Smith SA

References (8)

Title : Comparing Longitudinal Measures of Cholinesterase as Biomarkers for Insecticide Exposure Among Latinx Children in Rural Farmworker and Urban Non-Farmworker Communities in North Carolina - Quandt_2023_J.Occup.Environ.Med__
Author(s) : Quandt SA , Smith SA , Arcury TA , Chen H , Hester K , Pope CN , Anderson KA , Laurienti PJ
Ref : J Occup Environ Med , : , 2023
Abstract : OBJECTIVE: In a two-group prospective design, this study compares seasonal cholinesterase levels of Latinx children in rural farmworker families and comparable urban children, to assess the impact of environmental exposure to cholinesterase-inhibiting insecticides. METHODS: Quarterly blood samples and passive dosimeter wristbands were collected over 2 years in 8 year old children (74 rural, 62 urban). Laboratory analysis assessed total cholinesterase (total ChE), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) from blood samples, and insecticides from wristbands. RESULTS: In spring and summer, total ChE and AChE levels were depressed in rural children compared to winter and fall. BChE was depressed in rural children in fall, compared to spring and summer. Adjustment for insecticide exposure did not affect these associations. CONCLUSIONS: Environmental exposures to cholinesterase-inhibiting insecticides have measurable biochemical effects on blood cholinesterases in rural children from farmworker families.
ESTHER : Quandt_2023_J.Occup.Environ.Med__
PubMedSearch : Quandt_2023_J.Occup.Environ.Med__
PubMedID: 37696813

Title : Complete Genome Sequence of Sphingobacterium sp. Strain ML3W, Isolated from Wings of Myotis lucifugus Infected with White Nose Syndrome - Smith_2015_Genome.Announc_3_e01477
Author(s) : Smith SA , Krasucki SP , McDowell JV , Balke VL
Ref : Genome Announc , 3 : , 2015
Abstract : Sphingobacterium sp. strain ML3W was isolated from the wing of a bat infected with white nose syndrome. We report the complete 5.33-Mb genome sequence of Sphingobacterium sp. strain ML3W, obtained using Pacific Biosciences technology. Being the second complete Sphingobacterium sequence, this will increase knowledge of the genus.
ESTHER : Smith_2015_Genome.Announc_3_e01477
PubMedSearch : Smith_2015_Genome.Announc_3_e01477
PubMedID: 25614576
Gene_locus related to this paper: 9sphi-a0a088ex14 , 9sphi-a0a088ewe4

Title : The genome of the ctenophore Mnemiopsis leidyi and its implications for cell type evolution - Ryan_2013_Science_342_1242592
Author(s) : Ryan JF , Pang K , Schnitzler CE , Nguyen AD , Moreland RT , Simmons DK , Koch BJ , Francis WR , Havlak P , Smith SA , Putnam NH , Haddock SH , Dunn CW , Wolfsberg TG , Mullikin JC , Martindale MQ , Baxevanis AD
Ref : Science , 342 :1242592 , 2013
Abstract : An understanding of ctenophore biology is critical for reconstructing events that occurred early in animal evolution. Toward this goal, we have sequenced, assembled, and annotated the genome of the ctenophore Mnemiopsis leidyi. Our phylogenomic analyses of both amino acid positions and gene content suggest that ctenophores rather than sponges are the sister lineage to all other animals. Mnemiopsis lacks many of the genes found in bilaterian mesodermal cell types, suggesting that these cell types evolved independently. The set of neural genes in Mnemiopsis is similar to that of sponges, indicating that sponges may have lost a nervous system. These results present a newly supported view of early animal evolution that accounts for major losses and/or gains of sophisticated cell types, including nerve and muscle cells.
ESTHER : Ryan_2013_Science_342_1242592
PubMedSearch : Ryan_2013_Science_342_1242592
PubMedID: 24337300
Gene_locus related to this paper: 9metz-v9pnu4 , 9metz-v9pp08 , 9metz-v9ppb4 , 9metz-v9ppy2 , 9metz-v9ppa3 , 9metz-v9ppq7 , 9metz-v9ppk9 , 9metz-v9pps9 , 9metz-v9ppj6

Title : Inactivation of prefrontal cortex abolishes cortical acetylcholine release evoked by sensory or sensory pathway stimulation in the rat - Rasmusson_2007_Neurosci_149_232
Author(s) : Rasmusson DD , Smith SA , Semba K
Ref : Neuroscience , 149 :232 , 2007
Abstract : Sensory stimulation and electrical stimulation of sensory pathways evoke an increase in acetylcholine release from the corresponding cortical areas. The pathways by which such sensory information reaches the cholinergic neurons of the basal forebrain that are responsible for this release are unclear, but have been hypothesized to pass through the prefrontal cortex (PFC). This hypothesis was tested in urethane-anesthetized rats using microdialysis to collect acetylcholine from somatosensory, visual, or auditory cortex, before and after the PFC was inactivated by local microdialysis delivery of the GABA-A receptor agonist muscimol (0.2% for 10 min at 2 microl/min). Before PFC inactivation, peripheral sensory stimulation and ventral posterolateral thalamic stimulation evoked 60 and 105% increases, respectively, in acetylcholine release from somatosensory cortex. Stimulation of the lateral geniculate nucleus evoked a 57% increase in acetylcholine release from visual cortex and stimulation of the medial geniculate nucleus evoked a 72% increase from auditory cortex. Muscimol delivery to the PFC completely abolished each of these evoked increases (overall mean change from baseline = -7%). In addition, the spontaneous level of acetylcholine release in somatosensory, visual, and auditory cortices was reduced by 15-59% following PFC inactivation, suggesting that PFC activity has a tonic facilitatory influence on the basal forebrain cholinergic neurons. These experiments demonstrate that the PFC is necessary for sensory pathway evoked cortical ACh release and strongly support the proposed sensory cortex-to-PFC-to-basal forebrain circuit for each of these modalities.
ESTHER : Rasmusson_2007_Neurosci_149_232
PubMedSearch : Rasmusson_2007_Neurosci_149_232
PubMedID: 17850979

Title : A recombinant vaccine expressing a mammalian Mycobacterium sp. antigen is immunostimulatory but not protective in striped bass - Pasnik_2003_Vet.Immunol.Immunopathol_95_43
Author(s) : Pasnik DJ , Vemulapalli R , Smith SA , Schurig GG
Ref : Vet Immunol Immunopathol , 95 :43 , 2003
Abstract : A recombinant vaccine was constructed for piscine mycobacteriosis utilizing a Brucella abortus strain RB51 vector expressing a mammalian Mycobacterium sp. 85A antigen. Juvenile striped bass were inoculated with the resulting construct at doses equivalent to 10(6), 10(7), 10(8), 10(9), and 10(10) colony-forming units/fish. Blood and tissue samples from these fish demonstrated significant specific humoral and cell-mediated immune responses towards the 85A antigen in a dose-dependent manner. However, survival studies determined that inoculated fish failed to demonstrate cross-protective responses after live Mycobacterium marinum challenge 70 days post-inoculation.
ESTHER : Pasnik_2003_Vet.Immunol.Immunopathol_95_43
PubMedSearch : Pasnik_2003_Vet.Immunol.Immunopathol_95_43
PubMedID: 12969635
Gene_locus related to this paper: mycul-a85a

Title : The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2 - Blackie_2003_Bioorg.Med.Chem.Lett_13_1067
Author(s) : Blackie JA , Bloomer JC , Brown MJ , Cheng HY , Hammond B , Hickey DM , Ife RJ , Leach CA , Lewis VA , Macphee CH , Milliner KJ , Moores KE , Pinto IL , Smith SA , Stansfield IG , Stanway SJ , Taylor MA , Theobald CJ
Ref : Bioorganic & Medicinal Chemistry Lett , 13 :1067 , 2003
Abstract : Modification of the pyrimidone 5-substituent in clinical candidate SB-435495 has given a series of inhibitors of recombinant lipoprotein-associated phospholipase A(2) with sub-nanomolar potency. Cyclopentyl fused derivative 21, SB-480848, showed an enhanced in vitro and in vivo profile versus SB-435495 and has been selected for progression to man.
ESTHER : Blackie_2003_Bioorg.Med.Chem.Lett_13_1067
PubMedSearch : Blackie_2003_Bioorg.Med.Chem.Lett_13_1067
PubMedID: 12643913

Title : The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2 - Boyd_2001_Bioorg.Med.Chem.Lett_11_701
Author(s) : Boyd HF , Hammond B , Hickey DM , Ife RJ , Leach CA , Lewis VA , Macphee CH , Milliner KJ , Pinto IL , Smith SA , Stansfield IG , Theobald CJ , Whittaker CM
Ref : Bioorganic & Medicinal Chemistry Lett , 11 :701 , 2001
Abstract : Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase A2, has given inhibitors of nanomolar potency and improved physicochemical properties. Compound 23 was identified as a potent, highly water soluble. CNS penetrant inhibitor suitable for intravenous administration.
ESTHER : Boyd_2001_Bioorg.Med.Chem.Lett_11_701
PubMedSearch : Boyd_2001_Bioorg.Med.Chem.Lett_11_701
PubMedID: 11266173

Title : 2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2 - Boyd_2000_Bioorg.Med.Chem.Lett_10_395
Author(s) : Boyd HF , Flynn ST , Hickey DM , Ife RJ , Jones M , Leach CA , Macphee CH , Milliner KJ , Rawlings DA , Slingsby BP , Smith SA , Stansfield IG , Tew DG , Theobald CJ
Ref : Bioorganic & Medicinal Chemistry Lett , 10 :395 , 2000
Abstract : Starting from two weakly active hits from high throughput screening, a novel series of 2-(alkylthio)-pyrimidin-4-ones with high potency and selectivity for lipoprotein-associated phospholipase A2 has been designed. In contrast to previously known inhibitors, these have been shown to act by a non-covalent and substrate competitive mechanism.
ESTHER : Boyd_2000_Bioorg.Med.Chem.Lett_10_395
PubMedSearch : Boyd_2000_Bioorg.Med.Chem.Lett_10_395
PubMedID: 10714508