| Title : A recombinant vaccine expressing a mammalian Mycobacterium sp. antigen is immunostimulatory but not protective in striped bass - Pasnik_2003_Vet.Immunol.Immunopathol_95_43 |
| Author(s) : Pasnik DJ , Vemulapalli R , Smith SA , Schurig GG |
| Ref : Vet Immunol Immunopathol , 95 :43 , 2003 |
|
Abstract :
A recombinant vaccine was constructed for piscine mycobacteriosis utilizing a Brucella abortus strain RB51 vector expressing a mammalian Mycobacterium sp. 85A antigen. Juvenile striped bass were inoculated with the resulting construct at doses equivalent to 10(6), 10(7), 10(8), 10(9), and 10(10) colony-forming units/fish. Blood and tissue samples from these fish demonstrated significant specific humoral and cell-mediated immune responses towards the 85A antigen in a dose-dependent manner. However, survival studies determined that inoculated fish failed to demonstrate cross-protective responses after live Mycobacterium marinum challenge 70 days post-inoculation. |
| PubMedSearch : Pasnik_2003_Vet.Immunol.Immunopathol_95_43 |
| PubMedID: 12969635 |
| Gene_locus related to this paper: mycul-a85a |
| Gene_locus | mycul-a85a |
Pasnik DJ, Vemulapalli R, Smith SA, Schurig GG (2003)
A recombinant vaccine expressing a mammalian Mycobacterium sp. antigen is immunostimulatory but not protective in striped bass
Vet Immunol Immunopathol
95 :43
Pasnik DJ, Vemulapalli R, Smith SA, Schurig GG (2003)
Vet Immunol Immunopathol
95 :43