| Title : A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists - Perrone_2006_Bioorg.Med.Chem_14_1207 |
| Author(s) : Perrone MG , Santandrea E , Giorgio E , Bleve L , Scilimati A , Tortorella P |
| Ref : Bioorganic & Medicinal Chemistry , 14 :1207 , 2006 |
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Abstract :
Enantiomerically pure (R)-2-chloro-1-(pyridin-3-yl)ethanol has been prepared by kinetic resolution performed in the presence of Candida antarctica SP435-L lipase immobilized on a macroporous polyacrylate resin (Novozym 435). It was converted into (R)-1-(pyridin-3-yl)-2-aminoethanol, left-hand side of beta(3)-adrenergic receptor ligands. |
| PubMedSearch : Perrone_2006_Bioorg.Med.Chem_14_1207 |
| PubMedID: 16216512 |
Perrone MG, Santandrea E, Giorgio E, Bleve L, Scilimati A, Tortorella P (2006)
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists
Bioorganic & Medicinal Chemistry
14 :1207
Perrone MG, Santandrea E, Giorgio E, Bleve L, Scilimati A, Tortorella P (2006)
Bioorganic & Medicinal Chemistry
14 :1207