| Title : Two Enzyme Cooperatively Catalyzed Tandem Polymerization for the Synthesis of Polyester Containing Chiral (R)- or (S)-Ibuprofen Pendants - Qian_2014_Macromol.Rapid.Commun_35_1788 |
| Author(s) : Qian X , Wang J , Li Y , Lin X , Wu Q |
| Ref : Macromol Rapid Commun , 35 :1788 , 2014 |
| Abstract : An interesting cooperation between Candida antarctica Lipase B (CAL-B) and alkaline protease from Bacillus subtilis (BSP) in the copolymerization of bulky ibuprofen-containing hydroxyacid methyl ester (HAEP) and sigma-caprolactone (sigma-CL) is observed. This cooperation improved the Mn of the polymers from 3130 (CAL-B) to 9200 g mol(-1) (CAL-B/BSP). Experimental results clearly indicate that CAL-B mainly catalyzes the ring-opening polymerization (ROP) of sigma-CL under the initiation of HAEP to form the homopolymer of sigma-CL, while BSP catalyzes the subsequent polycondensation of the ROP product to yield the copolymer with increased molecular weight. Furthermore, using suitable chemo-enzymatic methods, valuable polyesters with chiral (R)- or (S)-ibuprofen pendants can be tailor-made. |
| ESTHER : Qian_2014_Macromol.Rapid.Commun_35_1788 |
| PubMedSearch : Qian_2014_Macromol.Rapid.Commun_35_1788 |
| PubMedID: 25200738 |
Qian X, Wang J, Li Y, Lin X, Wu Q (2014)
Two Enzyme Cooperatively Catalyzed Tandem Polymerization for the Synthesis of Polyester Containing Chiral (R)- or (S)-Ibuprofen Pendants
Macromol Rapid Commun
35 :1788
Qian X, Wang J, Li Y, Lin X, Wu Q (2014)
Macromol Rapid Commun
35 :1788