Petroianu_2013_J.Appl.Toxicol_33_894

Reference

Title : Usefulness of administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using paraoxon - Petroianu_2013_J.Appl.Toxicol_33_894
Author(s) : Petroianu GA , Nurulain SM , Shafiullah M , Hasan MY , Kuca K , Lorke DE
Ref : Journal of Applied Toxicology , 33 :894 , 2013
Abstract :

Reversible acetylcholinesterase (AChE) inhibitors can protect against the lethal effects of irreversible organophosphorus AChE inhibitors (OPCs), when administered before OPC exposure. We have assessed in vivo the mortality-reducing efficacy of a group of known AChE inhibitors, when given in equitoxic dosage before exposure to the OPC paraoxon. Protection was quantified in rats by determining the relative risk (RR) of death. Best in vivo protection from paraoxon-induced mortality was observed after prophylactic administration of physostigmine (RR = 0.30) or the oxime K-27 (RR = 0.34); both treatments were significantly superior to the pre-treatment with all other tested compounds, including the established substance pyridostigmine. Tacrine (RR = 0.67), ranitidine (RR = 0.72), pyridostigmine (RR = 0.76), tiapride (RR = 0.80) and 7-MEOTA (RR = 0.86) also significantly reduced the relative risk of paraoxon-induced death, but to a lesser degree. Methylene blue, amiloride and metoclopramide had an unfavorable effect (RR >/= 1), significantly increasing mortality. When CNS penetration by prophylactic is undesirable K-27 is a promising alternative to pyridostigmine. Copyright (c) 2012 John Wiley & Sons, Ltd.

PubMedSearch : Petroianu_2013_J.Appl.Toxicol_33_894
PubMedID: 22611016

Related information

Citations formats

Petroianu GA, Nurulain SM, Shafiullah M, Hasan MY, Kuca K, Lorke DE (2013)
Usefulness of administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using paraoxon
Journal of Applied Toxicology 33 :894

Petroianu GA, Nurulain SM, Shafiullah M, Hasan MY, Kuca K, Lorke DE (2013)
Journal of Applied Toxicology 33 :894