Robertson_1988_J.Toxicol.Environ.Health_23_283

Reference

Title : Time course of electrophysiologic effects induced by di-n-butyl-2,2-dichlorovinyl phosphate (DBCV) in the adult hen - Robertson_1988_J.Toxicol.Environ.Health_23_283
Author(s) : Robertson DG , Mattson AM , Bestervelt LL , Richardson RJ , Anderson RJ
Ref : J Toxicol Environ Health , 23 :283 , 1988
Abstract :

Previous work in our laboratory indicated that di-n-butyl-2,2-dichlorovinyl phosphate (DBCV) produced electrophysiologic changes in hen peripheral nerve that coincided with the development of histopathologic changes and neurologic signs of peripheral neuropathy. The purpose of the present study was to follow the time course for the development of the electrophysiologic changes and to determine whether pretreatment with the phosphinate analog of DBCV (DBCV-P), a nonageable organophosphorus compound, prevented these effects. Although significant electrophysiologic deficits occurred in the tibial and sciatic nerve 24 h after DBCV treatment, the most marked changes coincided with the onset of clinical signs of organophosphorus-induced delayed neuropathy (14-21 d). The sciatic and tibial nerves were equally susceptible to DBCV in producing deficits characterized by changes in the relative refractory period and an increased strength-duration threshold. Pretreatment with DBCV-P prevented the clinical signs and also attenuated the electrophysiologic deficits induced by DBCV treatment. These data suggest that electrophysiologic deficits occur before clinical signs of organophosphorus-induced delayed neuropathy (OPIDN) and may be indicative of a link between neurotoxic esterase (NTE) inhibition and onset of overt clinical toxicity.

PubMedSearch : Robertson_1988_J.Toxicol.Environ.Health_23_283
PubMedID: 3351976

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Citations formats

Robertson DG, Mattson AM, Bestervelt LL, Richardson RJ, Anderson RJ (1988)
Time course of electrophysiologic effects induced by di-n-butyl-2,2-dichlorovinyl phosphate (DBCV) in the adult hen
J Toxicol Environ Health 23 :283

Robertson DG, Mattson AM, Bestervelt LL, Richardson RJ, Anderson RJ (1988)
J Toxicol Environ Health 23 :283