| Title : An aminomethylpyrimidine DPP-IV inhibitor with improved properties - Peters_2004_Bioorg.Med.Chem.Lett_14_3575 |
| Author(s) : Peters JU , Hunziker D , Fischer H , Kansy M , Weber S , Kritter S , Muller A , Wallier A , Ricklin F , Boehringer M , Poli SM , Csato M , Loeffler BM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :3575 , 2004 |
|
Abstract :
A recently identified DPP-IV inhibitor (1) was found to induce phospholipidosis and to inhibit CYP3A4. A small series of less lipophilic and less amphiphilic analogues was synthesized in an effort to overcome these issues. One compound from this series was equipotent to 1, did not induce phospholipidosis and showed a reduced CYP3A4 inhibition. |
| PubMedSearch : Peters_2004_Bioorg.Med.Chem.Lett_14_3575 |
| PubMedID: 15177477 |
Peters JU, Hunziker D, Fischer H, Kansy M, Weber S, Kritter S, Muller A, Wallier A, Ricklin F, Boehringer M, Poli SM, Csato M, Loeffler BM (2004)
An aminomethylpyrimidine DPP-IV inhibitor with improved properties
Bioorganic & Medicinal Chemistry Lett
14 :3575
Peters JU, Hunziker D, Fischer H, Kansy M, Weber S, Kritter S, Muller A, Wallier A, Ricklin F, Boehringer M, Poli SM, Csato M, Loeffler BM (2004)
Bioorganic & Medicinal Chemistry Lett
14 :3575