch : Gorecki_2021_Arch.Toxicol__
PubMedID: 33517499

Title : An Antidote Screening System for Organophosphorus Poisoning Using Zebrafish Larvae - Dubrana_2021_ACS.Chem.Neurosci__
Author(s) : Dubrana LE , Knoll-Gellida A , Bourcier LM , Merce T , Pedemay S , Nachon F , Calas AG , Baati R , Soares M , Babin PJ
Ref : ACS Chem Neurosci , : , 2021
Abstract :
PubMedSearch : Dubrana_2021_ACS.Chem.Neurosci__
PubMedID: 34284583

Title : Impact of Sucrose as Osmolyte on Molecular Dynamics of Mouse Acetylcholinesterase - Lushchekina_2020_Biomolecules_10_
Author(s) : Lushchekina SV , Inidjel G , Martinez N , Masson P , Trovaslet-Leroy M , Nachon F , Koza MM , Seydel T , Peters J
Ref : Biomolecules , 10 : , 2020
Abstract :
PubMedSearch : Lushchekina_2020_Biomolecules_10_
PubMedID: 33322722

Title : Organophosphorus diisopropylfluorophosphate (DFP) intoxication in zebrafish larvae causes behavioral defects, neuronal hyperexcitation and neuronal death - Brenet_2020_Sci.Rep_10_19228
Author(s) : Brenet A , Somkhit J , Hassan-Abdi R , Yanicostas C , Romain C , Bar O , Igert A , Saurat D , Taudon N , Dal-Bo G , Nachon F , Dupuis N , Soussi-Yanicostas N
Ref : Sci Rep , 10 :19228 , 2020
Abstract :
PubMedSearch : Brenet_2020_Sci.Rep_10_19228
PubMedID: 33154418
Gene_locus related to this paper: danre-ACHE

Title : Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime - Calas_2020_Biomolecules_10_
Author(s) : Calas AG , Hanak AS , Jaffre N , Nervo A , Dias J , Rousseau C , Courageux C , Brazzolotto X , Villa P , Obrecht A , Goossens JF , Landry C , Hachani J , Gosselet F , Dehouck MP , Yerri J , Kliachyna M , Baati R , Nachon F
Ref : Biomolecules , 10 : , 2020
Abstract :
PubMedSearch : Calas_2020_Biomolecules_10_
PubMedID: 32512884

Title : Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors - Meden_2020_Eur.J.Med.Chem_208_112766
Author(s) : Meden A , Knez D , Malikowska-Racia N , Brazzolotto X , Nachon F , Svete J , Salat K , Groselj U , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 208 :112766 , 2020
Abstract :
PubMedSearch : Meden_2020_Eur.J.Med.Chem_208_112766
PubMedID: 32919297
Gene_locus related to this paper: human-BCHE

Title : N-alkylpiperidine carbamates as potential anti-Alzheimer's agents - Kosak_2020_Eur.J.Med.Chem_197_112282
Author(s) : Kosak U , Strasek N , Knez N , Jukic M , Zakelj S , Zahirovic A , Pislar A , Brazzolotto X , Nachon F , Kos J , Gobec S , Knez D
Ref : Eur Journal of Medicinal Chemistry , 197 :112282 , 2020
Abstract :
PubMedSearch : Kosak_2020_Eur.J.Med.Chem_197_112282
PubMedID: 32380361
Gene_locus related to this paper: human-BCHE

Title : Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes - Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498
Author(s) : Pajk S , Knez D , Kosak U , Zorovic M , Brazzolotto X , Coquelle N , Nachon F , Colletier JP , Zivin M , Stojan J , Gobec S
Ref : J Enzyme Inhib Med Chem , 35 :498 , 2020
Abstract :
PubMedSearch : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498
PubMedID: 31914836
Gene_locus related to this paper: human-BCHE

Title : Chemoselective Hydrogenation of 6-Alkynyl-3-fluoro-2-pyridinaldoximes: Access to First-in-Class 6-Alkyl-3-Fluoro-2-pyridinaldoxime Scaffolds as New Reactivators of Sarin-Inhibited Human Acetylcholinesterase with Increased Blood-Brain Barrier Permeability - Yerri_2020_Chemistry_26_15035
Author(s) : Yerri J , Dias J , Nimmakayala MR , Razafindrainibe F , Courageux C , Gastellier AJ , Jegoux J , Coisne C , Landry C , Gosselet F , Hachani J , Goossens JF , Dehouck MP , Nachon F , Baati R
Ref : Chemistry , 26 :15035 , 2020
Abstract :
PubMedSearch : Yerri_2020_Chemistry_26_15035
PubMedID: 32633095

Title : A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides - Nachon_2020_Molecules_25_1198
Author(s) : Nachon F , Rosenberry TL , Silman I , Sussman JL
Ref : Molecules , 25 :1198 , 2020
Abstract :
PubMedSearch : Nachon_2020_Molecules_25_1198
PubMedID: 32155891
Gene_locus related to this paper: drome-ACHE

Title : Characterization of organophosphate-induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure - Enderlin_2020_Epilepsia__
Author(s) : Enderlin J , Igert A , Auvin S , Nachon F , Dal Bo G , Dupuis N
Ref : Epilepsia , : , 2020
Abstract :
PubMedSearch : Enderlin_2020_Epilepsia__
PubMedID: 32359085

Title : X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates - Touvrey_2019_Toxicology_411_15
Author(s) : Touvrey C , Courageux C , Guillon V , Terreux R , Nachon F , Brazzolotto X
Ref : Toxicology , 411 :15 , 2019
Abstract :
PubMedSearch : Touvrey_2019_Toxicology_411_15
PubMedID: 30359675
Gene_locus related to this paper: human-CEL

Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491
Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K
Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019
Abstract :
PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491
PubMedID: 30851693
Gene_locus related to this paper: torca-ACHE

Title : Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase - Lalut_2019_Eur.J.Med.Chem_162_234
Author(s) : Lalut J , Santoni G , Karila D , Lecoutey C , Davis A , Nachon F , Silman I , Sussman JL , Weik M , Maurice T , Dallemagne P , Rochais C
Ref : Eur Journal of Medicinal Chemistry , 162 :234 , 2019
Abstract :
PubMedSearch : Lalut_2019_Eur.J.Med.Chem_162_234
PubMedID: 30447434
Gene_locus related to this paper: torca-ACHE

Title : Respiratory failure triggered by cholinesterase inhibitors may involve activation of a reflex sensory pathway by acetylcholine spillover - Nervo_2019_Toxicology_424_152232
Author(s) : Nervo A , Calas AG , Nachon F , Krejci E
Ref : Toxicology , 424 :152232 , 2019
Abstract :
PubMedSearch : Nervo_2019_Toxicology_424_152232
PubMedID: 31175885

Title : Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease - Meden_2019_Chem.Commun.(Camb)_55_3765
Author(s) : Meden A , Knez D , Jukic M , Brazzolotto X , Grsic M , Pislar A , Zahirovic A , Kos J , Nachon F , Svete J , Gobec S , Groselj U
Ref : Chem Commun (Camb) , 55 :3765 , 2019
Abstract :
PubMedSearch : Meden_2019_Chem.Commun.(Camb)_55_3765
PubMedID: 30864579
Gene_locus related to this paper: human-BCHE

Title : New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease - Zueva_2019_Neuropharmacol_155_131
Author(s) : Zueva IV , Dias J , Lushchekina SV , Semenov VE , Mukhamedyarov MA , Pashirova TN , Babaev VM , Nachon F , Petrova N , Nurullin LF , Zakharova LY , Ilyin VI , Masson P , Petrov KA
Ref : Neuropharmacology , 155 :131 , 2019
Abstract :
PubMedSearch : Zueva_2019_Neuropharmacol_155_131
PubMedID: 31132435
Gene_locus related to this paper: human-ACHE

Title : Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents - Santoni_2018_J.Med.Chem_61_7630
Author(s) : Santoni G , de Sousa J , De la Mora E , Dias J , Jean L , Sussman JL , Silman I , Renard PY , Brown RCD , Weik M , Baati R , Nachon F
Ref : Journal of Medicinal Chemistry , 61 :7630 , 2018
Abstract :
PubMedSearch : Santoni_2018_J.Med.Chem_61_7630
PubMedID: 30125110
Gene_locus related to this paper: torca-ACHE

Title : Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration - Zorbaz_2018_Chemistry_24_9675
Author(s) : Zorbaz T , Braiki A , Marakovic N , Renou J , De la Mora E , Macek Hrvat N , Katalinic M , Silman I , Sussman JL , Mercey G , Gomez C , Mougeot R , Perez B , Baati R , Nachon F , Weik M , Jean L , Kovarik Z , Renard PY
Ref : Chemistry , 24 :9675 , 2018
Abstract :
PubMedSearch : Zorbaz_2018_Chemistry_24_9675
PubMedID: 29672968
Gene_locus related to this paper: torca-ACHE

Title : Purification of recombinant human butyrylcholinesterase on Hupresin(R) - Lockridge_2018_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1102-1103_109
Author(s) : Lockridge O , David E , Schopfer LM , Masson P , Brazzolotto X , Nachon F
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1102-1103 :109 , 2018
Abstract :
PubMedSearch : Lockridge_2018_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1102-1103_109
PubMedID: 30384187

Title : Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities - Knez_2018_Eur.J.Med.Chem_156_598
Author(s) : Knez D , Coquelle N , Pislar A , Zakelj S , Jukic M , Sova M , Mravljak J , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 156 :598 , 2018
Abstract :
PubMedSearch : Knez_2018_Eur.J.Med.Chem_156_598
PubMedID: 30031971
Gene_locus related to this paper: human-BCHE

Title : The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity - Kosak_2018_J.Med.Chem_61_119
Author(s) : Kosak U , Brus B , Knez D , Zakelj S , Trontelj J , Pislar A , Sink R , Jukic M , Zivin M , Podkowa A , Nachon F , Brazzolotto X , Stojan J , Kos J , Coquelle N , Salat K , Colletier JP , Gobec S
Ref : Journal of Medicinal Chemistry , 61 :119 , 2018
Abstract :
PubMedSearch : Kosak_2018_J.Med.Chem_61_119
PubMedID: 29227101
Gene_locus related to this paper: human-BCHE

Title : On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM\/MM Approach - Driant_2017_Chembiochem_18_666
Author(s) : Driant T , Nachon F , Ollivier C , Renard PY , Derat E
Ref : Chembiochem , 18 :666 , 2017
Abstract :
PubMedSearch : Driant_2017_Chembiochem_18_666
PubMedID: 28106328

Title : Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning - Masson_2017_J.Neurochem_142 Suppl 2_26
Author(s) : Masson P , Nachon F
Ref : Journal of Neurochemistry , 142 Suppl 2 :26 , 2017
Abstract :
PubMedSearch : Masson_2017_J.Neurochem_142 Suppl 2_26
PubMedID: 28542985

Title : An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice - Calas_2017_Chem.Biol.Interact_267_11
Author(s) : Calas AG , Dias J , Rousseau C , Arboleas M , Touvrey-Loiodice M , Mercey G , Jean L , Renard PY , Nachon F
Ref : Chemico-Biological Interactions , 267 :11 , 2017
Abstract :
PubMedSearch : Calas_2017_Chem.Biol.Interact_267_11
PubMedID: 26972668

Title : Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase - de Koning_2017_J.Med.Chem_60_9376
Author(s) : De Koning MC , Joosen MJ , Worek F , Nachon F , van Grol M , Klaassen SD , Alkema DPW , Wille T , de Bruijn HM
Ref : Journal of Medicinal Chemistry , 60 :9376 , 2017
Abstract :
PubMedSearch : de Koning_2017_J.Med.Chem_60_9376
PubMedID: 29091431

Title : Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study - Rosenberry_2017_Molecules_22_
Author(s) : Rosenberry TL , Brazzolotto X , Macdonald IR , Wandhammer M , Trovaslet-Leroy M , Darvesh S , Nachon F
Ref : Molecules , 22 : , 2017
Abstract :
PubMedSearch : Rosenberry_2017_Molecules_22_
PubMedID: 29186056
Gene_locus related to this paper: human-BCHE

Title : N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents - Kosak_2017_Bioorg.Med.Chem_25_633
Author(s) : Kosak U , Knez D , Coquelle N , Brus B , Pislar A , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S
Ref : Bioorganic & Medicinal Chemistry , 25 :633 , 2017
Abstract :
PubMedSearch : Kosak_2017_Bioorg.Med.Chem_25_633
PubMedID: 27908752
Gene_locus related to this paper: human-BCHE

Title : Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development - Brazzolotto_2017_Molecules_22_
Author(s) : Brazzolotto X , Igert A , Guillon V , Santoni G , Nachon F
Ref : Molecules , 22 : , 2017
Abstract :
PubMedSearch : Brazzolotto_2017_Molecules_22_
PubMedID: 29077024
Gene_locus related to this paper: human-BCHE

Title : Dynamics of human acetylcholinesterase bound to non-covalent and covalent inhibitors shedding light on changes to the water network structure - Peters_2016_Phys.Chem.Chem.Phys_18_12992
Author(s) : Peters J , Martinez N , Trovaslet M , Scannapieco K , Koza MM , Masson P , Nachon F
Ref : Phys Chem Chem Phys , 18 :12992 , 2016
Abstract :
PubMedSearch : Peters_2016_Phys.Chem.Chem.Phys_18_12992
PubMedID: 27109895

Title : Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment - Kharlamova_2016_Biochem.J_473_1225
Author(s) : Kharlamova AD , Lushchekina SV , Petrov KA , Kots ED , Nachon F , Villard-Wandhammer M , Zueva IV , Krejci E , Reznik VS , Zobov VV , Nikolsky EE , Masson P
Ref : Biochemical Journal , 473 :1225 , 2016
Abstract :
PubMedSearch : Kharlamova_2016_Biochem.J_473_1225
PubMedID: 26929400
Gene_locus related to this paper: mouse-ACHE

Title : Development of an in-vivo active reversible butyrylcholinesterase inhibitor - Kosak_2016_Sci.Rep_6_39495
Author(s) : Kosak U , Brus B , Knez D , Sink R , Zakelj S , Trontelj J , Pislar A , Slenc J , Gobec M , Zivin M , Tratnjek L , Perse M , Salat K , Podkowa A , Filipek B , Nachon F , Brazzolotto X , Wieckowska A , Malawska B , Stojan J , Rascan IM , Kos J , Coquelle N , Colletier JP , Gobec S
Ref : Sci Rep , 6 :39495 , 2016
Abstract :
PubMedSearch : Kosak_2016_Sci.Rep_6_39495
PubMedID: 28000737
Gene_locus related to this paper: human-BCHE

Title : Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening - Dighe_2016_J.Med.Chem_59_7683
Author(s) : Dighe SN , Deora GS , De la Mora E , Nachon F , Chan S , Parat MO , Brazzolotto X , Ross BP
Ref : Journal of Medicinal Chemistry , 59 :7683 , 2016
Abstract :
PubMedSearch : Dighe_2016_J.Med.Chem_59_7683
PubMedID: 27405689
Gene_locus related to this paper: human-BCHE

Title : Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases - Torrent_2015_Acta.Neuropathol.Commun_3_18
Author(s) : Torrent J , Vilchez-Acosta A , Munoz-Torrero D , Trovaslet M , Nachon F , Chatonnet A , Grznarova K , Acquatella-Tran Van Ba I , Le Goffic R , Herzog L , Beringue V , Rezaei H
Ref : Acta Neuropathologica Commun , 3 :18 , 2015
Abstract :
PubMedSearch : Torrent_2015_Acta.Neuropathol.Commun_3_18
PubMedID: 25853328

Title : Pressure-induced molten globule state of human acetylcholinesterase: structural and dynamical changes monitored by neutron scattering - Marion_2015_Phys.Chem.Chem.Phys_17_3157
Author(s) : Marion J , Trovaslet M , Martinez N , Masson P , Schweins R , Nachon F , Trapp M , Peters J
Ref : Phys Chem Chem Phys , 17 :3157 , 2015
Abstract :
PubMedSearch : Marion_2015_Phys.Chem.Chem.Phys_17_3157
PubMedID: 25515378

Title : Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases - Renou_2014_Chem.Commun.(Camb)_50_3947
Author(s) : Renou J , Loiodice M , Arboleas M , Baati R , Jean L , Nachon F , Renard PY
Ref : Chem Commun (Camb) , 50 :3947 , 2014
Abstract :
PubMedSearch : Renou_2014_Chem.Commun.(Camb)_50_3947
PubMedID: 24599312

Title : Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds - Trapp_2014_J.R.Soc.Interface_11_
Author(s) : Trapp M , Tehei M , Trovaslet M , Nachon F , Martinez N , Koza MM , Weik M , Masson P , Peters J
Ref : J R Soc Interface , 11 : , 2014
Abstract :
PubMedSearch : Trapp_2014_J.R.Soc.Interface_11_
PubMedID: 24872501

Title : Reaction site-driven regioselective synthesis of AChE inhibitors - Oueis_2014_Org.Biomol.Chem_12_156
Author(s) : Oueis E , Santoni G , Ronco C , Syzgantseva O , Tognetti V , Joubert L , Romieu A , Weik M , Jean L , Sabot C , Nachon F , Renard PY
Ref : Org Biomol Chem , 12 :156 , 2014
Abstract :
PubMedSearch : Oueis_2014_Org.Biomol.Chem_12_156
PubMedID: 24216754

Title : First enzymatic hydrolysis\/thio-Michael addition cascade route to synthesis of AChE inhibitors - Oueis_2014_Chem.Commun.(Camb)_50_2043
Author(s) : Oueis E , Nachon F , Sabot C , Renard PY
Ref : Chem Commun (Camb) , 50 :2043 , 2014
Abstract :
PubMedSearch : Oueis_2014_Chem.Commun.(Camb)_50_2043
PubMedID: 24418813

Title : Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase - Kliachyna_2014_Eur.J.Med.Chem_78C_455
Author(s) : Kliachyna M , Santoni G , Nussbaum V , Renou J , Sanson B , Colletier JP , Arboleas M , Loiodice M , Weik M , Jean L , Renard PY , Nachon F , Baati R
Ref : Eur Journal of Medicinal Chemistry , 78C :455 , 2014
Abstract :
PubMedSearch : Kliachyna_2014_Eur.J.Med.Chem_78C_455
PubMedID: 24704618

Title : PHOS-Select Iron Affinity Beads Enrich Peptides for the Detection of Organophosphorus Adducts on Albumin - Jiang_2013_Chem.Res.Toxicol_26_1917
Author(s) : Jiang W , Dubrovskii YA , Podolskaya EP , Murashko EA , Babakov VN , Nachon F , Masson P , Schopfer LM , Lockridge O
Ref : Chemical Research in Toxicology , 26 :1917 , 2013
Abstract :
PubMedSearch : Jiang_2013_Chem.Res.Toxicol_26_1917
PubMedID: 24187955

Title : Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond - Jiang_2013_Toxicol.Sci_132_390
Author(s) : Jiang W , Cashman JR , Nachon F , Masson P , Schopfer LM , Lockridge O
Ref : Toxicol Sci , 132 :390 , 2013
Abstract :
PubMedSearch : Jiang_2013_Toxicol.Sci_132_390
PubMedID: 23345579

Title : Relation between dynamics, activity and thermal stability within the cholinesterase family - Trovaslet_2013_Chem.Biol.Interact_203_14
Author(s) : Trovaslet M , Trapp M , Weik M , Nachon F , Masson P , Tehei M , Peters J
Ref : Chemico-Biological Interactions , 203 :14 , 2013
Abstract :
PubMedSearch : Trovaslet_2013_Chem.Biol.Interact_203_14
PubMedID: 22940283

Title : Progress in the development of enzyme-based nerve agent bioscavengers - Nachon_2013_Chem.Biol.Interact_206_536
Author(s) : Nachon F , Brazzolotto X , Trovaslet M , Masson P
Ref : Chemico-Biological Interactions , 206 :536 , 2013
Abstract :
PubMedSearch : Nachon_2013_Chem.Biol.Interact_206_536
PubMedID: 23811386

Title : Polyclonal antibody to soman-tyrosine - Li_2013_Chem.Res.Toxicol_26_584
Author(s) : Li B , Duysen EG , Froment MT , Masson P , Nachon F , Jiang W , Schopfer LM , Thiele GM , Klassen LW , Cashman JR , Williams GR , Lockridge O
Ref : Chemical Research in Toxicology , 26 :584 , 2013
Abstract :
PubMedSearch : Li_2013_Chem.Res.Toxicol_26_584
PubMedID: 23469927

Title : Matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase - Jiang_2013_Anal.Biochem_439_132
Author(s) : Jiang W , Murashko EA , Dubrovskii YA , Podolskaya EP , Babakov VN , Mikler J , Nachon F , Masson P , Schopfer LM , Lockridge O
Ref : Analytical Biochemistry , 439 :132 , 2013
Abstract :
PubMedSearch : Jiang_2013_Anal.Biochem_439_132
PubMedID: 23624322

Title : A step toward the reactivation of aged cholinesterases - Crystal structure of ligands binding to aged human butyrylcholinesterase - Wandhammer_2013_Chem.Biol.Interact_203_19
Author(s) : Wandhammer M , De Koning MC , van Grol M , Loiodice M , Saurel L , Noort D , Goeldner M , Nachon F
Ref : Chemico-Biological Interactions , 203 :19 , 2013
Abstract :
PubMedSearch : Wandhammer_2013_Chem.Biol.Interact_203_19
PubMedID: 22922115
Gene_locus related to this paper: human-BCHE

Title : Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents - Renou_2013_Chem.Biol.Interact_203_81
Author(s) : Renou J , Mercey G , Verdelet T , Paunescu E , Gillon E , Arboleas M , Loiodice M , Kliachyna M , Baati R , Nachon F , Jean L , Renard PY
Ref : Chemico-Biological Interactions , 203 :81 , 2013
Abstract :
PubMedSearch : Renou_2013_Chem.Biol.Interact_203_81
PubMedID: 23111374

Title : Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase - Nachon_2013_Biochem.J_453_393
Author(s) : Nachon F , Carletti E , Ronco C , Trovaslet M , Nicolet Y , Jean L , Renard PY
Ref : Biochemical Journal , 453 :393 , 2013
Abstract :
PubMedSearch : Nachon_2013_Biochem.J_453_393
PubMedID: 23679855
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry - Carletti_2013_Chem.Res.Toxicol_26_280
Author(s) : Carletti E , Colletier JP , Schopfer LM , Santoni G , Masson P , Lockridge O , Nachon F , Weik M
Ref : Chemical Research in Toxicology , 26 :280 , 2013
Abstract :
PubMedSearch : Carletti_2013_Chem.Res.Toxicol_26_280
PubMedID: 23339663
Gene_locus related to this paper: human-BCHE , mouse-ACHE

Title : Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran - Duysen_2012_Chem.Biol.Interact_195_189
Author(s) : Duysen EG , Cashman JR , Schopfer LM , Nachon F , Masson P , Lockridge O
Ref : Chemico-Biological Interactions , 195 :189 , 2012
Abstract :
PubMedSearch : Duysen_2012_Chem.Biol.Interact_195_189
PubMedID: 22209767

Title : Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase - Mercey_2012_J.Med.Chem_55_10791
Author(s) : Mercey G , Renou J , Verdelet T , Kliachyna M , Baati R , Gillon E , Arboleas M , Loiodice M , Nachon F , Jean L , Renard PY
Ref : Journal of Medicinal Chemistry , 55 :10791 , 2012
Abstract :
PubMedSearch : Mercey_2012_J.Med.Chem_55_10791
PubMedID: 23148598

Title : Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography - Ronco_2012_ChemMedChem_7_400
Author(s) : Ronco C , Carletti E , Colletier JP , Weik M , Nachon F , Jean L , Renard PY
Ref : ChemMedChem , 7 :400 , 2012
Abstract :
PubMedSearch : Ronco_2012_ChemMedChem_7_400
PubMedID: 22052791
Gene_locus related to this paper: mouse-ACHE

Title : Activity and molecular dynamics relationship within the family of human cholinesterases - Peters_2012_Phys.Chem.Chem.Phys_14_6764
Author(s) : Peters J , Trovaslet M , Trapp M , Nachon F , Hill F , Royer E , Gabel F , van Eijck L , Masson P , Tehei M
Ref : Phys Chem Chem Phys , 14 :6764 , 2012
Abstract :
PubMedSearch : Peters_2012_Phys.Chem.Chem.Phys_14_6764
PubMedID: 22395795

Title : Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents - Mercey_2012_Acc.Chem.Res_45_756
Author(s) : Mercey G , Verdelet T , Renou J , Kliachyna M , Baati R , Nachon F , Jean L , Renard PY
Ref : Acc Chem Res , 45 :756 , 2012
Abstract :
PubMedSearch : Mercey_2012_Acc.Chem.Res_45_756
PubMedID: 22360473

Title : Energy landscapes of human acetylcholinesterase and its huperzine a-inhibited counterpart - Trapp_2012_J.Phys.Chem.B_116_14744
Author(s) : Trapp M , Trovaslet M , Nachon F , Koza MM , van Eijck L , Hill F , Weik M , Masson P , Tehei M , Peters J
Ref : J Phys Chem B , 116 :14744 , 2012
Abstract :
PubMedSearch : Trapp_2012_J.Phys.Chem.B_116_14744
PubMedID: 23186408

Title : Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure - Brazzolotto_2012_Febs.J_279_2905
Author(s) : Brazzolotto X , Wandhammer M , Ronco C , Trovaslet M , Jean L , Lockridge O , Renard PY , Nachon F
Ref : Febs J , 279 :2905 , 2012
Abstract :
PubMedSearch : Brazzolotto_2012_Febs.J_279_2905
PubMedID: 22726956
Gene_locus related to this paper: human-BCHE

Title : Evolution of Acetylcholinesterase and Butyrylcholinesterase in the Vertebrates: An Atypical Butyrylcholinesterase from the Medaka Oryzias latipes - Pezzementi_2011_PLoS.ONE_6_e17396
Author(s) : Pezzementi L , Nachon F , Chatonnet A
Ref : PLoS ONE , 6 :e17396 , 2011
Abstract :
PubMedSearch : Pezzementi_2011_PLoS.ONE_6_e17396
PubMedID: 21364766
Gene_locus related to this paper: oryla-BCHE

Title : Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics - Smirnov_2011_Proc.Natl.Acad.Sci.U.S.A_108_15954
Author(s) : Smirnov IV , Carletti E , Kurkova I , Nachon F , Nicolet Y , Mitkevich VA , Debat H , Avalle B , Belogurov AA, Jr. , Kuznetsov N , Reshetnyak A , Masson P , Tonevitsky AG , Ponomarenko NA , Makarov AA , Friboulet A , Tramontano A , Gabibov AG
Ref : Proc Natl Acad Sci U S A , 108 :15954 , 2011
Abstract :
PubMedSearch : Smirnov_2011_Proc.Natl.Acad.Sci.U.S.A_108_15954
PubMedID: 21896761

Title : First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase - Mercey_2011_Chem.Commun.(Camb)_47_5295
Author(s) : Mercey G , Verdelet T , Saint-Andre G , Gillon E , Wagner A , Baati R , Jean L , Nachon F , Renard PY
Ref : Chem Commun (Camb) , 47 :5295 , 2011
Abstract :
PubMedSearch : Mercey_2011_Chem.Commun.(Camb)_47_5295
PubMedID: 21451868

Title : The kinetic study of the inhibition of human cholinesterases by demeton-S-methyl shows that cholinesterase-based titration methods are not suitable for this organophosphate - Bazire_2011_Toxicol.In.Vitro_25_754
Author(s) : Bazire A , Gillon E , Lockridge O , Vallet V , Nachon F
Ref : Toxicol In Vitro , 25 :754 , 2011
Abstract :
PubMedSearch : Bazire_2011_Toxicol.In.Vitro_25_754
PubMedID: 21238577

Title : New huprine derivatives functionalized at position 9 as highly potent acetylcholinesterase inhibitors - Ronco_2011_ChemMedChem_6_876
Author(s) : Ronco C , Foucault R , Gillon E , Bohn P , Nachon F , Jean L , Renard PY
Ref : ChemMedChem , 6 :876 , 2011
Abstract :
PubMedSearch : Ronco_2011_ChemMedChem_6_876
PubMedID: 21344648

Title : Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents - Trovaslet-Leroy_2011_Toxicol.Lett_206_14
Author(s) : Trovaslet-Leroy M , Musilova L , Renault F , Brazzolotto X , Misik J , Novotny L , Froment MT , Gillon E , Loiodice M , Verdier L , Masson P , Rochu D , Jun D , Nachon F
Ref : Toxicol Lett , 206 :14 , 2011
Abstract :
PubMedSearch : Trovaslet-Leroy_2011_Toxicol.Lett_206_14
PubMedID: 21683774

Title : Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment - Musilek_2011_Eur.J.Med.Chem_46_811
Author(s) : Musilek K , Komloova M , Holas O , Hrabinova M , Pohanka M , Dohnal V , Nachon F , Dolezal M , Kuca K
Ref : Eur Journal of Medicinal Chemistry , 46 :811 , 2011
Abstract :
PubMedSearch : Musilek_2011_Eur.J.Med.Chem_46_811
PubMedID: 21236521

Title : X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger - Nachon_2011_Biochem.J_434_73
Author(s) : Nachon F , Carletti E , Wandhammer M , Nicolet Y , Schopfer LM , Masson P , Lockridge O
Ref : Biochemical Journal , 434 :73 , 2011
Abstract :
PubMedSearch : Nachon_2011_Biochem.J_434_73
PubMedID: 21091433
Gene_locus related to this paper: human-BCHE

Title : Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis - Carletti_2011_Chem.Res.Toxicol_24_797
Author(s) : Carletti E , Schopfer LM , Colletier JP , Froment MT , Nachon F , Weik M , Lockridge O , Masson P
Ref : Chemical Research in Toxicology , 24 :797 , 2011
Abstract :
PubMedSearch : Carletti_2011_Chem.Res.Toxicol_24_797
PubMedID: 21438623
Gene_locus related to this paper: human-BCHE

Title : Structural study of the complex stereoselectivity of human butyrylcholinesterase for the neurotoxic V-agents - Wandhammer_2011_J.Biol.Chem_286_16783
Author(s) : Wandhammer M , Carletti E , van der Schans M , Gillon E , Nicolet Y , Masson P , Goeldner M , Noort D , Nachon F
Ref : Journal of Biological Chemistry , 286 :16783 , 2011
Abstract :
PubMedSearch : Wandhammer_2011_J.Biol.Chem_286_16783
PubMedID: 21454498
Gene_locus related to this paper: human-BCHE

Title : Exposure to tri-o-cresyl phosphate detected in jet airplane passengers - Liyasova_2011_Toxicol.Appl.Pharmacol_256_337
Author(s) : Liyasova M , Li B , Schopfer LM , Nachon F , Masson P , Furlong CE , Lockridge O
Ref : Toxicol Appl Pharmacol , 256 :337 , 2011
Abstract :
PubMedSearch : Liyasova_2011_Toxicol.Appl.Pharmacol_256_337
PubMedID: 21723309

Title : Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation - Carletti_2010_J.Med.Chem_53_4002
Author(s) : Carletti E , Colletier JP , Dupeux F , Trovaslet M , Masson P , Nachon F
Ref : Journal of Medicinal Chemistry , 53 :4002 , 2010
Abstract :
PubMedSearch : Carletti_2010_J.Med.Chem_53_4002
PubMedID: 20408548
Gene_locus related to this paper: human-ACHE

Title : Aging mechanism of butyrylcholinesterase inhibited by an N-methyl analogue of tabun: implications of the trigonal-bipyramidal transition state rearrangement for the phosphylation or reactivation of cholinesterases - Nachon_2010_Chem.Biol.Interact_187_44
Author(s) : Nachon F , Carletti E , Worek F , Masson P
Ref : Chemico-Biological Interactions , 187 :44 , 2010
Abstract :
PubMedSearch : Nachon_2010_Chem.Biol.Interact_187_44
PubMedID: 20381476

Title : Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates - Schopfer_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1297
Author(s) : Schopfer LM , Grigoryan H , Li B , Nachon F , Masson P , Lockridge O
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 878 :1297 , 2010
Abstract :
PubMedSearch : Schopfer_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1297
PubMedID: 19762289

Title : Accumulation of tetrahedral intermediates in cholinesterase catalysis: a secondary isotope effect study - Tormos_2010_J.Am.Chem.Soc_132_17751
Author(s) : Tormos JR , Wiley KL , Wang Y , Fournier D , Masson P , Nachon F , Quinn DM
Ref : Journal of the American Chemical Society , 132 :17751 , 2010
Abstract :
PubMedSearch : Tormos_2010_J.Am.Chem.Soc_132_17751
PubMedID: 21105647

Title : Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos - Li_2010_Toxicol.Sci_116_23
Author(s) : Li B , Ricordel I , Schopfer LM , Baud F , Megarbane B , Nachon F , Masson P , Lockridge O
Ref : Toxicol Sci , 116 :23 , 2010
Abstract :
PubMedSearch : Li_2010_Toxicol.Sci_116_23
PubMedID: 20395308

Title : Structural approach to the aging of phosphylated cholinesterases - Masson_2010_Chem.Biol.Interact_187_157
Author(s) : Masson P , Nachon F , Lockridge O
Ref : Chemico-Biological Interactions , 187 :157 , 2010
Abstract :
PubMedSearch : Masson_2010_Chem.Biol.Interact_187_157
PubMedID: 20338153

Title : Application of laccase-mediator system (LMS) for the degradation of organophosphorus compounds - Trovaslet-Leroy_2010_Chem.Biol.Interact_187_393
Author(s) : Trovaslet-Leroy M , Jolivalt C , Froment MT , Brasme B , Lefebvre B , Daveloose D , Nachon F , Masson P
Ref : Chemico-Biological Interactions , 187 :393 , 2010
Abstract :
PubMedSearch : Trovaslet-Leroy_2010_Chem.Biol.Interact_187_393
PubMedID: 20149786

Title : Preparation and characterization of methoxy polyethylene glycol-conjugated phosphotriesterase as a potential catalytic bioscavenger against organophosphate poisoning - Jun_2010_Chem.Biol.Interact_187_380
Author(s) : Jun D , Musilova L , Link M , Loiodice M , Nachon F , Rochu D , Renault F , Masson P
Ref : Chemico-Biological Interactions , 187 :380 , 2010
Abstract :
PubMedSearch : Jun_2010_Chem.Biol.Interact_187_380
PubMedID: 20230809

Title : Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications - Musilek_2010_Bioorg.Med.Chem.Lett_20_1763
Author(s) : Musilek K , Komloova M , Zavadova V , Holas O , Hrabinova M , Pohanka M , Dohnal V , Nachon F , Dolezal M , Kuca K , Jung YS
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1763 , 2010
Abstract :
PubMedSearch : Musilek_2010_Bioorg.Med.Chem.Lett_20_1763
PubMedID: 20138518

Title : Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment - Korabecny_2010_Molecules_15_8804
Author(s) : Korabecny J , Musilek K , Holas O , Nepovimova E , Jun D , Zemek F , Opletalova V , Patocka J , Dohnal V , Nachon F , Hroudova J , Fisar Z , Kuca K
Ref : Molecules , 15 :8804 , 2010
Abstract :
PubMedSearch : Korabecny_2010_Molecules_15_8804
PubMedID: 21127466

Title : Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. - Carletti_2009_Biochem.J_421_97
Author(s) : Carletti E , Aurbek N , Gillon E , Loiodice M , Nicolet Y , Fontecilla-Camps JC , Masson P , Thiermann H , Nachon F , Worek F
Ref : Biochemical Journal , 421 :97 , 2009
Abstract :
PubMedSearch : Carletti_2009_Biochem.J_421_97
PubMedID: 19368529
Gene_locus related to this paper: human-BCHE

Title : Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine - Grigoryan_2009_Chem.Biol.Interact_180_492
Author(s) : Grigoryan H , Li B , Anderson EK , Xue W , Nachon F , Lockridge O , Schopfer LM
Ref : Chemico-Biological Interactions , 180 :492 , 2009
Abstract :
PubMedSearch : Grigoryan_2009_Chem.Biol.Interact_180_492
PubMedID: 19539807

Title : Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime - Sanson_2009_J.Med.Chem_52_7593
Author(s) : Sanson B , Nachon F , Colletier JP , Froment MT , Toker L , Greenblatt HM , Sussman JL , Ashani Y , Masson P , Silman I , Weik M
Ref : Journal of Medicinal Chemistry , 52 :7593 , 2009
Abstract :
PubMedSearch : Sanson_2009_J.Med.Chem_52_7593
PubMedID: 19642642
Gene_locus related to this paper: torca-ACHE

Title : Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase - Gilley_2009_Chem.Res.Toxicol_22_1680
Author(s) : Gilley C , MacDonald M , Nachon F , Schopfer LM , Zhang J , Cashman JR , Lockridge O
Ref : Chemical Research in Toxicology , 22 :1680 , 2009
Abstract :
PubMedSearch : Gilley_2009_Chem.Res.Toxicol_22_1680
PubMedID: 19715348

Title : Structure, activities and biomedical applications of human butyrylcholinesterase - Masson_2009_Protein.Pept.Lett_16_1215
Author(s) : Masson P , Carletti E , Nachon F
Ref : Protein Pept Lett , 16 :1215 , 2009
Abstract :
PubMedSearch : Masson_2009_Protein.Pept.Lett_16_1215
PubMedID: 19508180

Title : Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors - Ronco_2009_Bioorg.Med.Chem_17_4523
Author(s) : Ronco C , Sorin G , Nachon F , Foucault R , Jean L , Romieu A , Renard PY
Ref : Bioorganic & Medicinal Chemistry , 17 :4523 , 2009
Abstract :
PubMedSearch : Ronco_2009_Bioorg.Med.Chem_17_4523
PubMedID: 19473849

Title : Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel - Nachon_2008_FEBS.J_275_2659
Author(s) : Nachon F , Stojan J , Fournier D
Ref : Febs J , 275 :2659 , 2008
Abstract :
PubMedSearch : Nachon_2008_FEBS.J_275_2659
PubMedID: 18422651

Title : Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation - Carletti_2008_J.Am.Chem.Soc_130_16011
Author(s) : Carletti E , Li H , Li B , Ekstrom F , Nicolet Y , Loiodice M , Gillon E , Froment MT , Lockridge O , Schopfer LM , Masson P , Nachon F
Ref : Journal of the American Chemical Society , 130 :16011 , 2008
Abstract :
PubMedSearch : Carletti_2008_J.Am.Chem.Soc_130_16011
PubMedID: 18975951
Gene_locus related to this paper: human-BCHE , mouse-ACHE

Title : Binding and hydrolysis of soman by human serum albumin - Li_2008_Chem.Res.Toxicol_21_421
Author(s) : Li B , Nachon F , Froment MT , Verdier L , Debouzy JC , Brasme B , Gillon E , Schopfer LM , Lockridge O , Masson P
Ref : Chemical Research in Toxicology , 21 :421 , 2008
Abstract :
PubMedSearch : Li_2008_Chem.Res.Toxicol_21_421
PubMedID: 18163544

Title : Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin - Ding_2008_Chem.Res.Toxicol_21_1787
Author(s) : Ding SJ , Carr J , Carlson JE , Tong L , Xue W , Li Y , Schopfer LM , Li B , Nachon F , Asojo OA , Thompson CM , Hinrichs SH , Masson P , Lockridge O
Ref : Chemical Research in Toxicology , 21 :1787 , 2008
Abstract :
PubMedSearch : Ding_2008_Chem.Res.Toxicol_21_1787
PubMedID: 18707141

Title : Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters - Masson_2008_FEBS.J_275_2617
Author(s) : Masson P , Froment MT , Gillon E , Nachon F , Lockridge O , Schopfer LM
Ref : Febs J , 275 :2617 , 2008
Abstract :
PubMedSearch : Masson_2008_FEBS.J_275_2617
PubMedID: 18422653

Title : Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population - Mikami_2008_Pharmacogenet.Genomics_18_213
Author(s) : Mikami LR , Wieseler S , de Souza RLR , Schopfer LM , Nachon F , Lockridge O , Chautard-Freire-Maia EA
Ref : Pharmacogenet Genomics , 18 :213 , 2008
Abstract :
PubMedSearch : Mikami_2008_Pharmacogenet.Genomics_18_213
PubMedID: 18300943

Title : A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters - Masson_2008_Chem.Biol.Interact_175_273
Author(s) : Masson P , Nachon F , Broomfield CA , Lenz DE , Verdier L , Schopfer LM , Lockridge O
Ref : Chemico-Biological Interactions , 175 :273 , 2008
Abstract :
PubMedSearch : Masson_2008_Chem.Biol.Interact_175_273
PubMedID: 18508040

Title : Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase - Masson_2007_Biochim.Biophys.Acta_1774_16
Author(s) : Masson P , Froment MT , Gillon E , Nachon F , Lockridge O , Schopfer LM
Ref : Biochimica & Biophysica Acta , 1774 :16 , 2007
Abstract :
PubMedSearch : Masson_2007_Biochim.Biophys.Acta_1774_16
PubMedID: 17182295

Title : Kinetic analysis of butyrylcholinesterase-catalyzed hydrolysis of acetanilides - Masson_2007_Biochim.Biophys.Acta_1774_1139
Author(s) : Masson P , Froment MT , Gillon E , Nachon F , Darvesh S , Schopfer LM
Ref : Biochimica & Biophysica Acta , 1774 :1139 , 2007
Abstract :
PubMedSearch : Masson_2007_Biochim.Biophys.Acta_1774_1139
PubMedID: 17690023

Title : Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry - Li_2007_Toxicol.Sci_100_136
Author(s) : Li H , Schopfer LM , Nachon F , Froment MT , Masson P , Lockridge O
Ref : Toxicol Sci , 100 :136 , 2007
Abstract :
PubMedSearch : Li_2007_Toxicol.Sci_100_136
PubMedID: 17698511

Title : Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography - Colletier_2007_Acta.Crystallogr.D.Biol.Crystallogr_63_1115
Author(s) : Colletier JP , Royant A , Specht A , Sanson B , Nachon F , Masson P , Zaccai G , Sussman JL , Goeldner M , Silman I , Bourgeois D , Weik M
Ref : Acta Crystallographica D Biol Crystallogr , 63 :1115 , 2007
Abstract :
PubMedSearch : Colletier_2007_Acta.Crystallogr.D.Biol.Crystallogr_63_1115
PubMedID: 18007027
Gene_locus related to this paper: torca-ACHE

Title : Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters - Poyot_2006_Biochim.Biophys.Acta_1764_1470
Author(s) : Poyot T , Nachon F , Froment MT , Loiodice M , Wieseler S , Schopfer LM , Lockridge O , Masson P
Ref : Biochimica & Biophysica Acta , 1764 :1470 , 2006
Abstract :
PubMedSearch : Poyot_2006_Biochim.Biophys.Acta_1764_1470
PubMedID: 16962835

Title : Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor - Colletier_2006_J.Am.Chem.Soc_128_4526
Author(s) : Colletier JP , Sanson B , Nachon F , Gabellieri E , Fattorusso C , Campiani G , Weik M
Ref : Journal of the American Chemical Society , 128 :4526 , 2006
Abstract :
PubMedSearch : Colletier_2006_J.Am.Chem.Soc_128_4526
PubMedID: 16594661
Gene_locus related to this paper: torca-ACHE

Title : Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging - Nachon_2005_Biochemistry_44_1154
Author(s) : Nachon F , Asojo OA , Borgstahl GE , Masson P , Lockridge O
Ref : Biochemistry , 44 :1154 , 2005
Abstract :
PubMedSearch : Nachon_2005_Biochemistry_44_1154
PubMedID: 15667209
Gene_locus related to this paper: human-BCHE

Title : [Butyrylcholinesterase: 3D structure, catalytic mechanisms] - Nachon_2005_Ann.Pharm.Fr_63_194
Author(s) : Nachon F , Nicolet Y , Masson P
Ref : Ann Pharm Fr , 63 :194 , 2005
Abstract :
PubMedSearch : Nachon_2005_Ann.Pharm.Fr_63_194
PubMedID: 15976688

Title : Structural data on the aging of diethylphosphoryl-butyrylcholinesterase -
Author(s) : Nachon F , Asojo OA , Borgstahl GE , Masson P , Lockridge O
Ref : Chemico-Biological Interactions , 157-158 :408 , 2005
PubMedID: 16429549

Title : The reactant state for substrate-activated turnover of acetylthiocholine by butyrylcholinesterase is a tetrahedral intermediate - Tormos_2005_J.Am.Chem.Soc_127_14538
Author(s) : Tormos JR , Wiley KL , Seravalli J , Nachon F , Masson P , Nicolet Y , Quinn DM
Ref : Journal of the American Chemical Society , 127 :14538 , 2005
Abstract :
PubMedSearch : Tormos_2005_J.Am.Chem.Soc_127_14538
PubMedID: 16231883

Title : Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics - Masson_2005_Chem.Biol.Interact_157-158_143
Author(s) : Masson P , Schopfer LM , Froment MT , Debouzy JC , Nachon F , Gillon E , Lockridge O , Hrabovska A , Goldstein BN
Ref : Chemico-Biological Interactions , 157-158 :143 , 2005
Abstract :
PubMedSearch : Masson_2005_Chem.Biol.Interact_157-158_143
PubMedID: 16256969

Title : Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants - Wang_2004_Anal.Biochem_329_131
Author(s) : Wang Y , Schopfer LM , Duysen EG , Nachon F , Masson P , Lockridge O
Ref : Analytical Biochemistry , 329 :131 , 2004
Abstract :
PubMedSearch : Wang_2004_Anal.Biochem_329_131
PubMedID: 15136175

Title : Poster (49) Crystallographic basis for substrate\/product exchange in cholinesterases. -
Author(s) : Nicolet Y , Lockridge O , Masson P , Fontecilla-Camps JC , Nachon F
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :347 , 2004
PubMedID:

Title : Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior - Masson_2004_Eur.J.Biochem_271_1980
Author(s) : Masson P , Bec N , Froment MT , Nachon F , Balny C , Lockridge O , Schopfer LM
Ref : European Journal of Biochemistry , 271 :1980 , 2004
Abstract :
PubMedSearch : Masson_2004_Eur.J.Biochem_271_1980
PubMedID: 15128307

Title : Hysteresis in butyrylcholinesterase catalysis. -
Author(s) : Masson P , Froment MT , Nachon F , Schopfer LM
Ref : Cholinergic Mechanisms, CRC Press :637 , 2004
PubMedID:

Title : X-Ray structures of native and soman-aged human butyrylcholinesterase. -
Author(s) : Nachon F , Nicolet Y , Masson P , Lockridge O , Fontecilla-Camps JC
Ref : Cholinergic Mechanisms, CRC Press :165 , 2004
PubMedID:

Title : Poster (93) How do the crystal structures of human butyrylcholinesterase compare to torpedo californica acetylcholinesterases structures? -
Author(s) : Nachon F , Nicolet Y , Masson P , Lockridge O , Fontecilla-Camps JC
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :369 , 2004
PubMedID:

Title : Hysteretic behavior of butyrylcholinesterase: Kinetic curiosity or catalytically and physiologicaly significant? -
Author(s) : Masson P , Froment MT , Nachon F , Lockridge O , Schopfer LM
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :191 , 2004
PubMedID:

Title : Poster (20) Hysteretic behavior of butyrylcholinesterase : kinetic curiosity or catalytically and physiologically significant? -
Author(s) : Masson P , Froment MT , Nachon F , Lockridge O , Schopfer LM
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :331 , 2004
PubMedID:

Title : Photoreversible inhibition of cholinesterases: catalytic serine-labeled caged butyrylcholinesterase - Loudwig_2003_Chembiochem_4_762
Author(s) : Loudwig S , Nicolet Y , Masson P , Fontecilla-Camps JC , Bon S , Nachon F , Goeldner M
Ref : Chembiochem , 4 :762 , 2003
Abstract :
PubMedSearch : Loudwig_2003_Chembiochem_4_762
PubMedID: 12898628

Title : Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products - Nicolet_2003_J.Biol.Chem_278_41141
Author(s) : Nicolet Y , Lockridge O , Masson P , Fontecilla-Camps JC , Nachon F
Ref : Journal of Biological Chemistry , 278 :41141 , 2003
Abstract :
PubMedSearch : Nicolet_2003_J.Biol.Chem_278_41141
PubMedID: 12869558
Gene_locus related to this paper: human-BCHE

Title : High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine - Masson_2003_Eur.J.Biochem_270_315
Author(s) : Masson P , Nachon F , Bartels CF , Froment MT , Ribes F , Matthews C , Lockridge O
Ref : European Journal of Biochemistry , 270 :315 , 2003
Abstract :
PubMedSearch : Masson_2003_Eur.J.Biochem_270_315
PubMedID: 12605682

Title : Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite - Masson_2002_Biochim.Biophys.Acta_1594_313
Author(s) : Masson P , Schopfer LM , Bartels CF , Froment MT , Ribes F , Nachon F , Lockridge O
Ref : Biochimica & Biophysica Acta , 1594 :313 , 2002
Abstract :
PubMedSearch : Masson_2002_Biochim.Biophys.Acta_1594_313
PubMedID: 11904227

Title : Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization - Nachon_2002_Eur.J.Biochem_269_630
Author(s) : Nachon F , Nicolet Y , Viguie N , Masson P , Fontecilla-Camps JC , Lockridge O
Ref : European Journal of Biochemistry , 269 :630 , 2002
Abstract :
PubMedSearch : Nachon_2002_Eur.J.Biochem_269_630
PubMedID: 11856322

Title : Photoaffinity labeling with [3H]DDF support the existence of two quaternary ammonium binding domains in human butyrylcholinesterase -
Author(s) : Nachon F , Ehret-Sabatier L , Goeldner M
Ref : Journal de Physiologie (Paris) , 92 :473 , 1998
PubMedID:

Title : Site-Directed Photo-Probes for Structural and Functional Investigations on Cholinesterases -
Author(s) : Nachon F , Colas C , Peng L , Ehret-Sabatier L , Goeldner M
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :379 , 1998
PubMedID:

Title : 2-Nitrobenzylarsonium Compounds That Photorelease Heavy-Atom Cholinergic Ligands for Time-Resolved Crystallographic Studies on Cholinesterases - Peng_1998_Angew.Chem.Int.Ed.Engl_37_2691
Author(s) : Peng L , Nachon F , Wirz J , Goeldner M
Ref : Angew Chem Int Ed Engl , 37 :2691 , 1998
Abstract :
PubMedSearch : Peng_1998_Angew.Chem.Int.Ed.Engl_37_2691
PubMedID: 29711614

Title : Trp82 and Tyr332 are involved in two quaternary ammonium binding domains of human butyrylcholinesterase as revealed by photoaffinity labeling with [3H]DDF - Nachon_1998_Biochemistry_37_10507
Author(s) : Nachon F , Ehret-Sabatier L , Loew D , Colas C , Van Dorsselaer A , Goeldner M
Ref : Biochemistry , 37 :10507 , 1998
Abstract :
PubMedSearch : Nachon_1998_Biochemistry_37_10507
PubMedID: 9671522

Title : Photoaffinity Labeling with [3H]-DDF Reveals TRP82 and TYR332 are Involved in Two Quaternary Ammonium Binding Domains of Human Butyrylcholinesterase -
Author(s) : Nachon F , Ehret-Sabatier L , Goeldner M
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :236 , 1998
PubMedID:

Title : Irreversible Site-Directed Labeling Studies on Cholinesterases -
Author(s) : Ehret-Sabatier L , Schalk I , Loeb C , Nachon F , Goeldner M
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :163 , 1995
PubMedID: