Rea D

References (13)

Title : Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling - Rea_2017_Eur.J.Med.Chem_139_482
Author(s) : Rea D , Van Elzen R , De Winter H , Van Goethem S , Landuyt B , Luyten W , Schoofs L , Van der Veken P , Augustyns K , De Meester I , Fulop V , Lambeir AM
Ref : Eur Journal of Medicinal Chemistry , 139 :482 , 2017
PubMedID: 28826083
Gene_locus related to this paper: porgi-DPP

Title : Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes - Canning_2013_PLoS.One_8_e79349
Author(s) : Canning P , Rea D , Morty RE , Fulop V
Ref : PLoS ONE , 8 :e79349 , 2013
PubMedID: 24265767
Gene_locus related to this paper: trybr-PEPTB

Title : P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy - Van der Veken_2012_J.Med.Chem_55_9856
Author(s) : Van der Veken P , Fulop V , Rea D , Gerard M , Van Elzen R , Joossens J , Cheng JD , Baekelandt V , De Meester I , Lambeir AM , Augustyns K
Ref : Journal of Medicinal Chemistry , 55 :9856 , 2012
PubMedID: 23121075
Gene_locus related to this paper: pig-ppce

Title : The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity - Szeltner_2012_Biochim.Biophys.Acta_1834_98
Author(s) : Szeltner Z , Juhasz T , Szamosi I , Rea D , Fulop V , Modos K , Juliano L , Polgar L
Ref : Biochimica & Biophysica Acta , 1834 :98 , 2012
PubMedID: 22940581
Gene_locus related to this paper: pig-ppce

Title : Prolyl oligopeptidase structure and dynamics - Rea_2011_CNS.Neurol.Disord.Drug.Targets_10_306
Author(s) : Rea D , Fulop V
Ref : CNS Neurol Disord Drug Targets , 10 :306 , 2011
PubMedID: 21222626

Title : Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide - Racys_2010_Bioorg.Med.Chem_18_4775
Author(s) : Racys DT , Rea D , Fulop V , Wills M
Ref : Bioorganic & Medicinal Chemistry , 18 :4775 , 2010
PubMedID: 20627594
Gene_locus related to this paper: pig-ppce

Title : Structure-function properties of prolyl oligopeptidase family enzymes - Rea_2006_Cell.Biochem.Biophys_44_349
Author(s) : Rea D , Fulop V
Ref : Cell Biochem Biophys , 44 :349 , 2006
PubMedID: 16679522

Title : Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding - Szeltner_2004_J.Mol.Biol_340_627
Author(s) : Szeltner Z , Rea D , Juhasz T , Renner V , Fulop V , Polgar L
Ref : Journal of Molecular Biology , 340 :627 , 2004
PubMedID: 15210359
Gene_locus related to this paper: pig-q6q2c2

Title : Expression, purification and preliminary crystallographic analysis of dipeptidyl peptidase IV from Porphyromonas gingivalis - Rea_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1871
Author(s) : Rea D , Lambeir AM , Kumagai Y , De Meester I , Scharpe S , Fulop V
Ref : Acta Crystallographica D Biol Crystallogr , 60 :1871 , 2004
PubMedID: 15388936
Gene_locus related to this paper: porgi-DPP

Title : Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis. Comparison with the human enzyme -
Author(s) : Lambeir AM , Rea D , Fulop V , Kumagai Y , Augustyns K , De Meester I , Haemers A , Scharpe S
Ref : Advances in Experimental Medicine & Biology , 524 :29 , 2003
PubMedID: 12675220

Title : Electrostatic environment at the active site of prolyl oligopeptidase is highly influential during substrate binding - Szeltner_2003_J.Biol.Chem_278_48786
Author(s) : Szeltner Z , Rea D , Renner V , Juliano L , Fulop V , Polgar L
Ref : Journal of Biological Chemistry , 278 :48786 , 2003
PubMedID: 14514675
Gene_locus related to this paper: pig-ppce

Title : Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site - Szeltner_2002_J.Biol.Chem_277_42613
Author(s) : Szeltner Z , Rea D , Renner V , Fulop V , Polgar L
Ref : Journal of Biological Chemistry , 277 :42613 , 2002
PubMedID: 12202494
Gene_locus related to this paper: pig-ppce

Title : Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase - Szeltner_2002_J.Biol.Chem_277_44597
Author(s) : Szeltner Z , Rea D , Juhasz T , Renner V , Mucsi Z , Orosz G , Fulop V , Polgar L
Ref : Journal of Biological Chemistry , 277 :44597 , 2002
PubMedID: 12228249
Gene_locus related to this paper: pig-ppce