Pinault_2013_Antimicrob.Agents.Chemother_57_2134

Reference

Title : Zafirlukast inhibits complexation of Lsr2 with DNA and growth of Mycobacterium tuberculosis - Pinault_2013_Antimicrob.Agents.Chemother_57_2134
Author(s) : Pinault L , Han JS , Kang CM , Franco J , Ronning DR
Ref : Antimicrobial Agents & Chemotherapy , 57 :2134 , 2013
Abstract :

The mycobacterial nucleoid-associated protein Lsr2 is a DNA-bridging protein that plays a role in condensation and structural organization of the genome and acts as a global repressor of gene transcription. Here we describe experiments demonstrating that zafirlukast inhibits the complexation between Lsr2 and DNA in vitro. Zafirlukast is shown to inhibit growth in two different species of mycobacteria tested but exhibits no growth inhibition of Escherichia coli. The Lsr2 inhibitory activity is reflected in vivo as determined by monitoring of transcription levels in Mycobacterium tuberculosis. These data suggest that zafirlukast inhibits Lsr2 function in vivo, promoting dysregulation of the expression of an array of genes typically bound by Lsr2 and hindering growth. Since zafirlukast likely operates by a mechanism distinct from current M. tuberculosis drugs and is currently used as a prophylactic treatment for asthma, it offers an intriguing lead for development of new treatments for tuberculosis.

PubMedSearch : Pinault_2013_Antimicrob.Agents.Chemother_57_2134
PubMedID: 23439641

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Citations formats

Pinault L, Han JS, Kang CM, Franco J, Ronning DR (2013)
Zafirlukast inhibits complexation of Lsr2 with DNA and growth of Mycobacterium tuberculosis
Antimicrobial Agents & Chemotherapy 57 :2134

Pinault L, Han JS, Kang CM, Franco J, Ronning DR (2013)
Antimicrobial Agents & Chemotherapy 57 :2134