| Title : Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide - Racys_2010_Bioorg.Med.Chem_18_4775 |
| Author(s) : Racys DT , Rea D , Fulop V , Wills M |
| Ref : Bioorganic & Medicinal Chemistry , 18 :4775 , 2010 |
|
Abstract :
A new inhibitor, containing a linked proline-piperidine structure, for the enzyme prolyl oligopeptidase (POP) has been synthesised and demonstrated to bind covalently with the enzyme at the active site. This provides evidence that covalent inhibitors of POP do not have to be limited to structures containing five-membered N-containing heterocyclic rings. |
| PubMedSearch : Racys_2010_Bioorg.Med.Chem_18_4775 |
| PubMedID: 20627594 |
| Gene_locus related to this paper: pig-ppce |
| Inhibitor | Z-Pro-Prolinal-derived |
| Gene_locus | pig-ppce |
| Structure | 2XDW |
Racys DT, Rea D, Fulop V, Wills M (2010)
Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide
Bioorganic & Medicinal Chemistry
18 :4775
Racys DT, Rea D, Fulop V, Wills M (2010)
Bioorganic & Medicinal Chemistry
18 :4775