Title : Selective breeding for differences in cholinergic function: pre- and postsynaptic mechanisms involved in sensitivity to the anticholinesterase, DFP - Overstreet_1984_Brain.Res_294_327 |
Author(s) : Overstreet DH , Russell RW , Crocker AD , Schiller GD |
Ref : Brain Research , 294 :327 , 1984 |
Abstract :
To determine the contribution of presynaptic cholinergic mechanisms to the increased sensitivity of a genetically selected line of Sprague-Dawley rats (Flinders S-line) to the anticholinesterase, diisopropyl fluorophosphate (DFP), rats were sacrificed by focused microwave irradiation of the head 1 min after a pulse injection of deuterium-labeled choline into the tail vein. The S-line rats exhibited higher concentrations of labeled acetylcholine (ACh) in the cortex than the rats bred for resistance to DFP (Flinders R-line). To determine the contribution of postsynaptic cholinergic mechanisms the concentration of brain muscarinic ACh receptors (mAChR) was determined. The S-line rats exhibited higher concentrations of striatal and hippocampal mAChR than the R-line rats. Thus, both pre- and postsynaptic cholinergic mechanisms may contribute to the increased sensitivity to DFP but their relative importance varies with brain region: increased ACh synthesis in the cortex and increased concentrations of mAChR in the striatum and hippocampus. |
PubMedSearch : Overstreet_1984_Brain.Res_294_327 |
PubMedID: 6704730 |
Overstreet DH, Russell RW, Crocker AD, Schiller GD (1984)
Selective breeding for differences in cholinergic function: pre- and postsynaptic mechanisms involved in sensitivity to the anticholinesterase, DFP
Brain Research
294 :327
Overstreet DH, Russell RW, Crocker AD, Schiller GD (1984)
Brain Research
294 :327