| Title : Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase - Pecic_2012_Bioorg.Med.Chem.Lett_22_601 |
| Author(s) : Pecic S , Deng SX , Morisseau C , Hammock BD , Landry DW |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :601 , 2012 |
|
Abstract :
Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a new pharmaceutical approach for treating hypertension and vascular inflammation. The most potent sEH inhibitors reported in literature to date are urea derivatives. However, these compounds have limited pharmacokinetic profiles. We investigated non-urea amide derivatives as sEH inhibitors and identified a potent human sEH inhibitor 14-34 having potency comparable to urea-based inhibitors. |
| PubMedSearch : Pecic_2012_Bioorg.Med.Chem.Lett_22_601 |
| PubMedID: 22079754 |
Pecic S, Deng SX, Morisseau C, Hammock BD, Landry DW (2012)
Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase
Bioorganic & Medicinal Chemistry Lett
22 :601
Pecic S, Deng SX, Morisseau C, Hammock BD, Landry DW (2012)
Bioorganic & Medicinal Chemistry Lett
22 :601