HI-6
General
Type : Oxime, Bispyridinium, Carboxamide, Hagedorn Oxime
Chemical_Nomenclature : [(E)-[1-[(4-carbamoylpyridin-1-ium-1-yl)methoxymethyl]pyridin-2-ylidene]methyl]-oxoazanium\;dichloride, 1-[[2-[(E)-hydroxyiminomethyl]pyridin-1-ium-1-yl]methoxymethyl]pyridin-1-ium-4-carboxamide\;dichloride, 1-[[2-[(Z)-hydroxyiminomethyl]pyridin-1-ium-1-yl]methoxymethyl]pyridin-1-ium-4-carboxamide\;methanesulfonate
Canonical SMILES : C1=CC(=C[NH+]=O)N(C=C1)COC[N+]2=CC=C(C=C2)C(=O)N.[Cl-].[Cl-] || C1=CC=[N+](C(=C1)C=NO)COC[N+]2=CC=C(C=C2)C(=O)N.[Cl-].[Cl-] || CS(=O)(=O)[O-].CS(=O)(=O)[O-].C1=CC=[N+](C(=C1)C=NO)COC[N+]2=CC=C(C=C2)C(=O)N
InChI : InChI=1S\/C14H14N4O3.2ClH\/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20\;\;\/h1-9H,10-11H2,(H-,15,19)\;2*1H\/b13-9+\;\;, InChI=1S\/C14H14N4O3.2ClH\/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20\;\;\/h1-9H,10-11H2,(H-,15,19)\;2*1H, InChI=1S\/C14H14N4O3.2CH4O3S\/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20\;2*1-5(2,3)4\/h1-9H,10-11H2,(H-,15,19)\;2*1H3,(H,2,3,4)
InChIKey : QELSIJXWEROXOE-IGUOPLJTSA-N, QELSIJXWEROXOE-UHFFFAOYSA-N, KSZUKDJWBYNHBO-UHFFFAOYSA-N
Other name(s) : 1-(((4-(aminocarbonyl)pyridinio)methoxy)methyl)-2-((hydr oxyimino)methyl pyridinium dichloride monohydrate 1,1'-[oxybis(methylene)]-[4-carbamoyl-2'-(hydroxyimino)methyl]pyridinium dichloride || Asoxime chloride || Asoxime || CCRIS 7699 || HJ 6 || HI 6 || HI6 || UNII-HUV88P6SJS || HUV88P6SJS || HI-6 Dichloride || Asoxime (dichloride) || SCHEMBL667540 || SCHEMBL840733 || SCHEMBL20917382 || Asoxime dimethanesulfonate || Q27290555
MW : 359.20 || 478.5
Formula : C14H16Cl2N4O3 || C16H22N4O9S2
CAS_number : 34433-31-3
PubChem : 135444627, 6101642, 135590422
UniChem : QELSIJXWEROXOE-IGUOPLJTSA-N, QELSIJXWEROXOE-UHFFFAOYSA-N, KSZUKDJWBYNHBO-UHFFFAOYSA-N
Wikipedia : Asoxime_chloride
References (67)
| Title : Accelerating countermeasure candidate discovery for A-series chemical warfare agent exposure - Morato_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2512471122 |
| Author(s) : Morato NM , Mason KE , Corzett TH , Valdez CA , Alfaro TM , Hok S , Cooks RG , Mayer BP |
| Ref : Proc Natl Acad Sci U S A , 122 :e2512471122 , 2025 |
| Abstract : |
| PubMedSearch : Morato_2025_Proc.Natl.Acad.Sci.U.S.A_122_e2512471122 |
| PubMedID: 40674422 |
| Title : The reactivation kinetic analysis, molecular docking, and dynamics of oximes against three V-type nerve agents inhibited four human cholinesterases - Li_2024_Chem.Biol.Interact__111061 |
| Author(s) : Li K , Liu Y , Li Q , Guo L , Xie J |
| Ref : Chemico-Biological Interactions , :111061 , 2024 |
| Abstract : |
| PubMedSearch : Li_2024_Chem.Biol.Interact__111061 |
| PubMedID: 38763347 |
| Title : Efficacy of the oxime HI-6 dimethanesulphonate in the treatment of guinea-pigs exposed to the nerve agents GB and GD - Rice_2023_Toxicol.Lett_391_26 |
| Author(s) : Rice H , Whitfield SJ , Fairhall SJ , Scott IR , Steventon GB , Tattersall JEH |
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| Title : Molecular modeling of Mannich phenols as reactivators of human acetylcholinesterase inhibited by A-series nerve agents - Vieira_2023_Chem.Biol.Interact_14ChEPon_110622 |
| Author(s) : Vieira LA , Almeida J , De Koning MC , LaPlante SR , Borges I , Franca TCC |
| Ref : Chemico-Biological Interactions , :110622 , 2023 |
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| PubMedSearch : Vieira_2023_Chem.Biol.Interact_14ChEPon_110622 |
| PubMedID: 37442286 |
| Title : Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6 - McGuire_2021_Chem.Res.Toxicol_34_804 |
| Author(s) : McGuire JR , Bester SM , Guelta MA , Cheung J , Langley C , Winemiller MD , Bae SY , Funk V , Myslinski JM , Pegan SD , Height JJ |
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| PubMedSearch : McGuire_2021_Chem.Res.Toxicol_34_804 |
| PubMedID: 33538594 |
| Gene_locus related to this paper: human-ACHE |
| Title : Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects - Blumenthal_2021_J.Biol.Chem__ |
| Author(s) : Blumenthal DK , Cheng X , Fajer M , Ho KY , Rohrer J , Gerlits O , Taylor P , Juneja P , Kovalevsky A , Radic Z |
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| PubMedSearch : Blumenthal_2021_J.Biol.Chem__ |
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| Gene_locus related to this paper: human-ACHE |
| Title : Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6 - Bester_2018_Chem.Res.Toxicol_31_1405 |
| Author(s) : Bester SM , Guelta MA , Cheung J , Winemiller MD , Bae SY , Myslinski J , Pegan SD , Height JJ |
| Ref : Chemical Research in Toxicology , 31 :1405 , 2018 |
| Abstract : |
| PubMedSearch : Bester_2018_Chem.Res.Toxicol_31_1405 |
| PubMedID: 30462502 |
| Gene_locus related to this paper: human-ACHE |
| Title : The efficacy of HI-6 DMS in a sustained infusion against percutaneous VX poisoning in the guinea-pig - Whitmore_2018_Toxicol.Lett_293_207 |
| Author(s) : Whitmore C , Cook AR , Mann T , Price ME , Emery E , Roughley N , Flint D , Stubbs S , Armstrong SJ , Rice H , Tattersall JEH |
| Ref : Toxicol Lett , 293 :207 , 2018 |
| Abstract : |
| PubMedSearch : Whitmore_2018_Toxicol.Lett_293_207 |
| PubMedID: 29129798 |
| Title : The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study - Worek_2018_Toxicol.Lett_293_216 |
| Author(s) : Worek F , Thiermann H , Wille T |
| Ref : Toxicol Lett , 293 :216 , 2018 |
| Abstract : |
| PubMedSearch : Worek_2018_Toxicol.Lett_293_216 |
| PubMedID: 28993240 |
| Title : Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6 - Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514 |
| Author(s) : Allgardsson A , Berg L , Akfur C , Hornberg A , Worek F , Linusson A , Ekstrom F |
| Ref : Proc Natl Acad Sci U S A , 113 :5514 , 2016 |
| Abstract : |
| PubMedSearch : Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514 |
| PubMedID: 27140636 |
| Gene_locus related to this paper: human-ACHE |
| Title : HI-6 treatment does not reactivate sarin inhibited acetylcholinesterase activity in dog brain when administered in human therapeutical dose 30 minutes after the poisoning - Caisberger_2016_Mil.Med.Sci.Lett_85_2 |
| Author(s) : Caisberger F , Novotny L , Hajek P , Misik J , Kassa J , Pejchal J |
| Ref : Military Medical Science Letters , 85 :2 , 2016 |
| Abstract : |
| PubMedSearch : Caisberger_2016_Mil.Med.Sci.Lett_85_2 |
| PubMedID: |
| Title : HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants - Macek Hrvat_2016_Chem.Biol.Interact_259_148 |
| Author(s) : Macek Hrvat N , Zunec S , Taylor P , Radic Z , Kovarik Z |
| Ref : Chemico-Biological Interactions , 259 :148 , 2016 |
| Abstract : |
| PubMedSearch : Macek Hrvat_2016_Chem.Biol.Interact_259_148 |
| PubMedID: 27083141 |
| Gene_locus related to this paper: human-ACHE |
| Title : Catalytic Soman Scavenging by the Y337A\/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes - Kovarik_2015_Chem.Res.Toxicol_28_1036 |
| Author(s) : Kovarik Z , Macek Hrvat N , Katalinic M , Sit RK , Paradyse A , Zunec S , Musilek K , Fokin VV , Taylor P , Radic Z |
| Ref : Chemical Research in Toxicology , 28 :1036 , 2015 |
| Abstract : |
| PubMedSearch : Kovarik_2015_Chem.Res.Toxicol_28_1036 |
| PubMedID: 25835984 |
| Title : HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs - Kunes_2014_Neuro.Endocrinol.Lett_35_186 |
| Author(s) : Kunes M , Kvetina J , Bures J , Karasova JZ , Pavlik M , Tacheci I , Musilek K , Kuca K |
| Ref : Neuro Endocrinol Lett , 35 :186 , 2014 |
| Abstract : |
| PubMedSearch : Kunes_2014_Neuro.Endocrinol.Lett_35_186 |
| PubMedID: 25638385 |
| Title : Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity - Artursson_2013_Biochem.Pharmacol_85_1389 |
| Author(s) : Artursson E , Andersson PO , Akfur C , Linusson A , Borjegren S , Ekstrom F |
| Ref : Biochemical Pharmacology , 85 :1389 , 2013 |
| Abstract : |
| PubMedSearch : Artursson_2013_Biochem.Pharmacol_85_1389 |
| PubMedID: 23376121 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Transdermal penetration of the acetylcholinesterase reactivator HI-6 in a rat model - Kracmarova_2013_Mil.Med.Sci.Lett_82_185 |
| Author(s) : Kracmarova A , Bartosova L , Karasova JZ , Zemek F , Bajgar J |
| Ref : Military Medical Science Letters , 82 :185 , 2013 |
| Abstract : |
| PubMedSearch : Kracmarova_2013_Mil.Med.Sci.Lett_82_185 |
| PubMedID: |
| Title : Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase - Worek_2012_Arch.Toxicol_86_1379 |
| Author(s) : Worek F , von der Wellen J , Musilek K , Kuca K , Thiermann H |
| Ref : Archives of Toxicology , 86 :1379 , 2012 |
| Abstract : |
| PubMedSearch : Worek_2012_Arch.Toxicol_86_1379 |
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| Title : Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70 |
| Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M |
| Ref : J Enzyme Inhib Med Chem , 23 :70 , 2008 |
| Abstract : |
| PubMedSearch : Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70 |
| PubMedID: 18341256 |
| Title : A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods - Kassa_1999_Toxicology_132_111 |
| Author(s) : Kassa J , Cabal J |
| Ref : Toxicology , 132 :111 , 1999 |
| Abstract : |
| PubMedSearch : Kassa_1999_Toxicology_132_111 |
| PubMedID: 10433374 |
| Title : A comparison of the therapeutic efficacy of conventional and modern oximes against supralethal doses of highly toxic organophosphates in mice - Kassa_1998_Acta.Medica_41_19 |
| Author(s) : Kassa J |
| Ref : Acta Medica , 41 :19 , 1998 |
| Abstract : |
| PubMedSearch : Kassa_1998_Acta.Medica_41_19 |
| PubMedID: 9588068 |
| Title : Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds - Worek_1998_Arch.Toxicol_72_237 |
| Author(s) : Worek F , Widmann R , Knopff O , Szinicz L |
| Ref : Archives of Toxicology , 72 :237 , 1998 |
| Abstract : |
| PubMedSearch : Worek_1998_Arch.Toxicol_72_237 |
| PubMedID: 9587020 |
| Title : A comparison of the efficacy of new asymmetric bispyridinium oxime BI-6 with other oximes (obidoxime, HI-6) against soman in rats - Kassa_1998_Hum.Exp.Toxicol_17_331 |
| Author(s) : Kassa J |
| Ref : Hum Exp Toxicol , 17 :331 , 1998 |
| Abstract : |
| PubMedSearch : Kassa_1998_Hum.Exp.Toxicol_17_331 |
| PubMedID: 9688357 |
| Title : Pharmacokinetics and effects of HI 6 in blood and brain of soman-intoxicated rats: a microdialysis study - Cassel_1997_Eur.J.Pharmacol_332_43 |
| Author(s) : Cassel G , Karlsson L , Waara L , Ang KW , Goransson-Nyberg A |
| Ref : European Journal of Pharmacology , 332 :43 , 1997 |
| Abstract : |
| PubMedSearch : Cassel_1997_Eur.J.Pharmacol_332_43 |
| PubMedID: 9298924 |
| Title : Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning - Worek_1997_Hum.Exp.Toxicol_16_466 |
| Author(s) : Worek F , Backer M , Thiermann H , Szinicz L , Mast U , Klimmek R , Eyer P |
| Ref : Hum Exp Toxicol , 16 :466 , 1997 |
| Abstract : |
| PubMedSearch : Worek_1997_Hum.Exp.Toxicol_16_466 |
| PubMedID: 9292287 |
| Title : [The effect of parasympatholytics on the therapeutic effectiveness of the oxime HI-6 against organophosphorus compounds (Soman, substance VX, Fosdrin) in mice] - Kassa_1997_Cas.Lek.Cesk_136_124 |
| Author(s) : Kassa J , Vachek J |
| Ref : Casopis Lekaru Ceskych , 136 :124 , 1997 |
| Abstract : |
| PubMedSearch : Kassa_1997_Cas.Lek.Cesk_136_124 |
| PubMedID: 9221183 |
| Title : The efficacy of monopyridinium (2-PAAM, 2-PAEM) and bispyridinium (obidoxime, HI-6) oximes against mevinphos in mice - Kassa_1997_Pharmacol.Toxicol_81_144 |
| Author(s) : Kassa J , Bielavsky J |
| Ref : Pharmacol Toxicol , 81 :144 , 1997 |
| Abstract : |
| PubMedSearch : Kassa_1997_Pharmacol.Toxicol_81_144 |
| PubMedID: 9335072 |
| Title : Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning - Saxena_1997_Biochem.Pharmacol_54_269 |
| Author(s) : Saxena A , Maxwell DM , Quinn DM , Radic Z , Taylor P , Doctor BP |
| Ref : Biochemical Pharmacology , 54 :269 , 1997 |
| Abstract : |
| PubMedSearch : Saxena_1997_Biochem.Pharmacol_54_269 |
| PubMedID: 9271331 |
| Title : HI 6 dimethanesulfonate has better dissolution properties than HI 6 dichloride for application in dry\/wet autoinjectors - Thiermann_1996_Int.J.Pharm_137_167 |
| Author(s) : Thiermann H , Seidl S , Eyer P |
| Ref : Int J Pharm , 137 :167 , 1996 |
| Abstract : |
| PubMedSearch : Thiermann_1996_Int.J.Pharm_137_167 |
| PubMedID: |
| Title : [Comparison of the therapeutic effectiveness of selected cholinesterase reactivators with atropine in acute fosdrine poisoning in mice] - Kassa_1996_Ceska.Slov.Farm_45_31 |
| Author(s) : Kassa J , Bajgar J |
| Ref : Ceska a Slovenska Farmacie , 45 :31 , 1996 |
| Abstract : |
| PubMedSearch : Kassa_1996_Ceska.Slov.Farm_45_31 |
| PubMedID: 8620316 |
| Title : Oxime-induced reactivation of acetylcholinesterase inhibited by phosphoramidates - Jokanovic_1996_Toxicol.Lett_85_35 |
| Author(s) : Jokanovic M , Maksimovic M , Kilibarda V , Jovanovic D , Savic D |
| Ref : Toxicology Letters , 85 :35 , 1996 |
| Abstract : |
| PubMedSearch : Jokanovic_1996_Toxicol.Lett_85_35 |
| PubMedID: 8619258 |
| Title : Pharmacokinetics of atropine in dogs after i.m. injection with newly developed dry\/wet combination autoinjectors containing HI 6 or HLo 7 - Thiermann_1996_Arch.Toxicol_70_293 |
| Author(s) : Thiermann H , Radtke M , Spohrer U , Klimmek R , Eyer P |
| Ref : Archives of Toxicology , 70 :293 , 1996 |
| Abstract : |
| PubMedSearch : Thiermann_1996_Arch.Toxicol_70_293 |
| PubMedID: 8852700 |
| Title : Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes - Ashani_1995_J.Biol.Chem_270_6370 |
| Author(s) : Ashani Y , Radic Z , Tsigelny I , Vellom DC , Pickering NA , Quinn DM , Doctor BP , Taylor P |
| Ref : Journal of Biological Chemistry , 270 :6370 , 1995 |
| Abstract : |
| PubMedSearch : Ashani_1995_J.Biol.Chem_270_6370 |
| PubMedID: 7890775 |
| Title : [Comparison of the effect of selected cholinesterase reactivators combined with atropine on soman and fosdrin toxicity in mice] - Kassa_1995_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove.Suppl_38_63 |
| Author(s) : Kassa J |
| Ref : Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl , 38 :63 , 1995 |
| Abstract : |
| PubMedSearch : Kassa_1995_Sb.Ved.Pr.Lek.Fak.Karlovy.Univerzity.Hradci.Kralove.Suppl_38_63 |
| PubMedID: 9441373 |
| Title : Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin - Worek_1995_Toxicology_95_123 |
| Author(s) : Worek F , Kirchner T , Szinicz L |
| Ref : Toxicology , 95 :123 , 1995 |
| Abstract : |
| PubMedSearch : Worek_1995_Toxicology_95_123 |
| PubMedID: 7825179 |
| Title : Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats - Kassa_1995_Toxicology_101_167 |
| Author(s) : Kassa J |
| Ref : Toxicology , 101 :167 , 1995 |
| Abstract : |
| PubMedSearch : Kassa_1995_Toxicology_101_167 |
| PubMedID: 7676463 |
| Title : Non-reactivating effects of HI-6 on hippocampal neurotransmission - Melchers_1994_Arch.Toxicol_69_118 |
| Author(s) : Melchers BP , van der Laaken AL , Busker RW , Bruijnzeel PL , van Helden HP |
| Ref : Archives of Toxicology , 69 :118 , 1994 |
| Abstract : |
| PubMedSearch : Melchers_1994_Arch.Toxicol_69_118 |
| PubMedID: 7717860 |
| Title : Contribution of direct actions of the oxime HI-6 in reversing soman-induced muscle weakness in the rat diaphragm - Adler_1994_Eur.J.Pharmacol_270_9 |
| Author(s) : Adler M , Maxwell DM , Filbert MG , Deshpande SS |
| Ref : European Journal of Pharmacology , 270 :9 , 1994 |
| Abstract : |
| PubMedSearch : Adler_1994_Eur.J.Pharmacol_270_9 |
| PubMedID: 8157086 |
| Title : Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes - Caranto_1994_Biochem.Pharmacol_47_347 |
| Author(s) : Caranto GR , Waibel KH , Asher JM , Larrison RW , Brecht KM , Schutz MB , Raveh L , Ashani Y , Wolfe AD , Maxwell DM , Doctor BP |
| Ref : Biochemical Pharmacology , 47 :347 , 1994 |
| Abstract : |
| PubMedSearch : Caranto_1994_Biochem.Pharmacol_47_347 |
| PubMedID: 8304979 |
| Title : Effect of atropine, HLo 7 and HI 6 on respiratory and circulatory function in guinea-pigs poisoned by O-ethyl S-[2-(diisopropylamino) ethyl] methylphosponothioate (VX) - Worek_1994_Pharmacol.Toxicol_75_302 |
| Author(s) : Worek F , Kirchner T , Szinicz L |
| Ref : Pharmacol Toxicol , 75 :302 , 1994 |
| Abstract : |
| PubMedSearch : Worek_1994_Pharmacol.Toxicol_75_302 |
| PubMedID: 7870702 |
| Title : In vitro oxime-induced reactivation of various molecular forms of soman-inhibited acetylcholinesterase in striated muscle from rat, monkey and human - Clement_1994_Arch.Toxicol_68_648 |
| Author(s) : Clement JG , Erhardt N |
| Ref : Archives of Toxicology , 68 :648 , 1994 |
| Abstract : |
| PubMedSearch : Clement_1994_Arch.Toxicol_68_648 |
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| Title : Efficacy of antidotes against soman poisoning in female physostigmine-protected rats - Sket_1993_Pharmacol.Toxicol_72_25 |
| Author(s) : Sket D |
| Ref : Pharmacol Toxicol , 72 :25 , 1993 |
| Abstract : |
| PubMedSearch : Sket_1993_Pharmacol.Toxicol_72_25 |
| PubMedID: 93181392 |
| Title : Atropine and oxime treatment in lethal soman poisoning of anaesthetized guinea-pigs: HLo 7 dimethanesulfonate versus HI 6 dichloride - Worek_1993_Pharmacol.Toxicol_72_13 |
| Author(s) : Worek F , Szinicz L |
| Ref : Pharmacol Toxicol , 72 :13 , 1993 |
| Abstract : |
| PubMedSearch : Worek_1993_Pharmacol.Toxicol_72_13 |
| PubMedID: 8441735 |
| Title : Investigation of acute cardiovascular and respiratory toxicity of HLo 7 dimethanesulfonate and HI 6 dichloride in anaesthetized guinea-pigs - Worek_1993_Pharmacol.Toxicol_73_91 |
| Author(s) : Worek F , Szinicz L |
| Ref : Pharmacol Toxicol , 73 :91 , 1993 |
| Abstract : |
| PubMedSearch : Worek_1993_Pharmacol.Toxicol_73_91 |
| PubMedID: 8248012 |
| Title : Comparison of several oximes on reactivation of soman-inhibited blood, brain and tissue cholinesterase activity in rats - Shih_1993_Arch.Toxicol_67_637 |
| Author(s) : Shih TM |
| Ref : Archives of Toxicology , 67 :637 , 1993 |
| Abstract : |
| PubMedSearch : Shih_1993_Arch.Toxicol_67_637 |
| PubMedID: 8311691 |
| Title : The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats - Anderson_1992_Drug.Chem.Toxicol_15_285 |
| Author(s) : Anderson DR , Harris LW , Woodard CL , Lennox WJ |
| Ref : Drug & Chemical Toxicology , 15 :285 , 1992 |
| Abstract : |
| PubMedSearch : Anderson_1992_Drug.Chem.Toxicol_15_285 |
| PubMedID: 1459041 |
| Title : The synergism of atropine and the cholinesterase reactivator HI-6 in counteracting lethality by organophosphate intoxication in the rat - Ligtenstein_1991_Toxicol.Appl.Pharmacol_107_47 |
| Author(s) : Ligtenstein DA , Moes GW |
| Ref : Toxicology & Applied Pharmacology , 107 :47 , 1991 |
| Abstract : |
| PubMedSearch : Ligtenstein_1991_Toxicol.Appl.Pharmacol_107_47 |
| PubMedID: 1987659 |
| Title : Anticonvulsive and protective effects of diazepam and midazolam in rats poisoned by highly toxic organophosphorus compounds - Bokonjic_1991_Arh.Hig.Rada.Toksikol_42_359 |
| Author(s) : Bokonjic D , Rosic N |
| Ref : Arh Hig Rada Toksikol , 42 :359 , 1991 |
| Abstract : |
| PubMedSearch : Bokonjic_1991_Arh.Hig.Rada.Toksikol_42_359 |
| PubMedID: 1815490 |
| Title : A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning - Shih_1991_Toxicol.Lett_55_131 |
| Author(s) : Shih TM , Whalley CE , Valdes JJ |
| Ref : Toxicology Letters , 55 :131 , 1991 |
| Abstract : |
| PubMedSearch : Shih_1991_Toxicol.Lett_55_131 |
| PubMedID: 1998202 |
| Title : HI-6 and 2-PAM in sheep: pharmacokinetics and effects on muscle tissue following intramuscular injection - Moore_1991_Biopharm.Drug.Dispos_12_223 |
| Author(s) : Moore DH , Hayward IJ , Tucker FS , Lukey B |
| Ref : Biopharmaceutics & Drug Disposition , 12 :223 , 1991 |
| Abstract : |
| PubMedSearch : Moore_1991_Biopharm.Drug.Dispos_12_223 |
| PubMedID: 2059672 |
| Title : Disposition and metabolism of two acetylcholinesterase reactivators, pyrimidoxime and HI6, in rats submitted to organophosphate poisoning - Garrigue_1990_Xenobiotica_20_699 |
| Author(s) : Garrigue H , Maurizis JC , Nicolas C , Madelmont JC , Godeneche D , Hulot T , Morge X , Demerseman P , Sentenac-Roumanou H , Veyre A |
| Ref : Xenobiotica , 20 :699 , 1990 |
| Abstract : |
| PubMedSearch : Garrigue_1990_Xenobiotica_20_699 |
| PubMedID: 2146816 |
| Title : [The effect of the oxime HI-6 on miosis induced by topical administration of sarin and VX in the rabbit eye] - Macic_1990_Vojnosanit.Pregl_47_399 |
| Author(s) : Macic I , Vojvodic V , Knezevic D , Maksimovic M |
| Ref : Vojnosanit Pregl , 47 :399 , 1990 |
| Abstract : |
| PubMedSearch : Macic_1990_Vojnosanit.Pregl_47_399 |
| PubMedID: 2075700 |
| Title : A new H-oxime restores rat diaphragm contractility after esterase inhibition in vitro - Alberts_1990_Eur.J.Pharmacol_184_191 |
| Author(s) : Alberts P |
| Ref : European Journal of Pharmacology , 184 :191 , 1990 |
| Abstract : |
| PubMedSearch : Alberts_1990_Eur.J.Pharmacol_184_191 |
| PubMedID: 2209712 |
| Title : Side effects of therapeutic drugs against organophosphate poisoning - Wolthuis_1989_Neurotoxicol.Teratol_11_221 |
| Author(s) : Wolthuis OL , Philippens IH , Vanwersch RA |
| Ref : Neurotoxicology & Teratology , 11 :221 , 1989 |
| Abstract : |
| PubMedSearch : Wolthuis_1989_Neurotoxicol.Teratol_11_221 |
| PubMedID: 2666846 |
| Title : The relationship between oxime-induced reactivation of carbamylated acetylcholinesterase and antidotal efficacy against carbamate intoxication - Harris_1989_Toxicol.Appl.Pharmacol_98_128 |
| Author(s) : Harris LW , Talbot BG , Lennox WJ , Anderson DR |
| Ref : Toxicology & Applied Pharmacology , 98 :128 , 1989 |
| Abstract : |
| PubMedSearch : Harris_1989_Toxicol.Appl.Pharmacol_98_128 |
| PubMedID: 2494778 |
| Title : Study on the stability of the oxime HI 6 in aqueous solution - Eyer_1988_Arch.Toxicol_62_224 |
| Author(s) : Eyer P , Hagedorn I , Ladstetter B |
| Ref : Archives of Toxicology , 62 :224 , 1988 |
| Abstract : |
| PubMedSearch : Eyer_1988_Arch.Toxicol_62_224 |
| PubMedID: 3196158 |
| Title : Identification of two metabolites of the cholinesterase reactivator HI-6 isolated from rat urine - Ligtenstein_1987_J.Pharm.Pharmacol_39_17 |
| Author(s) : Ligtenstein DA , Wils ER , Kossen SP , Hulst AG |
| Ref : J Pharm Pharmacol , 39 :17 , 1987 |
| Abstract : |
| PubMedSearch : Ligtenstein_1987_J.Pharm.Pharmacol_39_17 |
| PubMedID: 2880978 |
| Title : [Comparative reactivation efficacy of the oximes HI-6 and HGG-12 in the central nervous system and blood of rats poisoned with nerve gases used in warfare] - |
| Author(s) : Pantelic D |
| Ref : Godisnjak Vojnomedicinske Akademije , 28 :35 , 1986 |
| PubMedID: 3482058 |
| Title : Studies on the decomposition of the oxime HI 6 in aqueous solution - Eyer_1986_Arch.Toxicol_59_266 |
| Author(s) : Eyer P , Hell W , Kawan A , Klehr H |
| Ref : Archives of Toxicology , 59 :266 , 1986 |
| Abstract : |
| PubMedSearch : Eyer_1986_Arch.Toxicol_59_266 |
| PubMedID: 3827594 |
| Title : Pharmacokinetics and pharmacodynamics of the oxime HI6 in dogs - Klimmek_1986_Arch.Toxicol_59_272 |
| Author(s) : Klimmek R , Eyer P |
| Ref : Archives of Toxicology , 59 :272 , 1986 |
| Abstract : |
| PubMedSearch : Klimmek_1986_Arch.Toxicol_59_272 |
| PubMedID: 3827595 |
| Title : Stability studies of bis(pyridiniumaldoxime) reactivators of organophosphate-inhibited acetylcholinesterase - Lin_1986_J.Pharmaceutical.Sci_75_797 |
| Author(s) : Lin AJ , Klayman DL |
| Ref : Journal of Pharmaceutical Sciences , 75 :797 , 1986 |
| Abstract : |
| PubMedSearch : Lin_1986_J.Pharmaceutical.Sci_75_797 |
| PubMedID: 3772753 |
| Title : Reactivation of ethyl methylphosphonylated eel acetylcholinesterase in vitro by 2PAM, H16, and a series of nonquaternary alpha-ketothiohydroximates - |
| Author(s) : Kenley RA , Bedford CD , Howd RA , Jackson SE |
| Ref : Biochemical Pharmacology , 34 :3606 , 1985 |
| PubMedID: 4052103 |
| Title : Effects of HI-6 and pralidoxime on neuronal RNA in thalamic cholinergic sites - Martin_1985_J.Neurol.Sci_71_1 |
| Author(s) : Martin LJ , Doebler JA , Anthony A |
| Ref : Journal of the Neurological Sciences , 71 :1 , 1985 |
| Abstract : |
| PubMedSearch : Martin_1985_J.Neurol.Sci_71_1 |
| PubMedID: 2418157 |
| Title : Stability study of HI-6 dichloride in various anticholinergic formulations - |
| Author(s) : Brown ND , Gray RR , Stermer-Cox MG , Doctor BP , Hagedorn I |
| Ref : Journal of Chromatography , 315 :389 , 1984 |
| PubMedID: 6526905 |
| Title : PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning - Boskovic_1984_Fundam.Appl.Toxicol_4_S106 |
| Author(s) : Boskovic B , Kovacevic V , Jovanovic D |
| Ref : Fundamental & Applied Toxicology , 4 :S106 , 1984 |
| Abstract : |
| PubMedSearch : Boskovic_1984_Fundam.Appl.Toxicol_4_S106 |
| PubMedID: 6724203 |
| Title : [Trial of cholinesterase reactivators as proserine antagonists]. [Russian] - Prozorovskii_1983_Biull.Eksp.Biol.Med_96_66 |
| Author(s) : Prozorovskii VB , Khramova EA , Ardab'eva TV |
| Ref : Biulleten Eksperimentalnoi Biologii i Meditsiny , 96 :66 , 1983 |
| Abstract : |
| PubMedSearch : Prozorovskii_1983_Biull.Eksp.Biol.Med_96_66 |
| PubMedID: 6354300 |
| Title : Reactivation of acetylcholinesterase inhibited by 1,2,2'-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes - |
| Author(s) : De Jong LP , Wolring GZ |
| Ref : Biochemical Pharmacology , 29 :2379 , 1980 |
| PubMedID: 7426043 |
| Title : [Reactivation of phosphorylated acetylcholine esterase with oximes: contribution to the study of the reaction course] - |
| Author(s) : Hagedorn I , Gundel WH , Schoene K |
| Ref : Arzneimittelforschung , 19 :603 , 1969 |
| PubMedID: 5819160 |