| Title : In vitro neurotoxic esterase assay using leptophos oxon analogs as inhibitors - Reinders_1983_Toxicol.Lett_17_107 |
| Author(s) : Reinders JH , Hansen LG , Metcalf RL |
| Ref : Toxicol Lett , 17 :107 , 1983 |
|
Abstract :
In comparing neurotoxic esterase (NTE) inhibition properties of a series of phenylphosphonates, it was discovered that certain compounds including leptophos inhibited mipafox-insensitive phenylvalerate hydrolases. This leads to erroneous values for NTE inhibition which can be corrected by a differential assay: the total amount of mipafox-insensitive activity is determined with O-(2,6-dichlorophenyl)O-methyl phenylphosphonate and subtracted from the apparent NTE determined with the test compound before calculating pI50's. |
| PubMedSearch : Reinders_1983_Toxicol.Lett_17_107 |
| PubMedID: 6623496 |
Reinders JH, Hansen LG, Metcalf RL (1983)
In vitro neurotoxic esterase assay using leptophos oxon analogs as inhibitors
Toxicol Lett
17 :107
Reinders JH, Hansen LG, Metcalf RL (1983)
Toxicol Lett
17 :107