Title : Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity - Proskocil_2008_Environ.Health.Perspect_116_381 |
Author(s) : Proskocil BJ , Bruun DA , Lorton JK , Blensly KC , Jacoby DB , Lein PJ , Fryer AD |
Ref : Environmental Health Perspectives , 116 :381 , 2008 |
Abstract :
BACKGROUND: Recent epidemiologic studies have identified organophosphorus pesticides (OPs) as environmental factors potentially contributing to the increase in asthma prevalence over the last 25 years. In support of this hypothesis, we have demonstrated that environmentally relevant concentrations of OPs induce airway hyperreactivity in guinea pigs. OBJECTIVES: Sensitization to allergen is a significant contributing factor in asthma, and we have shown that sensitization changes virus-induced airway hyperreactivity from an eosinophil-independent mechanism to one mediated by eosinophils. Here, we determine whether sensitization similarly influences OP-induced airway hyperreactivity. |
PubMedSearch : Proskocil_2008_Environ.Health.Perspect_116_381 |
PubMedID: 18335107 |
Proskocil BJ, Bruun DA, Lorton JK, Blensly KC, Jacoby DB, Lein PJ, Fryer AD (2008)
Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity
Environmental Health Perspectives
116 :381
Proskocil BJ, Bruun DA, Lorton JK, Blensly KC, Jacoby DB, Lein PJ, Fryer AD (2008)
Environmental Health Perspectives
116 :381