Prozorovskii_1983_Biull.Eksp.Biol.Med_96_66

Reference

Title : [Trial of cholinesterase reactivators as proserine antagonists]. [Russian] - Prozorovskii_1983_Biull.Eksp.Biol.Med_96_66
Author(s) : Prozorovskii VB , Khramova EA , Ardab'eva TV
Ref : Biulleten Eksperimentalnoi Biologii i Meditsiny , 96 :66 , 1983
Abstract :

HI-6 and TMB-4(Trimedoxime) were the most effective and safe of 7 cholinesterase reactivators tested as agents for the prophylaxis of proserine poisoning of male mice. The reactivator HI-6 strongly potentiated the prophylactic efficacy of a mixture of atropine and arpenal administered in the doses sufficient for the blockade of both the m- and h-cholinoreactive systems of mice. As demonstrated by experiments in vitro, HI-6 and TMB-4(Trimedoxime) did not reacivate proserine-inhibited cholinesterase. The natural anticholinesterase activity of HI-6 was negligible. Based on the correlation of the data obtained to the reported data indicating that HI-6 has a low ganglioblocking activity it is inferred that the direct effect on the receptor is of no importance for the potentiating effect. It is assumed that HI-6 modulates the cholinoreactive systems, which leads to a dramatic increase of the efficacy of cholinolytics.

PubMedSearch : Prozorovskii_1983_Biull.Eksp.Biol.Med_96_66
PubMedID: 6354300

Related information

Reactivator HS-3    HI-6    Trimedoxime

Citations formats

Prozorovskii VB, Khramova EA, Ardab'eva TV (1983)
[Trial of cholinesterase reactivators as proserine antagonists]. [Russian]
Biulleten Eksperimentalnoi Biologii i Meditsiny 96 :66

Prozorovskii VB, Khramova EA, Ardab'eva TV (1983)
Biulleten Eksperimentalnoi Biologii i Meditsiny 96 :66