Rausch_1985_Eur.J.Pharmacol_109_91

Reference

Title : Physostigmine effects on serotonin uptake in human blood platelets - Rausch_1985_Eur.J.Pharmacol_109_91
Author(s) : Rausch JL , Janowsky DS , Risch SC , Huey LY
Ref : European Journal of Pharmacology , 109 :91 , 1985
Abstract :

Platelet serotonin (5HT) uptake was measured in 18 subjects administered physostigmine salicylate in a double-blind, placebo crossover design. In comparison to placebo, the drug caused a significant transient depression in mood, as measured by self- and observer-rated depression scores. In addition, physostigmine significantly increased platelet counts while independently decreasing the maximum velocity (Vmax) of platelet serotonin uptake. Physostigmine administration did not significantly affect the affinity constant (Km) for platelet serotonin uptake. The data are interpreted as being consistent with the postulate that platelet serotonin uptake may be decreased in depressed patients via cholinergic mechanisms.

PubMedSearch : Rausch_1985_Eur.J.Pharmacol_109_91
PubMedID: 3996470

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Citations formats

Rausch JL, Janowsky DS, Risch SC, Huey LY (1985)
Physostigmine effects on serotonin uptake in human blood platelets
European Journal of Pharmacology 109 :91

Rausch JL, Janowsky DS, Risch SC, Huey LY (1985)
European Journal of Pharmacology 109 :91