Title : Acute changes in pulmonary function following microinstillation inhalation exposure to soman in nonatropenized guinea pigs - Perkins_2011_Int.J.Toxicol_30_348 |
Author(s) : Perkins MW , Pierre Z , Rezk P , Song J , Oguntayo S , Sciuto AM , Doctor BP , Nambiar MP |
Ref : Int J Toxicol , 30 :348 , 2011 |
Abstract :
Barometric whole-body plethysmography (WBP) was used to examine pulmonary functions at 4 and 24 hours postexposure to soman (GD) in guinea pigs without therapeutics to improve survival. Endotracheal aerosolization by microinstillation was used to administer GD (280, 561, and 841 mg/m(3)) or saline to anesthetized guinea pigs. Significant increases in respiratory frequency (RF), tidal volume (TV), and minute volume (MV) were observed with 841 mg/m(3) GD at 4 hours and that were reduced at 24 hours postexposure. A dose-dependent increase in peak inspiration flow and peak expiration flow was present at 4-hour post-GD exposure that was reduced at 24 hours. Time of inspiration and expiration were decreased in all doses of GD exposure at 4 and 24 hours, with significant inhibition at 841 mg/m(3). End-expiratory pause (EEP) increased at 280 and 561 mg/m(3), but decreased in animals exposed 841 mg/m(3) at 24 hours postexposure. Pseudo-lung resistance (Penh) and pause followed similar patterns and increased at 4 hours, but decreased at 24 hours postexposure to 841 mg/m(3) of GD compared to control. These studies indicate GD exposure induces dose-dependent changes in pulmonary function that are significant at 841 mg/m(3) at 4 hours and remains 24 hours postexposure. Furthermore, at 4 hours, GD induces bronchoconstriction possibly due to copious airway secretion and ongoing lung injury in addition to cholinergic effects, while at 24 hours GD induces bronchodilation a possible consequence of initial compensatory mechanisms. |
PubMedSearch : Perkins_2011_Int.J.Toxicol_30_348 |
PubMedID: 21527644 |
Perkins MW, Pierre Z, Rezk P, Song J, Oguntayo S, Sciuto AM, Doctor BP, Nambiar MP (2011)
Acute changes in pulmonary function following microinstillation inhalation exposure to soman in nonatropenized guinea pigs
Int J Toxicol
30 :348
Perkins MW, Pierre Z, Rezk P, Song J, Oguntayo S, Sciuto AM, Doctor BP, Nambiar MP (2011)
Int J Toxicol
30 :348